Bilayer Dissolving Microneedles Incorporating Hypericin-Loaded Nanocapsules For Improved Localised Photodynamic Therapy

Autor: Heba M. Abd-El-Azim, Ismaiel Tekko, Alyaa Ramadan, Noha Nafee, Nawal Khalafallah, Ryan F Donnelly

Publikováno v: British Journal of Pharmacy, Vol 4, Iss 1 (2019)

Hypericin (Hy) is a potent lipid-soluble photosensitizer having broad pharmacological spectrum. Nevertheless, its poor water solubility leads to its aggregation in the biological systems that consequently diminishes its photodynamic activity (PDA) an

Externí odkaz: https://doaj.org/article/7eca7b1e80b14bea8b383e8645d04c46

Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer

Autor: Heba Abd-El-Azim, Ismaiel A. Tekko, Ahlam Ali, Alyaa Ramadan, Noha Nafee, Nawal Khalafallah, Taifur Rahman, William Mcdaid, Rania G. Aly, Lalitkumar K. Vora, Steven J. Bell, Fiona Furlong, Helen O. McCarthy, Ryan F. Donnelly

Publikováno v: Abd-El-Azim, H, Tekko, I A, Ali, A, Ramadan, A, Nafee, N, Khalafallah, N, Rahman, T, Mcdaid, W, Aly, R G, Vora, L K, Bell, S J, Furlong, F, McCarthy, H O & Donnelly, R F 2022, ' Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer ', Journal of controlled release : official journal of the Controlled Release Society, vol. 348, pp. 849-869 . https://doi.org/10.1016/j.jconrel.2022.06.027

Photodynamic therapy (PDT) to manage non-melanoma skin cancers has garnered great attention over the past few years. Hypericin (Hy) is a potent lipid-soluble photosensitiser with promising anticancer therapeutic activities. Nevertheless, its poor wat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc4e360d4c150364d4ebce92428fe42
https://pure.qub.ac.uk/en/publications/18cc4767-8666-4e11-8fdd-5576ba39cf17