Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Alvis, Brazma"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The growing number of available single-cell gene expression datasets from different species creates opportunities to explore evolutionary relationships between cell types across species. Cross-species integration of single-cell RNA-sequencin
Externí odkaz:
https://doaj.org/article/0358fae52340410ea709b929061832b1
Autor:
Esra Katkat, Yeliz Demirci, Guillaume Heger, Doga Karagulle, Irene Papatheodorou, Alvis Brazma, Gunes Ozhan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Melanoma is the deadliest form of skin cancer and develops from the melanocytes that are responsible for the pigmentation of the skin. The skin is also a highly regenerative organ, harboring a pool of undifferentiated melanocyte stem cells that proli
Externí odkaz:
https://doaj.org/article/5f92aee756d64bd5b2de22225f6c8555
Autor:
Manik Garg, Xu Li, Pablo Moreno, Irene Papatheodorou, Yuelong Shu, Alvis Brazma, Zhichao Miao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Several single-cell RNA sequencing (scRNA-seq) studies analyzing immune response to COVID-19 infection have been recently published. Most of these studies have small sample sizes, which limits the conclusions that can be made with high confi
Externí odkaz:
https://doaj.org/article/55a1b374726a4f5db7bba5e13a76da49
Autor:
Chengxin Dai, Anja Füllgrabe, Julianus Pfeuffer, Elizaveta M. Solovyeva, Jingwen Deng, Pablo Moreno, Selvakumar Kamatchinathan, Deepti Jaiswal Kundu, Nancy George, Silvie Fexova, Björn Grüning, Melanie Christine Föll, Johannes Griss, Marc Vaudel, Enrique Audain, Marie Locard-Paulet, Michael Turewicz, Martin Eisenacher, Julian Uszkoreit, Tim Van Den Bossche, Veit Schwämmle, Henry Webel, Stefan Schulze, David Bouyssié, Savita Jayaram, Vinay Kumar Duggineni, Patroklos Samaras, Mathias Wilhelm, Meena Choi, Mingxun Wang, Oliver Kohlbacher, Alvis Brazma, Irene Papatheodorou, Nuno Bandeira, Eric W. Deutsch, Juan Antonio Vizcaíno, Mingze Bai, Timo Sachsenberg, Lev I. Levitsky, