The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

Autor: Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Céline Desbourdes, Cécile Cottet-Rousselle, Isabelle Hininger-Favier, Stéphane Attia, Béatrice Nawrocki-Raby, Joël Raingeaud, Christelle Machon, Jérôme Guitton, Morgane Le Gall, Guilhem Clary, Cedric Broussard, Philippe Chafey, Patrice Thérond, David Bernard, Eric Fontaine, Malgorzata Tokarska-Schlattner, Patricia Steeg, Ivan Bièche, Uwe Schlattner, Mathieu Boissan

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-29 (2021)

Abstract Background Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. Results We constructed loss-of-function mutants of NDPK-D, l

Externí odkaz: https://doaj.org/article/64c3e3bcb5024675ac11f551606b20d8

Relaxing conditional independence in an endogenous binary response model

Autor: Alyssa Carlson

Publikováno v: Journal of Econometrics. 232:490-500

For binary response models, the literature primarily addresses endogeneity by a control function approach assuming conditional independence (CF-CI). However, as the literature also notes, CF-CI implies conditions like homoskedasticity (of the latent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d6f83fc4eda679a68995880ef40dba4
https://doi.org/10.1016/j.jeconom.2021.09.015

The molecular and cellular basis of copper dysregulation and its relationship with human pathologies

Autor: Teresita Padilla-Benavides, Lobna Elkhadragy, Monserrat Olea-Flores, Kyle M. Schachtschneider, Alyssa Carlson, May T Maung, Napoleón Navarro-Tito

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(9)

Copper (Cu) is an essential micronutrient required for the activity of redox-active enzymes involved in critical metabolic reactions, signaling pathways, and biological functions. Transporters and chaperones control Cu ion levels and bioavailability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fb172aeccdcff301665b1ea97786b8
https://pubmed.ncbi.nlm.nih.gov/34390520

Abstract ND01: KSQ-4279: A first-in-class USP1 inhibitor for the treatment of cancers with homologous recombination deficiencies

Autor: Louise Cadzow, Erica Tobin, Pamela Sullivan, Sol Shenker, Sumeet Nayak, Janid Ali, Hugh Gannon, Anne Dodson, Paula Grasberger, Alyssa Carlson, Michael McGuire, Jehrod Brenneman, Hanlan Liu, Andrew Olaharski, Kerstin Sinkevicius, Jeff Hixon, Elsa Krall, Mike Schlabach, Matt Goulet, Jeremy Wilt, Patricia Harris, Frank Stegmeier, Andrew Wylie

Publikováno v: Cancer Research. 82:ND01-ND01

Tumors with BRCA1/2 mutations and other homologous repair deficiencies (HRD) are vulnerable to agents that target the remaining DNA repair pathways, including platinum-containing chemotherapy agents and molecules targeting poly (ADP-ribose) polymeras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9539d68445d92dc285a006c95dfa078
https://doi.org/10.1158/1538-7445.am2022-nd01

The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor

Autor: David Bernard, Malgorzata Tokarska-Schlattner, Anda Huna, Patrice Thérond, Isabelle Hininger-Favier, Sophie Vacher, Patricia S. Steeg, Céline Desbourdes, Guilhem Clary, Philippe Chafey, Morgane Le Gall, Imran Khan, Jérôme Guitton, Olivier De Wever, Christelle Machon, Alyssa Carlson, Ivan Bièche, Teresita Padilla-Benavides, Cécile Cottet-Rousselle, Uwe Schlattner, Stéphane Attia, Béatrice Nawrocki-Raby, Cédric Broussard, Frédéric Lamarche, Mathieu Boissan, Joël Raingeaud, Marie-Lise Lacombe, Claire Calmel, Eric Fontaine

Publikováno v: BMC BIOLOGY
BMC Biology
BMC Biology, BioMed Central, 2021, 19 (1), ⟨10.1186/s12915-021-01155-5⟩
BMC Biology, 2021, 19 (1), ⟨10.1186/s12915-021-01155-5⟩
BMC Biology, Vol 19, Iss 1, Pp 1-29 (2021)

Background Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. Results We constructed loss-of-function mutants of NDPK-D, lacking ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbd007d0c6d8a5153e3d323369cab8a
https://hdl.handle.net/1854/LU-8738468