Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alwena H, Morgan"'
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101896- (2022)
Summary: We describe a modified BaseScope™ Assay protocol (ACDBio) for RNA in situ hybridization on fixed-frozen human brain tissue. The original protocol caused tissue detachment due to harsh tissue pre-treatment. We therefore optimized it to impr
Externí odkaz:
https://doaj.org/article/156ef02bc0f045ef8a98e6ab9bd81268
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Acyl-ghrelin (AG) is an orexigenic hormone that has a unique octanoyl modification on its third serine residue. It is often referred to as the “hunger hormone” due to its involvement in stimulating food intake and regulating energy homeostasis. T
Externí odkaz:
https://doaj.org/article/02ab1a4215a046db9ac13ff5f0982039
Autor:
Amanda K.E. Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa V. Santos, Fionnuala Johnston, Luke D. Roberts, Martina Sassi, Mathieu Mequinion, Romana Stark, Alex Reichenbach, Sarah H. Lockie, Mario Siervo, Owain Howell, Alwena H. Morgan, Timothy Wells, Zane B. Andrews, David J. Burn, Jeffrey S. Davies
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 7, Pp 100120- (2020)
Summary: Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plastic
Externí odkaz:
https://doaj.org/article/bbc0f91e9dda486a9282f158d171396c
Publikováno v:
Cells, Vol 11, Iss 5, p 765 (2022)
Adult hippocampal neurogenesis—the generation of new functional neurones in the adult brain—is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulat
Externí odkaz:
https://doaj.org/article/78d8a2a7c2e94b5fa184db8b0e07967a
Autor:
Alwena H. Morgan, Victoria J. Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P. Thomas, Fabien Blanchet, Vincent Piguet, Kirill Kiselyov, Valerie B. O’Donnell
Publikováno v:
Redox Biology, Vol 4, Iss C, Pp 40-47 (2015)
12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense materia
Externí odkaz:
https://doaj.org/article/166209cc600c4a0a9a69f5b2074f6b22
Autor:
Daniel, Rees, Amy L, Beynon, Mariah J, Lelos, Gaynor A, Smith, Luke D, Roberts, Lyndsey, Phelps, Stephen B, Dunnett, Alwena H, Morgan, Rowan M, Brown, Timothy, Wells, Jeffrey S, Davies
Publikováno v:
Cellular and molecular neurobiology.
The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson's disease (PD). However, the potential protective effect of acyl-ghrelin on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80c6d669b430079c54c9da5588e12d64
https://pubmed.ncbi.nlm.nih.gov/36107359
https://pubmed.ncbi.nlm.nih.gov/36107359
Autor:
Daniel Rees, Amy L. Beynon, Mariah J. Lelos, Gaynor A. Smith, Luke D. Roberts, Lyndsey Phelps, Stephen B. Dunnett, Alwena H. Morgan, Rowan M. Brown, Timothy Wells, Jeffrey S. Davies
The feeding-related hormone, acyl-ghrelin, protects dopamine neurons in murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8256a460abb03791a206464ea5633dc0
https://cronfa.swan.ac.uk/Record/cronfa59475/Download/59475__25351__9a510e4c130f45738d2458f48ed48839.pdf
https://cronfa.swan.ac.uk/Record/cronfa59475/Download/59475__25351__9a510e4c130f45738d2458f48ed48839.pdf
Publikováno v:
Cells. 11(5)
Adult hippocampal neurogenesis—the generation of new functional neurones in the adult brain—is impaired in aging and many neurodegenerative disorders. We recently showed that the acylated version of the gut hormone ghrelin (acyl-ghrelin) stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4365747796d1d94d7fe2ce13e5f33c3d
https://pubmed.ncbi.nlm.nih.gov/35269387
https://pubmed.ncbi.nlm.nih.gov/35269387
Publikováno v:
Trends in Endocrinology & Metabolism. 30:844-859
There is a close relationship between cognition and nutritional status, however, the mechanisms underlying this relationship require elucidation. The stomach hormone, ghrelin, which is released during food restriction, provides a link between circula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc61fe0f112769f5464e4f73c81bd395
https://doi.org/10.1016/j.tem.2019.07.001
https://doi.org/10.1016/j.tem.2019.07.001
The flipped classroom is a relatively new active learning pedagogical intervention, gaining popularity as a blended learning methodology. The flipped classroom comprises two distinct parts, directed learning carried out at the student's own pace away
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c96c31ed0a18f2eb5328381a4be0f61