Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Aly A. Hazzaa"'
Autor:
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Rasha A. Nassra, Saad R. El-Zemity, Aly A. Hazzaa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractNew thymol–3,4-disubstitutedthiazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 6b, 6d, 6e, and 6f displayed in vitro inhibitory activity against COX-2 (IC50= 0.037, 0.042, 0.046, and 0.039 µM) nearly equal to celec
Externí odkaz:
https://doaj.org/article/fec79da2057e482d91a08ba9a8c001f5
Autor:
Marwa E. Abdelaziz, Mostafa M. M. El-Miligy, Salwa M. Fahmy, Marwa M. Abu-Serie, Aly A. Hazzaa, Mona A. Mahran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractNew aromatic O-alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. 4c and 4f showed potent in vitro anticancer activity against NFS-60, HepG-2, PC-3, and Caco-2 cell lines and lo
Externí odkaz:
https://doaj.org/article/e162c88d829d4fc1b977203714ab0d09
Autor:
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El-Zemity, Rasha A. Nassra, Aly A. Hazzaa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 294-308 (2023)
New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC50 = 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib
Externí odkaz:
https://doaj.org/article/485b30dba1ca464192537cae444e109e
Autor:
Mostafa M. M. El-Miligy, Marwa E. Abdelaziz, Salwa M. Fahmy, Tamer M. Ibrahim, Marwa M. Abu-Serie, Mona A. Mahran, Aly A. Hazzaa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase inhibitors. Compounds 5b, 5c, 6e, 13a, 13c, and 14a showed in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer ac
Externí odkaz:
https://doaj.org/article/9e34b94d9a5b4637adf59e548997a9d7
Autor:
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El-Zemity, Rasha A. Nassra, Aly A. Hazzaa
New thymol − 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against COX-2 (IC50 = 0.043, 0.045, 0.063, and 0.068 µM) nearly equal to celecoxib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8501bd817ebdaaf26eadbff92cae524
Publikováno v:
Current Bioactive Compounds. 15:125-137
Background:Thymol has been reported to have a variety of antimicrobial and insecticidal activities but it has irritation side effect due to its phenolic nature.Methods:A new series of potential non-irritant non-phenolic thymol derivatives were design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15bdaed4055149c17df1a9f761c1c449
https://doi.org/10.2174/1573407213666171115161626
https://doi.org/10.2174/1573407213666171115161626
Autor:
Marwa M. Abu-Serie, Ahmed K. Al-Kubeisi, Mostafa M.M. El-Miligy, Saad R. El-Zemity, Aly A. Hazzaa, Rasha A. Nassra
Publikováno v:
Bioorganic chemistry. 115
Colorectal cancer (CRC) is the second cause of cancer death worldwide. Inhibitors of COX-2, 5-LOX and PIM-1 kinase were very effective in the treatment and prevention of CRC in mouse models in vivo. Furthermore, thymol was confirmed to inhibit CRC ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7089d3caa86517d6127c3e15cd8c52
https://pubmed.ncbi.nlm.nih.gov/34303896
https://pubmed.ncbi.nlm.nih.gov/34303896
Publikováno v:
Bioorganic Chemistry. 80:674-692
A series of pyridine and thieno[2,3-b]pyridine derivatives have been designed and synthesized as anticancer PIM-1 kinase inhibitors. Thirty-seven compounds were selected by NCI to be tested initially at a single dose (10 µM) in the full NCI 60 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec1c037c884e084112af501f5660728
https://doi.org/10.1016/j.bioorg.2018.07.024
https://doi.org/10.1016/j.bioorg.2018.07.024
Autor:
Soad Am El Hawash, Ashraf M Omar, Maha A El Demellawy, Abeer E. Abdel Wahab, Maryam A.Z. El-Attar, Heba A. Abd El Razik, Aly A. Hazzaa
Publikováno v:
Future medicinal chemistry. 11(13)
Aim: Cyclooxygenase-2 (COX-2) inhibition and scavenging-free radicals are important targets in cancer treatment. Materials & methods: Sulfanylpyrimidines and triazolopyrimidines were synthesized and evaluated as anticancer and antioxidant COX-1/2 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d527733bb770fd18d68db0efbe34f660
https://pubmed.ncbi.nlm.nih.gov/31469327
https://pubmed.ncbi.nlm.nih.gov/31469327
Synthesis, antibacterial evaluation, and DNA gyrase inhibition profile of some new quinoline hybrids
Autor:
Aly A. Hazzaa, Ibrahim A. Abdelwahab, El-Sayeda M. El-Khawass, Mohamed G. Bekhit, Ola H. Rizk
Publikováno v:
Archiv der Pharmazie. 352(10)
Antibiotic-resistant bacteria continue to play an important role in human health and disease. Inventive strategies are necessary to develop new therapeutic leads to challenge drug-resistance problems. From this perception, new quinoline hybrids beari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aacc5be1eed2b8db57adf9a8a31cdc3
https://pubmed.ncbi.nlm.nih.gov/31389630
https://pubmed.ncbi.nlm.nih.gov/31389630