Výsledky vyhledávání - "Aly, Ahmed Sayed Ibrahım"

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

Autor: Reeder, SM, Reuschel, EL, Bah, MA, Yun, K, Tursi, NJ, Kim, KY, Chu, J, Zaidi, FI, Yilmaz, I, Hart, RJ, Perrin, B, Xu, Z, Humeau, L, Weiner, DB, Aly, Ahmed Sayed Ibrahım

The need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success. Additionally, CD8+ T cells targeting liver-stage (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9651::416cba6bac853bd1cfadfe61c2af1b5e
https://openaccess.bezmialem.edu.tr/handle/20.500.12645/13486

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A Plasmodium /-hydrolase modulates the development of invasive stages

Autor: Groat-Carmona, Anna M., Kain, Heather, Brownell, Jessica, Douglass, Alyse N., Aly, Ahmed Sayed Ibrahım, Kappe, Stefan H. I.

The bud emergence (BEM)46 proteins are evolutionarily conserved members of the /-hydrolase superfamily, which includes enzymes with diverse functions and a wide range of substrates. Here, we identified a PlasmodiumBEM46-like protein (PBLP) and charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9651::e8ca286b8186fd470789a63d8a15c653
http://hdl.handle.net/20.500.12645/23589

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A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii

Autor: MacKellar, Drew C., Vaughan, Ashley M., Aly, Ahmed Sayed Ibrahım, DeLeon, Sasha, Kappe, Stefan H. I.

The early transcribed membrane proteins (ETRAMPs) are a family of small, highly charged transmembrane proteins unique to malaria parasites. Some members of the ETRAMP family have been localized to the parasitophorous vacuole membrane that separates t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9651::e0a13a6b1ff2a4ad537cdddef15d1ed1
http://hdl.handle.net/20.500.12645/23948

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SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages

Autor: Aly, Ahmed Sayed Ibrahım, Lindner, Scott E., MacKellar, Drew C., Peng, Xinxia, Kappe, Stefan H. I.

Plasmodium salivary gland sporozoites upregulate expression of a unique subset of genes, collectively called the UIS (upregulated in infectious sporozoites). Many UIS were shown to be essential for early liver stage development, although little is kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9651::021d6aaf385c998fd1b6bf7a3c399d08
http://hdl.handle.net/20.500.12645/23316

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Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice

Autor: Aly, Ahmed Sayed Ibrahım, Downie, Megan J., Ben Mamoun, Choukri, Kappe, Stefan H. I.

P>Repeated immunizations with whole Plasmodium blood stage parasites and concomitant drug cure of infection confer protective immunity against parasite challenge in mice, monkeys and humans. Moreover, it was recently shown that infections with geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9651::50bdad1fb5a7f9382aab9ad1f7c9c78c
http://hdl.handle.net/20.500.12645/24769

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Mitochondrial Spermidine Synthase is Essential for Blood-stage growth of the Malaria Parasite

Autor: Mohd Kamil, Umit Y. Kina, Gozde Deveci, Sevim N. Akyuz, Ilknur Yilmaz, Ahmed S.I. Aly

© 2022Positively-charged polyamines are essential molecules for the replication of eukaryotic cells and are particularly important for the rapid proliferation of parasitic protozoa and cancer cells. Unlike in Trypanosoma brucei, the inhibition of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b5e2e9ff4c7341c41621f37138674a
http://hdl.handle.net/20.500.12645/31053

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Automated wide-field malaria parasite infection detection using Fourier ptychography on stain-free thin-smears

Autor: Osman, Akcakır, Lutfi Kadir, Celebi, Mohd, Kamil, Ahmed S I, Aly

Publikováno v: Biomed Opt Express

Diagnosis of malaria in endemic areas is hampered by the lack of a rapid, stain-free and sensitive method to directly identify parasites in peripheral blood. Herein, we report the use of Fourier ptychography to generate wide-field high-resolution qua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1346c91991769ecc427ed4fdac3df3
https://europepmc.org/articles/PMC9352279/

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An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge

Autor: Paul J. F. Rider, Mohd Kamil, Ilknur Yilmaz, Habibe N. Atmaca, Merve Kalkan-Yazici, Mehmet Ziya Doymaz, Konstantin G. Kousoulas, Ahmed S. I. Aly

Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3756145b5200f85a8da24f1cb95856e1
http://hdl.handle.net/20.500.12645/30452

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