The Multiple Mitotic Roles of the ASPM Orthologous Proteins: Insight into the Etiology of ASPM-Dependent Microcephaly

Autor: Alyona V. Razuvaeva, Lucia Graziadio, Valeria Palumbo, Gera A. Pavlova, Julia V. Popova, Alexey V. Pindyurin, Silvia Bonaccorsi, Maria Patrizia Somma, Maurizio Gatti

Publikováno v: Cells, Vol 12, Iss 6, p 922 (2023)

The Drosophila abnormal spindle (asp) gene was discovered about 40 years ago and shown to be required for both mitotic and meiotic cell division. Subsequent studies showed that asp is highly conserved and that mutations in its human ortholog ASPM (Ab

Externí odkaz: https://doaj.org/article/b292e45b999142e0be2b9736be985ba5

Genetic Control of Kinetochore-Driven Microtubule Growth in Drosophila Mitosis

Autor: Julia V. Popova, Gera A. Pavlova, Alyona V. Razuvaeva, Lyubov A. Yarinich, Evgeniya N. Andreyeva, Alina F. Anders, Yuliya A. Galimova, Fioranna Renda, Maria Patrizia Somma, Alexey V. Pindyurin, Maurizio Gatti

Publikováno v: Cells, Vol 11, Iss 14, p 2127 (2022)

Centrosome-containing cells assemble their spindles exploiting three main classes of microtubules (MTs): MTs nucleated by the centrosomes, MTs generated near the chromosomes/kinetochores, and MTs nucleated within the spindle by the augmin-dependent p

Externí odkaz: https://doaj.org/article/5a0a4ff4291744c1991cd9ad4ca7b7bf

The multiple mitotic roles of the ASPM orthologous proteins:Insight into the etiology of ASPM-dependent microcephaly

Autor: Alyona V. Razuvaeva, Lucia Graziadio, Valeria Palumbo, Gera A. Pavlova, Julia V. Popova, Alexey V. Pindyurin, Silvia Bonaccorsi, Maria Patrizia Somma, Maurizio Gatti

Publikováno v: Razuvaeva, A V, Graziadio, L, Palumbo, V, Pavlova, G A, Popova, J V, Pindyurin, A V, Bonaccorsi, S, Somma, M P & Gatti, M 2023, ' The multiple mitotic roles of the ASPM orthologous proteins : Insight into the etiology of ASPM-dependent microcephaly ', Cells, vol. 12, no. 6, 922 . https://doi.org/10.3390/cells12060922

The Drosophila abnormal spindle (asp) gene was discovered about 40 years ago and shown to be required for both mitotic and meiotic cell division. Subsequent studies showed that asp is highly conserved and that mutations in its human ortholog ASPM (Ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341ae0b12190e09652f33770f1e9e8b8
https://hdl.handle.net/20.500.11820/259c7c88-7964-4753-902d-3985ee2317f9

RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis

Autor: Evgeniya N. Andreyeva, Claudia Pellacani, Anastasiya L. Oshchepkova, Maria Patrizia Somma, Alexey V. Pindyurin, Maurizio Gatti, Julia V. Popova, T. D. Dubatolova, Mikhail O. Lebedev, Alyona V. Razuvaeva, Gera A. Pavlova, Lyubov A. Yarinich

Publikováno v: PLoS Genetics, Vol 15, Iss 9, p e1008371 (2019)
PLoS Genetics

The Drosophila Nonspecific Lethal (NSL) complex is a major transcriptional regulator of housekeeping genes. It contains at least seven subunits that are conserved in the human KANSL complex: Nsl1/Wah (KANSL1), Dgt1/Nsl2 (KANSL2), Rcd1/Nsl3 (KANSL3),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15afd706a6a4af641d343fbaa8e37690
https://doi.org/10.1371/journal.pgen.1008371