Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Alwin M, Hartman"'
1
Akademický článek
Temperature moderates impact of formulated moxidectin on seed germination of three temperate grassland species.
Autor: Carsten Eichberg, Alwin M Hartman, Alexandra-Marie Kronenberger, Rolf-Alexander Düring, Tobias W Donath
Publikováno v: PLoS ONE, Vol 17, Iss 11, p e0277865 (2022)
Formulations of macrocyclic lactone anthelmintics such as moxidectin are regularly administered to sheep to combat parasites. A disadvantage of these pharmaceuticals are their side effects on non-target organisms when entering the environment. Little
Externí odkaz: https://doaj.org/article/dc1e0c895f714592b4cfa98bbe951e2b
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2
Akademický článek
Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement
Autor: Aleksandra Zielińska, Abigail Savietto, Anabela de Sousa Borges, Denis Martinez, Melanie Berbon, Joël R Roelofsen, Alwin M Hartman, Rinse de Boer, Ida J Van der Klei, Anna KH Hirsch, Birgit Habenstein, Marc Bramkamp, Dirk-Jan Scheffers
Publikováno v: eLife, Vol 9 (2020)
The bacterial plasma membrane is an important cellular compartment. In recent years it has become obvious that protein complexes and lipids are not uniformly distributed within membranes. Current hypotheses suggest that flotillin proteins are require
Externí odkaz: https://doaj.org/article/2400d4a4315b411c93a16a876c8e59ef
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3
Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement
Autor: Joël R. Roelofsen, Denis Martinez, Alwin M. Hartman, Anna K. H. Hirsch, Marc Bramkamp, Abigail Savietto, Anabela de Sousa Borges, Birgit Habenstein, Ida J. van der Klei, Aleksandra Zielińska, Rinse de Boer, Mélanie Berbon, Dirk-Jan Scheffers
Publikováno v: eLife
International
England
eLife, Vol 9 (2020)
eLife, 9:e57179, 1-21. ELIFE SCIENCES PUBLICATIONS LTD
The bacterial plasma membrane is an important cellular compartment. In recent years it has become obvious that protein complexes and lipids are not uniformly distributed within membranes. Current hypotheses suggest that flotillin proteins are require
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa494946af289c4ce59d3543fec202cb
https://research.rug.nl/en/publications/b805006d-bbef-4e3f-bf47-ab1a6cef0ab6
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4
Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry
Autor: Nathalie Hertrich, Christian Ottmann, Alwin M. Hartman, Sebastian A. Andrei, Walid A. M. Elgaher, Anna K. H. Hirsch
Publikováno v: ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, 11(5), 1041-1046. American Chemical Society
ACS medicinal chemistry letters
United States
ACS Med Chem Lett
Bioorganic & Medicinal Chemistry Letters, 11(5), 1041-1046. American Chemical Society
[Image: see text] Protein–protein interactions (PPIs) play an important role in numerous biological processes such as cell-cycle regulation and multiple diseases. The family of 14-3-3 proteins is an attractive target as they serve as binding partne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe455c6a8c3eb7d2241238edd145c2
https://hdl.handle.net/11370/688dfb28-481c-4559-8349-2186dae144d8
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5
Temperature moderates impact of formulated moxidectin on seed germination of three temperate grassland species
Autor: Carsten, Eichberg, Alwin M, Hartman, Alexandra-Marie, Kronenberger, Rolf-Alexander, Düring, Tobias W, Donath
Publikováno v: PloS one. 17(11)
Formulations of macrocyclic lactone anthelmintics such as moxidectin are regularly administered to sheep to combat parasites. A disadvantage of these pharmaceuticals are their side effects on non-target organisms when entering the environment. Little
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9b3334c1f08d6849b92bd5e478e9f37
https://pubmed.ncbi.nlm.nih.gov/36409735
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6
Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol
Autor: Alwin M. Hartman, Anna K. H. Hirsch, Robin M. Gierse
Publikováno v: European Journal of Organic Chemistry. 2019:3581-3590
Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68ad40d6087ea841dc1c7ff1a8d84054
https://doi.org/10.1002/ejoc.201900327
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7
Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase
Autor: Evelien M Te Poele, Alwin M. Hartman, Lubbert Dijkhuizen, Anna K. H. Hirsch, Walid A. M. Elgaher, Varsha R. Jumde
Publikováno v: ChemMedChem
International
Germany
ChemMedChem, 16(1):cmdc.202000222, 113-123. WILEY-V C H VERLAG GMBH
Chemmedchem
We applied dynamic combinatorial chemistry (DCC) to find novel ligands of the bacterial virulence factor glucosyltransferase (GTF) 180. GTFs are the major producers of extracellular polysaccharides, which are important factors in the initiation and d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a5f87f5fb7f2fbdf5b2fd936d4dc02
https://hdl.handle.net/10033/622378
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9
Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments
Autor: Alwin M. Hartman, Aleksandra Świerczyńska, Zbigniew Czarnocki, Zuzanna Molęda, Anna K. H. Hirsch, Iwona Łozińska
Hybrid inhibitors of acetyl- and butyrylcholinesterase are compounds that combine structural motifs of two different classical inhibitors, leading to a dual binding ligand. A rapidly growing collection of those compounds involves a wide diversity of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5fa35c3daceab0b568713d692660e7
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10
Molecular insight into specific 14-3-3 modulators
Autor: Alwin M. Hartman, Anna K. H. Hirsch
Publikováno v: European Journal of Medicinal Chemistry. 136:573-584
The 14-3-3 protein family is implicated in several diseases and biological processes. Several recent reviews have summarised knowledge on certain aspects of 14-3-3 proteins, ranging from a historic overview to the structure, function and regulation.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85437ad40a8af26be157dc5a482a2acb
https://doi.org/10.1016/j.ejmech.2017.04.058
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