Zobrazeno 1 - 10
of 565
pro vyhledávání: '"Aly A. Khan"'
Autor:
Jean Lee, Leonid A. Yurkovetskiy, Derek Reiman, Lara Frommer, Zoe Strong, Anthony Chang, George J. Kahaly, Aly A. Khan, Alexander V. Chervonsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) display a strong female bias. Although sex hormones have been associated with protecting males from autoimmunity, the molecular mechanisms are incompletely understood. Here we re
Externí odkaz:
https://doaj.org/article/bc3a12679ae64cf6bc73934d3ee92974
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011915 (2024)
Proximity sequencing (Prox-seq) simultaneously measures gene expression, protein expression and protein complexes on single cells. Using information from dual-antibody binding events, Prox-seq infers surface protein dimers at the single-cell level. P
Externí odkaz:
https://doaj.org/article/7ae3907a73e744339ab7adbe9263b542
Autor:
Denise Lau, Sonal Khare, Michelle M. Stein, Prerna Jain, Yinjie Gao, Aicha BenTaieb, Tim A. Rand, Ameen A. Salahudeen, Aly A. Khan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Some cancer patients with impaired HLA-I still respond to immunotherapy. Here the authors combine a cytotoxic gene signature from CD4+ and CD8+ T cells with tumor mutational burden to predict immunotherapy response in NSCLC patients, including those
Externí odkaz:
https://doaj.org/article/c4b01b42753d4ca0bd0b71c82d76931e
Autor:
Yuta Asano, Joe Daccache, Dharmendra Jain, Kichul Ko, Andrew Kinloch, Margaret Veselits, Donald Wolfgeher, Anthony Chang, Michelle Josephson, Patrick Cunningham, Anat Tambur, Aly A. Khan, Shiv Pillai, Anita S. Chong, Marcus R. Clark
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Intrarenal B cells are indicative of poor prognosis in human renal allografts. Here the authors use single cell RNA sequencing to examine how intrarenal B cells contribute to renal rejection and find a population of innate B cells reactive to renal-s
Externí odkaz:
https://doaj.org/article/fda8e4a80e2a40b1a77ed6fa113be6ca
Autor:
Justin D. Finkle, Hala Boulos, Terri M. Driessen, Christine Lo, Richard A. Blidner, Ashraf Hafez, Aly A. Khan, Ariane Lozac’hmeur, Kelly E. McKinnon, Jason Perera, Wei Zhu, Afshin Dowlati, Kevin P. White, Robert Tell, Nike Beaubier
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-12 (2021)
Abstract Liquid biopsy is a valuable precision oncology tool that is increasingly used as a non-invasive approach to identify biomarkers, detect resistance mutations, monitor disease burden, and identify early recurrence. The Tempus xF liquid biopsy
Externí odkaz:
https://doaj.org/article/439e514d758c4462a85579f192a11c43
Autor:
Lei Li, Haley L. Dugan, Christopher T. Stamper, Linda Yu-Ling Lan, Nicholas W. Asby, Matthew Knight, Olivia Stovicek, Nai-Ying Zheng, Maria Lucia Madariaga, Kumaran Shanmugarajah, Maud O. Jansen, Siriruk Changrob, Henry A. Utset, Carole Henry, Christopher Nelson, Robert P. Jedrzejczak, Daved H. Fremont, Andrzej Joachimiak, Florian Krammer, Jun Huang, Aly A. Khan, Patrick C. Wilson
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 4, Pp 100056- (2021)
Summary: Multimodal advances in single-cell sequencing have enabled the simultaneous quantification of cell surface protein expression alongside unbiased transcriptional profiling. Here, we present LinQ-View, a toolkit designed for multimodal single-
Externí odkaz:
https://doaj.org/article/e699f72a78bd4f8aa796657f3bd5dcb7
Autor:
Brian M. Larsen, Madhavi Kannan, Lee F. Langer, Benjamin D. Leibowitz, Aicha Bentaieb, Andrea Cancino, Igor Dolgalev, Bridgette E. Drummond, Jonathan R. Dry, Chi-Sing Ho, Gaurav Khullar, Benjamin A. Krantz, Brandon Mapes, Kelly E. McKinnon, Jessica Metti, Jason F. Perera, Tim A. Rand, Veronica Sanchez-Freire, Jenna M. Shaxted, Michelle M. Stein, Michael A. Streit, Yi-Hung Carol Tan, Yilin Zhang, Ende Zhao, Jagadish Venkataraman, Martin C. Stumpe, Jeffrey A. Borgia, Ashiq Masood, Daniel V.T. Catenacci, Jeremy V. Mathews, Demirkan B. Gursel, Jian-Jun Wei, Theodore H. Welling, Diane M. Simeone, Kevin P. White, Aly A. Khan, Catherine Igartua, Ameen A. Salahudeen
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109429- (2021)
Summary: Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer biology and develop novel precision medicine therapeutics. However, utilizing TOs for systems-biology-based approaches has been limited by a lack of s
Externí odkaz:
https://doaj.org/article/9e05120e2cf8481abf4978520140395c
Autor:
Derek Reiman, Godhev Kumar Manakkat Vijay, Heping Xu, Andrew Sonin, Dianyu Chen, Nathan Salomonis, Harinder Singh, Aly A Khan
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008094 (2021)
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or
Externí odkaz:
https://doaj.org/article/4d4b486c110d4e0fa8b74d5347207dc6
Autor:
Sunglim Cho, Hyang-Mi Lee, I-Shing Yu, Youn Soo Choi, Hsi-Yuan Huang, Somaye Sadat Hashemifar, Ling-Li Lin, Mei-Chi Chen, Nikita D. Afanasiev, Aly Azeem Khan, Shu-Wha Lin, Alexander Y. Rudensky, Shane Crotty, Li-Fan Lu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to
Externí odkaz:
https://doaj.org/article/5b06837f8ef2466591810930fcb8fa03
Autor:
Aly A. Khan, Leonid Yurkovetskiy, Kelly O’Grady, Joseph M. Pickard, Renée de Pooter, Dionysios A. Antonopoulos, Tatyana Golovkina, Alexander Chervonsky
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 541-550.e4 (2019)
Summary: Environmental influences (infections and diet) strongly affect a host’s microbiota. However, host genetics may influence commensal communities, as suggested by the greater similarity between the microbiomes of identical twins compared to n
Externí odkaz:
https://doaj.org/article/7613ea228e1147c692789bf4f72b422a