Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Aly S. Dhala"'
Autor:
Andrea Bryant, Sandra L. Haberichter, Mia Golder, Kate Sponagle, Cynthia M. Pruss, Kimberly Laverty, Erin Burnett, Colleen Notley, Carol Hegadorn, David Lillicrap, Aly S. Dhala
Publikováno v:
Blood. 117:4358-4366
Type 1 VWD is the mild to moderate reduction of VWF levels. This study examined the mechanisms underlying 2 common type 1 VWD mutations, the severe R1205H and more moderate Y1584C. In vitro biosynthesis was reduced for both mutations in human and mou
Human von Willebrand Disease Mutations in Mouse von Willebrand Factor Alter Its Cleavage by ADAMTS13
Autor:
Colleen Notley, Rouzbeh Chegeni, Aly S. Dhala, David Lillicrap, Carol Hegadorn, Cynthia M. Pruss
Publikováno v:
Blood. 110:2708-2708
Von Willebrand Factor (VWF) is a large multimeric glycoprotein that mediates platelet adhesion to the damaged blood vessel wall and subsequent platelet aggregation at the site of vascular injury. The size of VWF multimers in plasma is regulated by th