Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alwin J. van der Ham"'
Autor:
Roos van Schuijlenburg, Samaneh Azargoshasb, Clarize M. de Korne, Jeroen C. Sijtsma, Sascha Bezemer, Alwin J. van der Ham, Els Baalbergen, Fiona Geurten, Laura M. de Bes-Roeleveld, Severine C. Chevalley-Maurel, Matthias N. van Oosterom, Fijs W. B. van Leeuwen, Blandine Franke-Fayard, Meta Roestenberg
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Sporozoites (SPZ), the infective form of Plasmodium falciparum malaria, can be inoculated into the human host skin by Anopheline mosquitoes. These SPZ migrate at approximately 1 µm/s to find a blood vessel and travel to the liver
Externí odkaz:
https://doaj.org/article/2581459e4177448180bc03a9a2272c08
Autor:
Leonard R. Pelgrom, Thiago A. Patente, Frank Otto, Lonneke V. Nouwen, Arifa Ozir-Fazalalikhan, Alwin J. van der Ham, Hendrik J.P. van der Zande, Graham A. Heieis, Ramon Arens, Bart Everts
Publikováno v:
Cell Reports, Vol 40, Iss 1, Pp 111032- (2022)
Summary: How mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism, affects dendritic cell (DC) metabolism and T cell-priming capacity has primarily been investigated in vitro, but how mTORC1 regulates this in viv
Externí odkaz:
https://doaj.org/article/af5a88d5847d42b5978559763a00c5ea
Autor:
Marije E. Kuipers, Esther N.M. Nolte-‘t Hoen, Alwin J. van der Ham, Arifa Ozir-Fazalalikhan, D. Linh Nguyen, Clarize M. de Korne, Roman I. Koning, John J. Tomes, Karl F. Hoffmann, Hermelijn H. Smits, Cornelis H. Hokke
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Helminths like Schistosoma mansoni release excretory/secretory (E/S) products that modulate host immunity to enable infection. Extracellular vesicles (EVs) are among these E/S products, yet molecular mechanisms and functionality of S. mansoni EV inte
Externí odkaz:
https://doaj.org/article/62b6f2375028412695a0b1dd5cc68874
Autor:
Maria M. M. Kaisar, Leonard R. Pelgrom, Alwin J. van der Ham, Maria Yazdanbakhsh, Bart Everts
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Recently, it has become clear that short-chain fatty acids (SCFAs), and in particular butyrate, have anti-inflammatory properties. Murine studies have shown that butyrate can promote regulatory T cells via the induction of tolerogenic dendritic cells
Externí odkaz:
https://doaj.org/article/412e4d2e65254e29bec8ddec6ac5f004
Autor:
Christoph Driessen, Herman S. Overkleeft, Christopher D. Vulpe, Hesso Farhan, Marc Pilon, Celia R. Berkers, Bart Everts, Alex Loguinov, J. Thomas Hannich, Heinz Ludwig, Arnold Bolomsky, Julia Huber, Marcus Ståhlman, Jan Borén, Bogdan I. Florea, Marc Sathianathan, Lorina Büchler, Santosh Phuyal, Mario Ruiz, Alwin J. van der Ham, Esther A. Zaal, Amin Sobh, Sara C. Stolze, Andrej Besse, Lenka Besse
Cells pre-treated for 3h with 10 µM brefeldin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33552871e6e1733063c907c47c924f2a
https://doi.org/10.1158/0008-5472.22429021
https://doi.org/10.1158/0008-5472.22429021
Autor:
Christoph Driessen, Herman S. Overkleeft, Christopher D. Vulpe, Hesso Farhan, Marc Pilon, Celia R. Berkers, Bart Everts, Alex Loguinov, J. Thomas Hannich, Heinz Ludwig, Arnold Bolomsky, Julia Huber, Marcus Ståhlman, Jan Borén, Bogdan I. Florea, Marc Sathianathan, Lorina Büchler, Santosh Phuyal, Mario Ruiz, Alwin J. van der Ham, Esther A. Zaal, Amin Sobh, Sara C. Stolze, Andrej Besse, Lenka Besse
Supplementary Methods, figures and tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182275f89436b405bcad2fd645409448
https://doi.org/10.1158/0008-5472.22429033
https://doi.org/10.1158/0008-5472.22429033
Autor:
Christoph Driessen, Herman S. Overkleeft, Christopher D. Vulpe, Hesso Farhan, Marc Pilon, Celia R. Berkers, Bart Everts, Alex Loguinov, J. Thomas Hannich, Heinz Ludwig, Arnold Bolomsky, Julia Huber, Marcus Ståhlman, Jan Borén, Bogdan I. Florea, Marc Sathianathan, Lorina Büchler, Santosh Phuyal, Mario Ruiz, Alwin J. van der Ham, Esther A. Zaal, Amin Sobh, Sara C. Stolze, Andrej Besse, Lenka Besse
The HIV-protease inhibitor nelfinavir has shown broad anticancer activity in various preclinical and clinical contexts. In patients with advanced, proteasome inhibitor (PI)–refractory multiple myeloma, nelfinavir-based therapy resulted in 65% parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e901416a1a64be63e31f0e7aa9f10287
https://doi.org/10.1158/0008-5472.c.6513214.v1
https://doi.org/10.1158/0008-5472.c.6513214.v1
Autor:
Thiago A Patente, Eline C Brombacher, Graham A Heieis, Leonard R Pelgrom, Anna Zawistowska-Deniziak, Frank Otto, Arifa Ozir-Fazalalikhan, Alwin J van der Ham, Bruno A Guigas, José AM Barbuto, Bart Everts
Dendritic cells (DCs) play a crucial role in promoting tolerance through priming of regulatory T cells (Treg). Several studies indicate DC tolerogenicity is dependent on catabolic metabolism. However, the role of AMP-activated Kinase (AMPK), a key en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::591ea410013e3f3000f4a1242478ce0f
https://doi.org/10.1101/2023.02.21.528293
https://doi.org/10.1101/2023.02.21.528293
Autor:
Alwin J. van der Ham, Gestur Vidarsson, Leonie de Boer, Haneen Harbiye, Sona Allahverdiyeva, Bart Everts, Sebastiaan A. J. Zaat, Steven W. de Taeye, Willianne Hoepel, Riekelt H. Houtkooper, Michel van Weeghel, Dominique Baeten, Jeroen den Dunnen
Publikováno v:
The Journal of Immunology
Journal of immunology (Baltimore, Md., 205(12), 3400-3407. American Association of Immunologists
Journal of Immunology, 205(12), 3400-3407. AMER ASSOC IMMUNOLOGISTS
Journal of immunology (Baltimore, Md., 205(12), 3400-3407. American Association of Immunologists
Journal of Immunology, 205(12), 3400-3407. AMER ASSOC IMMUNOLOGISTS
IgG Abs are crucial for various immune functions, including neutralization, phagocytosis, and Ab-dependent cellular cytotoxicity. In this study, we identified another function of IgG by showing that IgG immune complexes elicit distinct cytokine profi
Autor:
Leonard R, Pelgrom, Thiago A, Patente, Frank, Otto, Lonneke V, Nouwen, Arifa, Ozir-Fazalalikhan, Alwin J, van der Ham, Hendrik J P, van der Zande, Graham A, Heieis, Ramon, Arens, Bart, Everts
Publikováno v:
Cell reports. 40(1)
How mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism, affects dendritic cell (DC) metabolism and T cell-priming capacity has primarily been investigated in vitro, but how mTORC1 regulates this in vivo remains