A High Serum Iron Level Causes Mouse Retinal Iron Accumulation Despite an Intact Blood-Retinal Barrier

Autor: Yafeng Li, Guanfang Su, Milan Theurl, Joshua L. Dunaief, Ying Song, L. Zhao, Delu Song, Chenguang Wang, Alyssa Cwanger

Publikováno v: The American Journal of Pathology. 184:2862-2867

The retina can be shielded by the blood-retinal barrier. Because photoreceptors are damaged by excess iron, it is important to understand whether the blood-retinal barrier protects against high serum iron levels. Bone morphogenic protein 6 (Bmp6) kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110bf4b31b6e26bbd64152f41f3692b0
https://doi.org/10.1016/j.ajpath.2014.07.008

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

Autor: Michael K. Lee, Hyder A. Jinnah, Predrag Krajacic, Jared Iacovelli, Chenguang Wang, James R. Connor, Jolanta Wodzinska, Alyssa Cwanger Weissberger, Michael Spino, L. Zhao, Benoit I. Giasson, John T. Connelly, Ying Song, Z. Leah Harris, Majda Hadziahmetovic, Xueying Xu, Joshua L. Dunaief, Natalie Wolkow

Publikováno v: Journal of neurochemistry. 135(5)

Brain iron accumulates in several neurodegenerative diseases and can cause oxidative damage, but mechanisms of brain iron homeostasis are incompletely understood. Patients with mutations in the cellular iron-exporting ferroxidase ceruloplasmin (Cp) h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64d76b4e358e738b8685407bee32369
https://pubmed.ncbi.nlm.nih.gov/26303407

Contributors

Autor: Winsome Abbott-Johnson, Niyazi Acar, Vaishali Agte, Daniel Agudelo, Maria Antonietta Altea, R.A. Armstrong, Tin Aung, Bahri Aydın, Fereshteh Bahmani, D. Balmer, S. Zahra Bathaie, Lynne Bell, Tos T.J.M. Berendschot, Paul S. Bernstein, Brian M. Besch, Philippe Bourassa, R.B. Bozard, Lionel Bretillon, Alain M. Bron, Benjamin Buaud, Gabriëlle H.S. Buitendijk, Laurie T. Butler, Aldo Caporossi, Stefano Caragiuli, Chloé Cartier, Cristina Cartiglia, Chi-Ming Chan, Min-Lee Chang, Bashira A. Charles, Emily Y. Chew, Ching-Yu Cheng, Chung-Jung Chiu, Deepika Chopra, Patricia Coelho de Velasco, David Coman, Nicole Combe, Dolores Corella, M. Cossenza, Simonetta Costa, Catherine P. Creuzot-Garcher, Maria Cristina de Oliveira Izar, R.P. Cubbidge, Alyssa Cwanger, Cécile Delcourt, Marie-Noëlle Delyfer, I.C.L. Domith, David Dunaief, Joshua L. Dunaief, Rajan Elanchezhian, Andrew W. Eller, T.G. Encarnação, Mesut Erdurmuş, Evangelina Espósito, Asghar Farajzadeh, David T. Field, Silvia C. Finnemann, Steven J. Fliesler, Nicolas Froger, P.S. Ganapathy, V. Ganapathy, Jose J. Garcia-Medina, Pitchairaj Geraldine, Carmen Giannantonio, C.R. Gibson, Snehal Gite, N. Goldenberg-Cohen, Glen Gole, Ian R. Gorovoy, Julia A. Haller, Lisa Hark, Rijo Hayashi, Hui He, Tatiana Helfenstein, Francisco Antonio Helfenstein Fonseca, Ken-ichi Hosoya, Yi-Ling Huang, Chi-Feng Hung, M. Ibberson, Hiroto Izumi, Alberto Izzotti, Riikka L. Järvinen, Hua Ji, Yao Jin, Corinne Joffre, Choun-Ki Joo, Sang Hoon Jung, Heikki P. Kallio, Paul Kerlin, Eun Chul Kim, Jin Sook Kim, Amar U. Kishan, Caroline C.W. Klaver, Kimitoshi Kohno, Jean-François Korobelnik, Yoshiyuki Kubo, Petra S. Larmo, Ryszard Lauterbach, Ling-Jun Li, Dingbo Lin, M.I. Lopez-Galvez, Yi Lu, Zhi-Quan Lu, F. Manco Lavado, Claudio Marcocci, Shilpa Mathew, Cosimo Mazzotta, Francesca Menconi, Naoya Miyamoto, Bobeck S. Modjtahedi, Lawrence S. Morse, Sarah W. Mount, Arumugam R. Muralidharan, Benjamin P. Nicholson, R. Paes-de-Carvalho, J.C. Pastor, Dorota Pawlik, John F. Payne, Daniel Petrovič, Serge Picaud, Maria D. Pinazo-Duran, Adela Mariana Pintea, Jogchum Plat, C.C. Portugal, Ananda S. Prasad, Victor R. Preedy, Jiang Qin, R. Roduit, Costantino Romagnoli, Marie-Bénédicte Rougier, Dumitriţa Olivia Rugină, Charumathi Sabanayagam, Sergio Claudio Saccà, José-Alain Sahel, Dave Saint-Amour, Pedro Sanz-Solana, Seang Mei Saw, D.F. Schorderet, Claudio Alberto Serfaty, Horacio M. Serra, Saumil Sethna, Jay Siak, Hüseyin Simavlı, S.B. Smith, S.M. Smith, R. Socodato, Marco Spinazzi, K. Srinivasan, Philip Storey, María Fernanda Suárez, H.A. Tajmir-Riahi, Gavin S. Tan, Vin Tangpricha, Akihiko Tawara, P. Archana Teresa, Philip A. Thomas, Mehmet Tosun, Julio A. Urrets-Zavalía, Preejith P. Vachali, Carole Vaysse, Sabrina Viau, Claire M. Williams, Tien Y. Wong, Chen Xi, Ramazan Yağcı, Jia Yan, Baoru Yang, Ji Yong, Vicente Zanon-Moreno, Xiangjia Zhu, S.R. Zwart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72795346c3223738c3063ae702c968e8
https://doi.org/10.1016/b978-0-12-401717-7.01002-9

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The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms

Autor: Majda Hadziahmetovic, Ying Song, Steven Grieco, Michael Spino, Yafeng Li, Gui-Shuang Ying, John Connelly, Joshua L. Dunaief, Jared Iacovelli, Miroslav Pajic, Alyssa Cwanger, Delu Song, Sally Chu

PURPOSE To investigate the effect of the iron chelator deferiprone (DFP) on sodium iodate (NaIO3)-induced retinal degeneration and on the hereditary retinal degeneration caused by the rd6 mutation. METHODS Retinas from NaIO3-treated C57BL/6J mice, wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f313f4023edc5523be10beafc728e6
https://europepmc.org/articles/PMC3763881/