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Autor:
Federica Orvieto, Mark J Demma, Canada Keith A, Alycia V Shoultz, Alessia Santoprete, Kuanchang Chen, Amy Bittner Mccracken, Xiaohong Zhu, Scott A. Johnson, Claudio Mapelli, Iman Farasat, Brian M. Lacey, Zachary Z Brown, Abbas Walji, Robert M. Garbaccio, Jennifer O'Neil, Elisabetta Bianchi
Publikováno v:
The Journal of organic chemistry. 85(3)
The Myc transcription factor represents an "undruggable" target of high biological interest due to its central role in various cancers. An abbreviated form of the c-Myc protein, called Omomyc, consists of the Myc DNA-binding domain and a coiled-coil