Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Alvydas Mikulskis"'
Autor:
Anis H. Khimani, Abner M. Mhashilkar, Alvydas Mikulskis, Michael O'Malley, Jennifer Liao, Eva E. Golenko, Pat Mayer, Sunil Chada, Jeffrey B. Killian, Steven T. Lott
Publikováno v:
BioTechniques, Vol 38, Iss 5, Pp 739-745 (2005)
Biological maintenance of cells under variable conditions should affect gene expression of only certain genes while leaving the rest unchanged. The latter, termed “housekeeping genes,” by definition must reflect no change in their expression leve
Externí odkaz:
https://doaj.org/article/a6092a242a3744e8a061bb9d9e17fc00
Autor:
Scott Kuzdzal, Mary Lopez, Alvydas Mikulskis, Eva Golenko, Joseph DiCesare, Eric Denoyer, Wayne Patton, Richard Ediger, Lisa Sapp, Tillmann Ziegert, Suzanne Ackloo, Michael R. Wall, David P. Mannion, Guy della Cioppa, Gershon Wolfe, David Bennett, Simon Melov
Publikováno v:
BioTechniques, Vol 39, Iss 4, Pp 606-607 (2005)
Externí odkaz:
https://doaj.org/article/554c9fbab63c45bca2bb2ab1f5580870
Autor:
Jim McNally, Szilárd Kamondi, Daniel Kramer, Honglue Shen, Vibha Jawa, Jane Ruppel, Charles S Hottenstein, Kelli R. Phillips, Meina Liang, Michael E Hodsdon, Dong Geng, Joanne Goodman, Mohsen Rajabi Ahbari, Heather Myler, Marta Starcevic Manning, Alvydas Mikulskis, William Hallett, Haoheng Yan, Adrienne Clements-Egan, Paul Chamberlain, Qiang Qu, ZhenZhen Liu, Carol Gleason, Viswanath Devanaryan, George R Gunn, Susan M. Richards, Theresa J Goletz, Troy E. Barger, Susana Liu, Lakshmi Amaravadi, Veerle Snoeck, Joao Pedras-Vasconcelos, Kathryn Lindley, Robert Nelson, Mark Ware, Shobha Purushothama, An Song, Susan Kirshner, Brian M Janelsins, Jad Zoghbi, Steven Bowen, Ronald R. Bowsher
Publikováno v:
The AAPS Journal. 24
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving filing queries. Followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bacf181ab0fa77b1607ce8395bb2e0
https://doi.org/10.1208/s12248-021-00649-y
https://doi.org/10.1208/s12248-021-00649-y
Publikováno v:
Bioanalysis. 9:1293-1303
Aim: ImmunoPCR technology combines the advantages of specificity and robustness of a ligand binding assay with the amplification potential of PCR. We describe through three case studies a plug-and-play immuno polymerase chain reaction (iPCR) techniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb3214582d32b7bb7969e9408ade739
https://doi.org/10.4155/bio-2017-0099
https://doi.org/10.4155/bio-2017-0099
Autor:
Lakshmi Amaravadi, Ralf Gold, Sreeja Gopal, Katherine Dawson, Alvydas Mikulskis, Robert J. Fox
Publikováno v:
Multiple Sclerosis Journal. 23:1875-1883
Background: Delayed-release dimethyl fumarate (DMF) is an approved oral treatment for relapsing forms of multiple sclerosis (MS). Preclinical studies demonstrated that DMF activated the nuclear factor E2–related factor 2 (Nrf2) pathway. DMF and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caa8a471f089090338bd642bd878da4
https://doi.org/10.1177/1352458517690617
https://doi.org/10.1177/1352458517690617
Autor:
Richard Batrla, Kaj Blennow, Martin M. Bednar, Holly Soares, Leslie M. Shaw, José Luis Molinuevo, Sid E. O'Bryant, John Q. Trojanowski, Scott Ayton, Michelle M. Mielke, Anne M. Fagan, Gary Tong, Philip Scheltens, Jeffrey L. Cummings, Jeffrey Sevigny, Harald Hampel, Henrik Zetterberg, Alvydas Mikulskis, Tobias Bittner
Publikováno v:
Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2018, 136 (6), pp.821-853. ⟨10.1007/s00401-018-1932-x⟩
