Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alwin, de Jong"'
Autor:
Thijs J. Sluiter, Renée J. H. A. Tillie, Alwin de Jong, Jenny B. G. de Bruijn, Hendrika A. B. Peters, Remco van de Leijgraaf, Raghed Halawani, Michelle Westmaas, Lineke I. W. Starink, Paul H. A. Quax, Judith C. Sluimer, Margreet R. de Vries
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background Intraplaque angiogenesis occurs in response to atherosclerotic plaque hypoxia, which is driven mainly by highly metabolically active macrophages. Improving plaque oxygenation by increasing macrophage hypoxic signaling, thus stimulating int
Externí odkaz:
https://doaj.org/article/ee316734ffed498780f541b5876daa8b
Autor:
Hugo Fernandes, Alessandra Zonnari, Ricardo Abreu, Sezin Aday, Marta Barão, Inês Albino, Miguel Lino, Ana Branco, Cátia Seabra, Tânia Barata, Ermelindo C. Leal, José Guilherme Tralhão, Lino Gonçalves, Alwin de Jong, Hendrika A.B. Peters, Margreet R. de Vries, Paula da Costa Martins, Paul H.A. Quax, Lino Ferreira
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 307-327 (2022)
Endothelial cell (EC) activity is essential for tissue regeneration in several (patho)physiological contexts. However, our capacity to deliver in vivo biomolecules capable of controlling EC fate is relatively limited. Here, we screened a library of m
Externí odkaz:
https://doaj.org/article/75ed63aad54641e397aa0c2c69a05474
Autor:
Eva van Ingen, Amanda C. Foks, Tamar Woudenberg, M. Leontien van der Bent, Alwin de Jong, Philipp J. Hohensinner, Johann Wojta, Ilze Bot, Paul.H.A. Quax, Anne Yaël Nossent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1228-1239 (2021)
We have previously shown that treatment with third-generation antisense oligonucleotides against miR-494-3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage co
Externí odkaz:
https://doaj.org/article/3c732ba897314891bf7651163691b08a
Autor:
Suzanne L. Laboyrie, Margreet R. de Vries, Alwin de Jong, Hetty C. de Boer, Reshma A. Lalai, Laisel Martinez, Roberto I. Vazquez‐Padron, Joris I. Rotmans
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 16 (2022)
Background Arteriovenous fistula (AVF) maturation failure is a main limitation of vascular access. Maturation is determined by the intricate balance between outward remodeling and intimal hyperplasia, whereby endothelial cell dysfunction, platelet ag
Externí odkaz:
https://doaj.org/article/4ac23236191e44ca95256682fd05c9a8
Autor:
Alwin de Jong, Vincent Q. Sier, Hendrika A. B. Peters, Natalia K. M. Schilder, J. Wouter Jukema, Marie José T. H. Goumans, Paul H. A. Quax, Margreet R. de Vries
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
AimsVein grafts are frequently used to bypass coronary artery occlusions. Unfortunately, vein graft disease (VGD) causes impaired patency rates. ALK1 mediates signaling by TGF-β via TGFβR2 or BMP9/10 via BMPR2, which is an important pathway in fibr
Externí odkaz:
https://doaj.org/article/e151280a58d144afbb3c54ab231778f6
Autor:
Alwin de Jong, Rob C. M. de Jong, Erna A. Peters, Ramon Arens, J. Wouter Jukema, Margreet R. de Vries, Paul H. A. Quax
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2021)
Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and imm
Externí odkaz:
https://doaj.org/article/68141aef302449a18469194bd065858d
Autor:
Rory D. de Vries, Alwin de Jong, R. Joyce Verburgh, Lucie Sauerhering, Gijsbert P. van Nierop, Robert S. van Binnendijk, Albert D. M. E. Osterhaus, Andrea Maisner, Marion P. G. Koopmans, Rik L. de Swart
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Humans are infected with paramyxoviruses of different genera early in life, which induce cytotoxic T cells that may recognize conserved epitopes. This raises the question of whether cross-reactive T cells induced by antecedent paramyxovirus
Externí odkaz:
https://doaj.org/article/722e6a193a4149919c213b82b3955a5d
Autor:
Brigitta M. Laksono, Rory D. de Vries, R. Joyce Verburgh, Eline G. Visser, Alwin de Jong, Pieter L. A. Fraaij, Wilhemina L. M. Ruijs, David F. Nieuwenhuijse, Henk-Jan van den Ham, Marion P. G. Koopmans, Menno C. van Zelm, Albert D. M. E. Osterhaus, Rik L. de Swart
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The mechanisms by which measles virus infection induces transient immune suppression in humans are poorly understood. Here, Laksono and colleagues characterise the pathogenesis of measles-associated immune suppression in unvaccinated children, and sh
Externí odkaz:
https://doaj.org/article/06eac9c676eb4014b119d8038f3864c4
Autor:
Rik L. de Swart, Rory D. de Vries, Linda J. Rennick, Geert van Amerongen, Stephen McQuaid, R. Joyce Verburgh, Selma Yüksel, Alwin de Jong, Ken Lemon, D. Tien Nguyen, Martin Ludlow, Albert D. M. E. Osterhaus, W. Paul Duprex
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-11 (2017)
Measles: The efficacy of needle-free vaccine delivery Research shows that measles aerosol vaccination is effective when the vaccine is delivered to the lower respiratory tract. Measles virus is a highly contagious and potentially deadly human pathoge
Externí odkaz:
https://doaj.org/article/0697d6a8f6fd4e159492aab5b1682ba5
Autor:
Rory D de Vries, Martin Ludlow, Alwin de Jong, Linda J Rennick, R Joyce Verburgh, Geert van Amerongen, Debby van Riel, Peter R W A van Run, Sander Herfst, Thijs Kuiken, Ron A M Fouchier, Albert D M E Osterhaus, Rik L de Swart, W Paul Duprex
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006371 (2017)
Identification of cellular receptors and characterization of viral tropism in animal models have vastly improved our understanding of morbillivirus pathogenesis. However, specific aspects of viral entry, dissemination and transmission remain difficul
Externí odkaz:
https://doaj.org/article/27efe482118e40d3b683c25478a5e591