Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Alyce Bradbury"'
Autor:
Seung J. Baek, Bruce D. Hammock, In-Koo Hwang, Qing X. Li, Naima Moustaid-Moussa, Yeonhwa Park, Stephen Safe, Nanjoo Suh, Sun-Shin Yi, Darryl C. Zeldin, Qixin Zhong, Jennifer Alyce Bradbury, Matthew L. Edin, Joan P. Graves, Hyo-Young Jung, Young-Hyun Jung, Mi-Bo Kim, Woosuk Kim, Jaehak Lee, Hong Li, Jong-Seok Moon, Ik-Dong Yoo, Yiren Yue, Ji-Young Lee, Ho-Jae Han
Publikováno v:
Nutrients, Vol 13, Iss 6, p 1881 (2021)
The incidence of metabolic and chronic diseases including cancer, obesity, inflammation-related diseases sharply increased in the 21st century. Major underlying causes for these diseases are inflammation and oxidative stress. Accordingly, natural pro
Externí odkaz:
https://doaj.org/article/f7ccc095511d4edbb5dab9fbd561118d
Autor:
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175348 (2017)
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation. Epoxide h
Externí odkaz:
https://doaj.org/article/4a08af7c44cf4af8b81b993c8e239b2d
Autor:
Weibin Zha, Matthew L. Edin, Kimberly C. Vendrov, Robert N. Schuck, Fred B. Lih, Jawahar Lal Jat, J. Alyce Bradbury, Laura M. DeGraff, Kunjie Hua, Kenneth B. Tomer, John R. Falck, Darryl C. Zeldin, Craig R. Lee
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2124-2136 (2014)
Adipogenesis plays a critical role in the initiation and progression of obesity. Although cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have emerged as a potential therapeutic target for cardiometabolic disease, the functional contri
Externí odkaz:
https://doaj.org/article/b28891d15da546688f2635126a06d9ed
Autor:
Matthew L. Edin, Fred B. Lih, J. Alyce Bradbury, Darryl C. Zeldin, Joan P. Graves, Hong Li, Caroline Duval, Artiom Gruzdev
Publikováno v:
The FASEB Journal. 33:14784-14797
Inflammatory stimuli, such as bacterial LPS, alter the expression of many cytochromes P450. CYP2C and CYP2J subfamily members actively metabolize fatty acids to bioactive eicosanoids, which exhibit...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77b275f0fc82e562d073c466bc605014
https://doi.org/10.1096/fj.201901872r
https://doi.org/10.1096/fj.201901872r
Autor:
Christina Westphal, Bastian Spallek, Anne Konkel, Lajos Marko, Fatimunnisa Qadri, Laura M DeGraff, Carola Schubert, J Alyce Bradbury, Vera Regitz-Zagrosek, John R Falck, Darryl C Zeldin, Dominik N Müller, Wolf-Hagen Schunck, Robert Fischer
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73490 (2013)
Maladaptive cardiac hypertrophy predisposes one to arrhythmia and sudden death. Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) promote anti-inflammatory and antiapoptotic mechanisms, and are involved in the regulation of cardiac Ca(2+
Externí odkaz:
https://doaj.org/article/15f5ebcb62324071b24fae2120c37b4b
Autor:
Lars Bellner, Marco Raffaele, Darryl C. Zeldin, Shailendra P. Singh, Jian Cao, Nitin Puri, Nader G. Abraham, Joseph Schragenheim, J. Alyce Bradbury, Lu Liu, Luca Vanella
Publikováno v:
Prostaglandins & Other Lipid Mediators. 138:1-8
We have shown that epoxyeicosatrienoic acids (EETs), specifically 11,12- and 14,15-EETs, reduce adipogenesis in human mesenchymal stem cells and mouse preadipocytes (3T-3L1). In this study, we explore the effects of soluble epoxide hydrolase (sEH) de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5e78eb4670aa79fcbb782af3870928
https://doi.org/10.1016/j.prostaglandins.2018.07.004
https://doi.org/10.1016/j.prostaglandins.2018.07.004
Autor:
Artiom Gruzdev, Behin Gholipour Hamedani, Michael Arand, Darryl C. Zeldin, Matthew L. Edin, Samuel J. Arbes, J. Alyce Bradbury, Fred B. Lih, Rohanit Singh, Anette C. Orjuela Leon, Joan P. Graves, Laura M. DeGraff, Samantha L. Hoopes
Publikováno v:
Journal of Biological Chemistry. 293:3281-3292
Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have cardioprotective, vasodilatory, angiogenic, anti-inflammatory, and analgesic effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045cccc5c1d111a6ba9d16b3981a0903
https://doi.org/10.1074/jbc.ra117.000298
https://doi.org/10.1074/jbc.ra117.000298
Autor:
Michelle A Carey, J Alyce Bradbury, Yvette D Rebolloso, Joan P Graves, Darryl C Zeldin, Dori R Germolec
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11610 (2010)
We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice.We investigated the effects of
Externí odkaz:
https://doaj.org/article/440498e40dec41279ad44176e6fb937d
Autor:
Jessica A Wray, Mary C Sugden, Darryl C Zeldin, Gemma K Greenwood, Salma Samsuddin, Laura Miller-Degraff, J Alyce Bradbury, Mark J Holness, Timothy D Warner, David Bishop-Bailey
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7421 (2009)
Peroxisome proliferator-activated receptors (PPARs) are a family of three (PPARalpha, -beta/delta, and -gamma) nuclear receptors. In particular, PPARalpha is involved in regulation of fatty acid metabolism, cell growth and inflammation. PPARalpha med
Externí odkaz:
https://doaj.org/article/8417b0abe532426a9c9bb03ae953e418
Autor:
Artiom Gruzdev, Darryl C. Zeldin, Matthew L. Edin, J. Alyce Bradbury, Joan P. Graves, Laura M. DeGraff
Publikováno v:
Drug Metabolism and Disposition. 45:807-816
The CYP2C subfamily of the cytochrome P450 gene superfamily encodes heme-thiolate proteins that have a myriad of biologic functions. CYP2C proteins detoxify xenobiotics and metabolize endogenous lipids such as arachidonic acid to bioactive eicosanoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62357ce7b9d7cc39876fecd3afa67bb
https://doi.org/10.1124/dmd.117.075697
https://doi.org/10.1124/dmd.117.075697