Molinuevo, J L, Ayton, S, Batrla, R, Bednar, M M, Bittner, T, Cummings, J, Fagan, A M, Hampel, H, Mielke, M M, Mikulskis, A, O’Bryant, S, Scheltens, P, Sevigny, J, Shaw, L M, Soares, H D, Tong, G, Trojanowski, J Q, Zetterberg, H & Blennow, K 2018, ' Current state of Alzheimer’s fluid biomarkers ', Acta Neuropathologica, vol. 136, no. 6, pp. 821-853 . https://doi.org/10.1007/s00401-018-1932-x
Acta Neuropathologica, 136(6), 821-853. Springer Verlag
Acta Neuropathologica, Springer Verlag, 2018, 136 (6), pp.821-853. ⟨10.1007/s00401-018-1932-x⟩
Molinuevo, J L, Ayton, S, Batrla, R, Bednar, M M, Bittner, T, Cummings, J, Fagan, A M, Hampel, H, Mielke, M M, Mikulskis, A, O’Bryant, S, Scheltens, P, Sevigny, J, Shaw, L M, Soares, H D, Tong, G, Trojanowski, J Q, Zetterberg, H & Blennow, K 2018, ' Current state of Alzheimer’s fluid biomarkers ', Acta Neuropathologica, vol. 136, no. 6, pp. 821-853 . https://doi.org/10.1007/s00401-018-1932-x
Acta Neuropathologica, 136(6), 821-853. Springer Verlag
International audience; Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. The number of people living with AD is predicted to increase; however, there are no disease-modifying therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7093fe64f7791e73d6dc087e8298e462
https://hal.sorbonne-universite.fr/hal-01960281
https://hal.sorbonne-universite.fr/hal-01960281
Autor:
Douglas Donaldson, Alvydas Mikulskis, David Yeung, Chase Shen, Shobha Purushothama, Shawn Ciotti, Geoffrey Kuesters, Brian Schlain, Elham Gharakhani
Publikováno v:
Journal of Immunological Methods. 437:53-63
A comprehensive cross-platform and cross-assay evaluation using nine technology platforms and four cytokine immunoassays (IL-6, TNFα, IL-17a, IL-2) was performed by comparing assay precision, sensitivity, parallelism and data correlation between pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614d5bf9daf9709190b093018d27b9c4
https://doi.org/10.1016/j.jim.2016.08.003
https://doi.org/10.1016/j.jim.2016.08.003
Autor:
Jeff Sevigny, Leslie Williams, Kate Leitermann, Alvydas Mikulskis, James Ferrero, John O'Gorman, Heather Stella
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Aducanumab (BIIB037), a human monoclonal antibody selective for aggregated forms of amyloid beta, is being investigated as a disease-modifying treatment for Alzheimer's disease (AD). Methods This randomized, double-blind, placebo-control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c669ea2f8f7c6d5c405bba6133aba86
http://europepmc.org/articles/PMC5651340
http://europepmc.org/articles/PMC5651340
Autor:
Sowmya Chollate, Paul H. Weinreb, Fang Qian, Alfred Sandrock, Omar Quintero-Monzon, Thierry Bussiere, Mahin Arastu, Melanie S. Brennan, Mingwei Li, Jan Grimm, Yaming Hang, James Ferrero, Tianle Chen, John O'Gorman, Robert Dunstan, Thomas Engber, Roger M. Nitsch, Marcel Maier, Jeff Sevigny, Ping Chiao, Kenneth J. Rhodes, Alvydas Mikulskis, Yan Ling, Robert H. Scannevin, H. Moore Arnold, Leslie Williams, Christoph Hock, Stephen Salloway
Publikováno v:
Nature
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6af16349ff35f219bea2af5a81efc0
Autor:
John Beaver, Alvydas Mikulskis, Alzheimer's Disease Neuroimaging Initiative, Richard Hargreaves, R. Matthew Hutchison, Ping Chiao, Cristian Salinas-Valenzuela, Brian B. Avants
Publikováno v:
Neurobiology of aging. 74
Amyloid beta (Aβ) deposition and cognitive decline are key features of Alzheimer's disease. The relationship between Aβ status and changes in neuronal function over time, however, remains unclear. We evaluated the effect of baseline Aβ status on r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d67db85537ab33dbabe023419c4477
https://pubmed.ncbi.nlm.nih.gov/30471630
https://pubmed.ncbi.nlm.nih.gov/30471630