Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Alysha G, Elliott"'
Autor:
Holly E. E. Floyd, Angela M. Kavanagh, Gabrielle J. Lowe, Maite Amado, James A. Fraser, Mark A. T. Blaskovich, Alysha G. Elliott, Johannes Zuegg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The Clinical and Laboratory Standards Institute (CLSI) M27 guidelines are the recommended and most commonly used protocols for broth microdilution antifungal susceptibility testing of yeasts. However, these guidelines are limited to the use
Externí odkaz:
https://doaj.org/article/5715a4a68f274e159835ad33865e4149
Autor:
Bing Zhang, Wanida Phetsang, M. Rhia L. Stone, Sanjaya Kc, Mark S. Butler, Matthew A. Cooper, Alysha G. Elliott, Urszula Łapińska, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Stefano Pagliara, Mark A. T. Blaskovich
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are desperately needed, as are research tools to aid in their discovery and development. Vancomycin is a glycopeptide antibiotic that is widely used fo
Externí odkaz:
https://doaj.org/article/91aa1c2ad9ed465bac7ff7a0422f2845
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100089- (2022)
There is a pressing need to develop new antibiotics to replace those rendered ineffective as a result of widespread antimicrobial resistance. Naturally occurring cationic antimicrobial peptides (CAMPs) exhibit broad-spectrum antibacterial activity an
Externí odkaz:
https://doaj.org/article/f238649323a0435e9df1f4a7c8f852a8
Autor:
Mark A. T. Blaskovich, Angela M. Kavanagh, Alysha G. Elliott, Bing Zhang, Soumya Ramu, Maite Amado, Gabrielle J. Lowe, Alexandra O. Hinton, Do Minh Thu Pham, Johannes Zuegg, Neil Beare, Diana Quach, Marc D. Sharp, Joe Pogliano, Ashleigh P. Rogers, Dena Lyras, Lendl Tan, Nicholas P. West, David W. Crawford, Marnie L. Peterson, Matthew Callahan, Michael Thurn
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae. This article highlig
Externí odkaz:
https://doaj.org/article/65481cd7aaae4aba9fec4f20abbf1366
Autor:
Alysha G. Elliott, Johnny X. Huang, Søren Neve, Johannes Zuegg, Ingrid A. Edwards, Amy K. Cain, Christine J. Boinett, Lars Barquist, Carina Vingsbo Lundberg, Jason Steen, Mark S. Butler, Mehdi Mobli, Kaela M. Porter, Mark A. T. Blaskovich, Sergio Lociuro, Magnus Strandh, Matthew A. Cooper
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negativ
Externí odkaz:
https://doaj.org/article/c52da634b87d440cbbc0c10a3c254c56
Autor:
Jennifer R. Baker, Peter J. Cossar, Mark A. T. Blaskovich, Alysha G. Elliott, Johannes Zuegg, Matthew A. Cooper, Peter J. Lewis, Adam McCluskey
Publikováno v:
Molecules, Vol 27, Iss 7, p 2050 (2022)
Five focused compound libraries (forty-nine compounds), based on prior studies in our laboratory were synthesized and screened for antibiotic and anti-fungal activity against S. aureus, E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, C. albicans
Externí odkaz:
https://doaj.org/article/ab332b6912d442a1883d30a187601a8c
Autor:
Mark A. T. Blaskovich, Karl A. Hansford, Yujing Gong, Mark S. Butler, Craig Muldoon, Johnny X. Huang, Soumya Ramu, Alberto B. Silva, Mu Cheng, Angela M. Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A. Bradford, June C. Lee, Tomislav Karoli, Ruby Pelingon, David J. Edwards, Maite Amado, Alysha G. Elliott, Wanida Phetsang, Noor Huda Daud, Johan E. Deecke, Hanna E. Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R. Betley, Andrew P. G. Beevers, Richard A. G. Smith, Jason A. Roberts, David L. Paterson, Matthew A. Cooper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in viv
Externí odkaz:
https://doaj.org/article/5939bc54d4b347d7b1b16946d6d5c490
Autor:
Sergii Demchenko, Roman Lesyk, Oleh Yadlovskyi, Johannes Zuegg, Alysha G. Elliott, Iryna Drapak, Yuliia Fedchenkova, Zinaida Suvorova, Anatolii Demchenko
Publikováno v:
Molecules, Vol 26, Iss 14, p 4253 (2021)
A series of novel 3-aryl-5H-pyrrolo[1,2-a]imidazole and 5H-imidazo[1,2-a]azepine quaternary salts were synthesized in 58–85% yields via the reaction of 3-aryl-6, 7-dihydro-5H-pyrrolo[1,2-a]imidazoles or 3-aryl-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]az
Externí odkaz:
https://doaj.org/article/5cecd3e055ae4b6fa612e63312473e61
Autor:
Minh Duc Cao, Son Hoang Nguyen, Devika Ganesamoorthy, Alysha G. Elliott, Matthew A. Cooper, Lachlan J. M. Coin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Assembling genomes using currently available computational methods can be time consuming. Here, Coin and colleagues describe a bioinformatics tool named npScarf that can scaffold and complete an existing short read assembly in real-time using nanopor
Externí odkaz:
https://doaj.org/article/6ae502fb25914ebfb2682688ad60502a
Autor:
Alan H. Zhang, Ingrid A. Edwards, Biswa P. Mishra, Gagan Sharma, Michael D. Healy, Alysha G. Elliott, Mark A. T. Blaskovich, Matthew A. Cooper, Brett M. Collins, Xinying Jia, Mehdi Mobli
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
The lipid composition of the cellular membrane plays an important role in a number of biological processes including the binding of membrane-active peptides. Characterization of membrane binding remains challenging, due to the technical limitations a
Externí odkaz:
https://doaj.org/article/47578dbefa25402bbf476b8f10c29f60