Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Alyson B Scoltock"'
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Akademický článek
Deep sequencing identification of novel glucocorticoid-responsive miRNAs in apoptotic primary lymphocytes.
Autor: Lindsay K Smith, Arpit Tandon, Ruchir R Shah, Deepak Mav, Alyson B Scoltock, John A Cidlowski
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78316 (2013)
Apoptosis of lymphocytes governs the response of the immune system to environmental stress and toxic insult. Signaling through the ubiquitously expressed glucocorticoid receptor, stress-induced glucocorticoid hormones induce apoptosis via mechanisms
Externí odkaz: https://doaj.org/article/fa9a7755c02b4a2abce104936014526b
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2
Proinflammatory Actions of Glucocorticoids: Glucocorticoids and TNFα Coregulate Gene Expression In Vitro and In Vivo
Autor: Amy Jo Galliher-Beckley, Alyson B. Scoltock, Erica A. Lannan, John A. Cidlowski
Publikováno v: Endocrinology. 153:3701-3712
Synthetic glucocorticoids are widely used for treatment of many inflammatory diseases. However, long-term glucocorticoid treatment can cause a variety of negative side effects. A genome-wide microarray analysis was performed in human lung A549 cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cb520cbd4d4e3224d20f8cc300e96c
https://doi.org/10.1210/en.2012-1020
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3
Osmotic Stress Resistance Imparts Acquired Anti-apoptotic Mechanisms in Lymphocytes
Autor: Maria I. Sifre, John A. Cidlowski, Carl D. Bortner, Alyson B. Scoltock
Publikováno v: Journal of Biological Chemistry. 287:6284-6295
Apoptosis is a stochastic, physiological form of cell death that is characterized by unique morphological and biochemical properties. A defining feature of apoptosis in all cells is the apoptotic volume decrease or AVD, which has been considered a pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acf1bcf896e1a41142e6bc1a5749c1e
https://doi.org/10.1074/jbc.m111.293001
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5
Reciprocal epigenetic modification of histone H2B occurs in chromatin during apoptosis in vitro and in vivo
Autor: Kozo Ajiro, Lindsay K. Smith, Alyson B. Scoltock, Makoto Ashasima, John A. Cidlowski
Publikováno v: Cell death and differentiation
Histone H2B phosphorylation at Serine 14 (phosS14) has been proposed as an epigenetic marker of apoptotic cells, whereas acetylation at the adjacent Lysine 15 (acK15) is a property of non-dying cells. We investigated the relationship and the potentia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e43c7b7e3bfbe4c2abcad4b0761df89
https://doi.org/10.1038/cdd.2009.199
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6
T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways
Autor: Alyson B. Scoltock, Derek W. Cain, Carl D. Bortner, John A. Cidlowski
Publikováno v: Cell death and differentiation. 23(5)
We developed a model system to investigate apoptotic resistance in T cells using osmotic stress (OS) to drive selection of death-resistant cells. Exposure of S49 (Neo) T cells to multiple rounds of OS followed by recovery of surviving cells resulted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1c18ad7c62157a751734cbe459e480
https://pubmed.ncbi.nlm.nih.gov/26658018
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7
Activation of intrinsic and extrinsic pathways in apoptotic signaling during UV-C-induced death of Jurkat cells: the role of caspase inhibition
Autor: John A. Cidlowski, Alyson B. Scoltock
Publikováno v: Experimental Cell Research. 297:212-223
We have examined UV irradiation-induced cell death in Jurkat cells and evaluated the relationships that exist between inhibition of caspase activity and the signaling mechanisms and pathways of apoptosis. Jurkat cells were irradiated with UV-C light,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef4e19bd18663c0f96aa3b4118017f0
https://doi.org/10.1016/j.yexcr.2004.03.025
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10
Complex Human Glucocorticoid Receptor dim Mutations Define Glucocorticoid Induced Apoptotic Resistance in Bone Cells
Autor: Christine M. Jewell, John A. Cidlowski, Brant L. Hamel, Matthew R. Yudt, Alyson B. Scoltock
A mutation in the D-loop of the second zinc finger of the DNA-binding domain of the human glucocorticoid receptor (hGR), A458T (GR(dim)), has been suggested to be essential for dimerization and DNA binding of the GR, and genetically altered GR(dim) m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2e35e26462a818b805030a37351836
https://europepmc.org/articles/PMC3275167/
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