Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Alysia N. Polito"'
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Akademický článek
Identification of PIKfyve kinase as a target in multiple myeloma
Autor: Cecilia Bonolo de Campos, Yuan Xiao Zhu, Nikolai Sepetov, Sergei Romanov, Laura Ann Bruins, Chang-Xin Shi, Caleb K. Stein, Joachim L. Petit, Alysia N. Polito, Meaghen E. Sharik, Erin W. Meermeier, Gregory J. Ahmann, Ilsel D. Lopez Armenta, Jonas Kruse, P. Leif Bergsagel, Marta Chesi, Nathalie Meurice, Esteban Braggio, A. Keith Stewart
Publikováno v: Haematologica, Vol 105, Iss 6 (2020)
The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. The activity of APY0201 was confirmed in all 25 cell lines tested and in 40% of 100 ex vivo
Externí odkaz: https://doaj.org/article/36f9707664964168a6cc9caa0c85b080
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2
Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo
Autor: Nathalie Meurice, Debabrata Mukhopadhyay, Krishnendu Pal, Alysia N. Polito, Thai H. Ho, Paul D. Hanavan, Andrey A. Bobkov, Huijun Luo, Douglas O. Faigel, Shamit K. Dutta, Eduard Sergienko, Amber Fifield, John A. Copland, Erik P. Castle, Thomas R. Caulfield, Joachim L. Petit, Douglas F. Lake
Publikováno v: Molecular Cancer Therapeutics. 19:112-122
Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme overexpressed by many different tumor types. QSOX1 catalyzes the formation of disulfide bonds in proteins. Because short hairpin knockdowns (KD) of QSOX1 have been shown to suppress tumor growth and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45ab4c85fec91d4ee718f888c8fb8505
https://doi.org/10.1158/1535-7163.mct-19-0233
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3
'Direct to Drug' screening as a precision medicine tool in multiple myeloma
Autor: Shaji Kumar, Alysia N. Polito, David Dingli, Esteban Braggio, Nathalie Meurice, Kimberly J. Henderson, Jeremy T. Larsen, P. Leif Bergsagel, Joachim L. Petit, Ilsel D Lopez Armenta, Susie A. Darvish, Greg J. Ahmann, Yuan Xiao Zhu, Craig B. Reeder, Prashant Kapoor, Rafael Fonseca, William Stewart, Xuewei Wang, Jonas J. Kruse, Laura Ann Bruins, A. Keith Stewart, Shulan Tian, Cecília Bonolo de Campos, Panwen Wang
Publikováno v: Blood Cancer Journal
Blood Cancer Journal, Vol 10, Iss 5, Pp 1-16 (2020)
Seventy-six FDA-approved oncology drugs and emerging therapeutics were evaluated in 25 multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma cell lines and in 113 primary MM samples. Ex vivo drug sensitivities were mined for associations with clinica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f8e0dfaa638d56d14f713e82745aa
http://europepmc.org/articles/PMC7214452
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4
Integrative Analysis of FISH, Transcriptomics and Mutational Status Predicts Responsiveness to Novel Agents in Multiple Myeloma
Autor: Joachim L. Petit, P. Leif Bergsagel, Caleb K. Stein, Nathalie Meurice, Laura Ann Bruins, Esteban Braggio, Alysia N. Polito, Cecília Bonolo de Campos, Gregory J. Ahmann, A. Keith Stewart, Shulan Tian
Publikováno v: Blood. 134:574-574
Introduction Despite continuous improvement of clinical outcome in multiple myeloma (MM), disease relapse remains a major challenge, leading to progressively shorter remissions and fewer treatment options. Strategies attempting to counteract this cha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62fc555f5361159ae81ee223ee97f8aa
https://doi.org/10.1182/blood-2019-130977
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