Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alyssa B. Long"'
Autor:
Madison F Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Annabel Lee, Alyssa B Long, Mattie J Casey, Abhishek Poddar, Isaac B Nelson, Corvin D Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M Kwan, Stefan Schulz, Rodney A Stewart, John J G Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R Myers
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002685 (2024)
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and physically
Externí odkaz:
https://doaj.org/article/dd4df563bde8484e9cf388d6a8c3f333
Autor:
Madison F. Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Alyssa B. Long, Mattie J. Casey, Abhishek Poddar, Isaac B. Nelson, Corvin D. Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M. Kwan, Stefan Schulz, Rodney A. Stewart, John J. G. Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R. Myers
Publikováno v:
bioRxiv
During Hedgehog (Hh) signal transduction in development, homeostasis, and cancer, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by directly binding the PKA catalytic subunit (PKA-C) and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f849ab21c1dc2a9f085f18f5c84fc5
https://doi.org/10.1101/2023.05.10.540226
https://doi.org/10.1101/2023.05.10.540226
Publikováno v:
bioRxiv
ARL13B is a small GTPase enriched in cilia. Deletion ofArl13bin mouse kidney results in renal cysts and an associated absence of primary cilia. Similarly, ablation of cilia leads to kidney cysts. To investigate whether ARL13B functions from within ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405e38498842afdc7147111a36708dbe
https://europepmc.org/articles/PMC9934666/
https://europepmc.org/articles/PMC9934666/
Publikováno v:
Genetics
Patients with the ciliopathy Joubert syndrome present with physical anomalies, intellectual disability, and a hindbrain malformation described as the “molar tooth sign” due to its appearance on an MRI. This radiological abnormality results from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccff04ceb7a578f3f8e4469cf948187
https://doi.org/10.1093/genetics/iyab084
https://doi.org/10.1093/genetics/iyab084
Publikováno v:
Development
Sonic hedgehog (Shh) signal transduction specifies ventral cell fates in the neural tube and is mediated by the Gli transcription factors that play both activator (GliA) and repressor (GliR) roles. Cilia are essential for Shh signal transduction and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84e59636e2ef1f2826e12078c0164e1
https://doi.org/10.1101/721399
https://doi.org/10.1101/721399
Smoothened (Smo) is the essential transducer of Sonic hedgehog (Shh) signaling, which regulates cell fate and proliferation during embryogenesis. We identified a novel mouse mutant, cabbie (cbb), and found that its cause is a missense mutation in Smo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ea40f26bbb60bf8545aaae923c15bd
https://europepmc.org/articles/PMC5903954/
https://europepmc.org/articles/PMC5903954/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(7)
Medulloblastoma (MB) is the most common malignant pediatric brain tumor, and overactivation of the Sonic Hedgehog (Shh) signaling pathway, which requires the primary cilium, causes 30% of MBs. Current treatments have known negative side effects or re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e520808928cd31f8983303a153edadbd
https://pubmed.ncbi.nlm.nih.gov/29378965
https://pubmed.ncbi.nlm.nih.gov/29378965
Autor:
Gudrun A. Rappold, Martin Blum, Hazrat Ali, Rafiullah Rafiullah, Matthias Schlesner, Tamara Caspary, Simone Berkel, Anna A. Ivanova, Richard A. Kahn, Alyssa B. Long, Ghulam Mustafa, Rebecca C. Wade, Eugen Bolthauser, Nagarajan Paramasivam, Stefan Wiemann
Publikováno v:
European journal of human genetics : EJHG. 25(12)
ARL13B encodes for the ADP-ribosylation factor-like 13B GTPase, which is required for normal cilia structure and Sonic hedgehog (Shh) signaling. Disruptions in cilia structure or function lead to a class of human disorders called ciliopathies. Jouber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645de3847ae9ed33731cde3693ae71c0
https://pubmed.ncbi.nlm.nih.gov/29255182
https://pubmed.ncbi.nlm.nih.gov/29255182
Publikováno v:
Developmental Biology. 450:63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72b1e5258aea283645e3b589bd21c226
https://doi.org/10.1016/j.ydbio.2019.02.005
https://doi.org/10.1016/j.ydbio.2019.02.005
Autor:
Kristen M. Rosenthal, Alyssa B. Long, Rafi Ahmed, Brian D. Evavold, Royce Butler, Jeremy M. Boss, Wendy M. Zinzow-Kramer, Ioanna Skountzou, Ata-Ur-Rasheed Mohammed, Benjamin Youngblood
Publikováno v:
Genes and immunity
Three distinct promoters control the master regulator of major histocompatibility complex (MHC) class II expression, class II transactivator (CIITA), in a cell type-specific manner. Promoter I (pI) CIITA, expressed primarily by dendritic cells (DCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b50152ae89c650a83eb62813206f8c9
https://doi.org/10.1038/gene.2011.86
https://doi.org/10.1038/gene.2011.86