Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alyssa B. O'Neill"'
Autor:
Rodger F. Henry, Steven A. Buckner, Michael E. Brune, Tracy L. Carr, Sweta P. Katwala, Masaki Nakane, Thomas R. Miller, Arthur A. Hancock, Jorge D. Brioni, Anthony V. Daza, Michael Meyer, John C Cain, William A. Carroll, Robert J. Altenbach, Albert Khilevich, Lynne M. Ireland, Fan Yang, Mark W. Holladay, Meena V. Patel, Rohde Jeffrey J, William H. Bunnelle, Chae H Kang, Timothy A. Esbenshade, Donna M. Gauvin, Teodozyj Kolasa, James P. Sullivan, Karin R. Tietje, Jane Kuk, Pramila Bhatia, Alyssa B. O'Neill, Searle Xenia B, Ivan Milicic, Erol K. Bayburt
Publikováno v:
Journal of Medicinal Chemistry. 47:3220-3235
Structure-activity studies were performed on the alpha(1A)-adrenoceptor (AR) selective agonist N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide (4). Compounds were evaluated for binding activity at the alpha(1A), alpha(1b)
Publikováno v:
European Journal of Pharmacology. 458:183-189
The aim of present study was to characterize the in vitro and in vivo pharmacological effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), a soluble guanylate cyclase activator, on corpus cavernosal smooth muscle and penile erectile act
Autor:
Alyssa B. O'Neill, Donna M. Gauvin, James P. Sullivan, Arthur A. Hancock, Jorge D. Brioni, Michael E. Brune, Robert J. Altenbach, Sweta P. Katwala
Publikováno v:
Journal of Urology. 166:1555-1559
Purpose: We describe and compare the usefulness of 3 minimally invasive dog urethral function models to demonstrate the efficacy potential of α1 agonists for stress urinary incontinence. From this overall composite dataset the efficacy profiles of t
Publikováno v:
Neurobiology of Learning and Memory. 69:46-64
Injections of quinolinic acid (60, 180, and 600 nmol) in the dorsal hippocampus induced significant neurotoxicity that was evident 1 day after the injection. By day 3, pyramidal as well as granular cells were affected even at the lowest dose of quino
Autor:
Mark S. Brodie, David J.B. Kim, Jorge D. Brioni, Stephen P. Arneric, Michael W. Decker, Alyssa B. O'Neill
Publikováno v:
Drug Development Research. 40:259-266
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy) pyridine dihydrochloride] is a novel cholinergic channel modulator (ChCM) with cognitive-enhancing and neuroprotective activities. Experiments were conducted to determine the discriminative stimulus pro
Autor:
Nan-Horng Lin, Alyssa B. O'Neill, David J. Anderson, David S. Garvey, Richard L. Elliott, Michael W. Decker, Mark W. Holladay, James P. Sullivan, Michael J. Buckley, Karen L. Gunther, Stephen P. Arneric, David E. Gunn, Keith B. Ryther, Jeffrey E. Campbell, Hana Kopecka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2283-2288
A series of 2-(aryloxymethyl) azetidine and pyrrolidine nAChR ligands in which the 3-pyridyl moiety of a previously described series 1 was replaced by a substituted phenyl group was explored. Aromatic substitution afforded analogues with K i values r
Autor:
Chun Wel Lin, Thomas R. Miller, Alex M. Nadzan, Mark W. Holladay, James F. Kerwin, Alyssa B. O'Neill, Michael J. Bennett, Hao Bai, Michael Stashko, Jorge D. Brioni, Jeffrey W. Ralston
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:3057-3062
The development of a novel series of carbamoylamino acid benzoylpiperidides as CCK B ligands is described. Selected members of the series antagonized CCK 8 -induced calcium mobilization and showed efficacy in the mouse elevated-plus maze, a measure o
Publikováno v:
Brain Research. 643:1-9
Rats were trained to discriminate 1.9 μmol/kg (−)-nicotine (0.3 mg/kg) from saline in a standard two-bar operant conditioning paradigm with food reinforcement. The effect of neuronal nicotinic acetylcholine receptor (nAChR) agonists and antagonist
Autor:
Alyssa B. O'Neill, Jorge D. Brioni
Publikováno v:
Drug Development Research. 31:38-44
The effect of the benzodiazepine-receptor antagonist flumazenil on the facilitatory effect of (−)-nicotine on memory in septal-lesioned rats in a spatial task and in the inhibitory avoidance test in mice was investigated. In the two-platform spatia
Autor:
Masaki Nakane, John C. Cain, Steven A. Buckner, Anthony V. Daza, Michael E. Brune, Robert J. Altenbach, Alyssa B. O'Neill, James P. Sullivan, Ivan Milicic, Michael Meyer, Michael Williams, Albert Khilevich, Mark W. Holladay, Donna M. Gauvin, Jorge D. Brioni
Publikováno v:
Journal of Medicinal Chemistry. 45:4395-4397
N-[3-(1H-Imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1) is a novel α1 agent having the unique profile of α1A (rabbit urethra, EC50 = 0.60 μM) agonism with α1B (rat spleen, pA2 = 5.4) and α1D (rat aorta, pA2 = 6.2) antagonism. An in vi