Zobrazeno 1 - 10
of 1 782
pro vyhledávání: '"Alwin D"'
Autor:
Julia E. Möhlmann, Sytze de Roock, Annelies C. Egas, Evelien ter Weijden, Martijn J. H. Doeleman, Alwin D. R. Huitema, Matthijs van Luin, Joost F. Swart
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-8 (2024)
Abstract Background Low-dose weekly methotrexate (MTX) is the mainstay of treatment in juvenile idiopathic arthritis. Unfortunately, a substantial part of patients has insufficient efficacy of MTX. A potential cause of this inadequate response is sub
Externí odkaz:
https://doaj.org/article/3c4cf1e65dd149c8a7159e0b76c02f61
Autor:
Hinke Siebinga, Berlinda J. de Wit-van der Veen, Daphne M. V. de Vries-Huizing, Wouter V. Vogel, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-24 (2024)
Abstract Background There is an unmet need for prediction of treatment outcome or patient selection for [177Lu]Lu-PSMA therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). Quantification of the tumor exposure–response r
Externí odkaz:
https://doaj.org/article/8fff240eb4dd480799fca12f85a0fb21
Autor:
Elke A. van Brandwijk, Else A. Aalbersberg, Arman S. Hosseini, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Background Steps have been taken by pharmaceutical companies to obtain marketing authorisation of PSMA ligands in the European Union. Since December 2022, Locametz® (PSMA-11, gozetotide) is licensed as kit for manual radiolabelling with gal
Externí odkaz:
https://doaj.org/article/d1af9e6243bf4d65b83e51713dbb1b7c
Autor:
Lishi Lin, Aletta P. I. Houwink, Jolanda M. van Dieren, Esther K. Wolthuis, Johannes V. van Thienen, Michiel S. van der Heijden, John B. A. G. Haanen, Jos H. Beijnen, Alwin D. R. Huitema
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Introduction Severe immune‐related adverse events (irAEs) due to immune checkpoint inhibitors (ICIs) can lead to admission to the intensive care unit (ICU). In this retrospective study, we determined the incidence, treatment patterns and s
Externí odkaz:
https://doaj.org/article/b377fea45b7f46209b1c0d057520a529
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Autor:
Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
IKZF1-deletions occur in 10-15% of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poor outcome. However, the impact of IKZF1-loss on sensitivity to drugs used in contemporary treatment protocols has remained under
Externí odkaz:
https://doaj.org/article/70f5749bff5943bb9814e9df3159f0f2
Autor:
David Damoiseaux, Frédéric Amant, Jos H. Beijnen, Shelby Barnett, Gareth J. Veal, Alwin D. R. Huitema, Thomas P. C. Dorlo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1931-1944 (2023)
Abstract Limited information is available concerning infant exposure and safety when breastfed by mothers receiving chemotherapy. Whereas defining distribution to breast milk is important to infer drug exposure, infant pharmacokinetics also determine
Externí odkaz:
https://doaj.org/article/af9a165e42b342d1ae831f5b5ee8be77
Autor:
Hinke Siebinga, Berlinda J. de Wit-van der Veen, Jos H. Beijnen, Marcel P. M. Stokkel, Thomas P. C. Dorlo, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx
Publikováno v:
EJNMMI Physics, Vol 10, Iss 1, Pp 1-18 (2023)
Abstract Background Prediction of [177Lu]Lu-HA-DOTATATE kidney and tumor uptake based on diagnostic [68Ga]Ga-HA-DOTATATE imaging would be a crucial step for precision dosing of [177Lu]Lu-HA-DOTATATE. In this study, the population pharmacokinetic (PK)
Externí odkaz:
https://doaj.org/article/7d39074066094585b56c1d2b07482192
Autor:
Hinke Siebinga, Bastiaan M. Privé, Steffie M. B. Peters, James Nagarajah, Thomas P. C. Dorlo, Alwin D. R. Huitema, Berlinda J. deWit‐van der Veen, Jeroen J. M. A. Hendrikx
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 8, Pp 1060-1071 (2023)
Abstract Studies to evaluate and optimize [177Lu]Lu‐PSMA treatment focus primarily on individual patient data. A population pharmacokinetic (PK) dosimetry model was developed to explore the potential of using imaging data as input for population PK
Externí odkaz:
https://doaj.org/article/8669aa79881c42eab0d580af6a0f9877
Autor:
Luka Verrest, Séverine Monnerat, Ahmed M Musa, Jane Mbui, Eltahir A G Khalil, Joseph Olobo, Monique Wasunna, Wan-Yu Chu, Alwin D R Huitema, Henk D F H Schallig, Fabiana Alves, Thomas P C Dorlo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 4, p e0012078 (2024)
BackgroundWith the current treatment options for visceral leishmaniasis (VL), recrudescence of the parasite is seen in a proportion of patients. Understanding parasite dynamics is crucial to improving treatment efficacy and predicting patient relapse
Externí odkaz:
https://doaj.org/article/f159d249ee9d4df7a72474193af8e333
Autor:
Hinke Siebinga, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema, Berlinda J. de Wit-van der Veen
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Background Folate intake might reduce [68Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this could affect treatme
Externí odkaz:
https://doaj.org/article/3a9b811c4b1b4b72a3fe199276077d71