Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Aly Elezaby"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and purine synthesis
Externí odkaz:
https://doaj.org/article/624324d27a124944b08bb5e318fbe6a2
Autor:
Nir Qvit, Amanda J. Lin, Aly Elezaby, Nicolai P. Ostberg, Juliane C. Campos, Julio C. B. Ferreira, Daria Mochly-Rosen
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 271 (2022)
Myocardial infarction is the leading cause of cardiovascular mortality, with myocardial injury occurring during ischemia and subsequent reperfusion (IR). We previously showed that the inhibition of protein kinase C delta (δPKC) with a pan-inhibitor
Externí odkaz:
https://doaj.org/article/2be3f456f88542a69f06e3d4f1657fe7
Autor:
Edward J. Miller, Timothy Calamaras, Aly Elezaby, Aaron Sverdlov, Fuzhong Qin, Ivan Luptak, Ke Wang, Xinxin Sun, Andrea Vijay, Dominique Croteau, Markus Bachschmid, Richard A. Cohen, Kenneth Walsh, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMyocardial hypertrophy and dysfunction are key features of metabolic heart disease due to dietary excess. Metabolic heart disease manifests primarily as diastolic dysfunction but may progress to systolic dysfunction, although the mechanism
Externí odkaz:
https://doaj.org/article/5e3d41148a354572bb88926c7948ce0c
Autor:
Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, Wilson S. Colucci
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundMitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Methods and
Externí odkaz:
https://doaj.org/article/cca659c2f7ae4f23b72a454022eded52
Autor:
Chunxiang Yao, Jessica B Behring, Di Shao, Aaron L Sverdlov, Stephen A Whelan, Aly Elezaby, Xiaoyan Yin, Deborah A Siwik, Francesca Seta, Catherine E Costello, Richard A Cohen, Reiko Matsui, Wilson S Colucci, Mark E McComb, Markus M Bachschmid
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144025 (2015)
Reactive protein cysteine thiolates are instrumental in redox regulation. Oxidants, such as hydrogen peroxide (H2O2), react with thiolates to form oxidative post-translational modifications, enabling physiological redox signaling. Cardiac disease and
Externí odkaz:
https://doaj.org/article/17226e23b1354d9a9df939a220b367f6
Autor:
Vijith Vijayan, Hao Yan, Juliane K. Lohmeyer, Kaylin A. Prentiss, Rachna V. Patil, Giulia Barbarito, Ivan Lopez, Aly Elezaby, Kolten Peterson, Jeanette Baker, Nicolai P. Ostberg, Alice Bertaina, Robert S. Negrin, Daria Mochly-Rosen, Kenneth Weinberg, Bereketeab Haileselassie
Despite therapeutic advancements, graft versus host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HSCT). Pathogen and damage associated molecular patterns released following pre-transplant conditioning play an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3596c5bfb77912505ae22d6eb3ee9427
https://doi.org/10.1101/2023.04.24.538141
https://doi.org/10.1101/2023.04.24.538141
Autor:
Aly Elezaby, Amanda J Lin, Vijith Vijayan, Suman Pokhrel, Luiz RG Bechara, Nicolai P Ostberg, Bruno B Queliconi, Juliane C Campos, Julio CB Ferreira, Bereketeab Haileselassie, Daria Mochly-Rosen
Cardiac troponin I (cTnI) is a sarcomeric protein critical to myocyte contraction. Unexpectedly, we found that some cTnI localized to the mitochondrial matrix in the heart, inhibited mitochondrial functions when stably expressed in non-cardiac cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf732cf7bb69c5c6e335a78e3f65f71c
https://doi.org/10.1101/2023.02.03.526715
https://doi.org/10.1101/2023.02.03.526715
Publikováno v:
Journal of Cardiac Failure. 27:822-824
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565ea96591714239b9a784d1b3f7fd30
https://doi.org/10.1016/j.cardfail.2021.04.018
https://doi.org/10.1016/j.cardfail.2021.04.018
Autor:
Xinxin Sun, Richard A. Cohen, Andrea Vijay, Dominique Croteau, Markus Bachschmid, Edward J. Miller, Fuzhong Qin, Timothy D. Calamaras, Kenneth Walsh, Wilson S. Colucci, Aaron L. Sverdlov, Ivan Luptak, Aly Elezaby, Ke Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Myocardial hypertrophy and dysfunction are key features of metabolic heart disease due to dietary excess. Metabolic heart disease manifests primarily as diastolic dysfunction but may progress to systolic dysfunction, although the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cb6514d9203a29792aa3dec8c72293
https://doi.org/10.1161/jaha.115.002277
https://doi.org/10.1161/jaha.115.002277
Autor:
Deborah A. Siwik, Markus Bachschmid, Aly Elezaby, Orian S. Shirihai, Timothy D. Calamaras, Aaron L. Sverdlov, Ivan Luptak, Fuzhong Qin, David R. Pimentel, Wilson S. Colucci, Jessica B. Behring, Marc Liesa, Richard A. Cohen, Edward J. Miller
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mitochondrial reactive oxygen species ( ROS ) are associated with metabolic heart disease ( MHD ). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD . Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b479bd062916844c4294122158d5a1d4
http://europepmc.org/articles/PMC4859372
http://europepmc.org/articles/PMC4859372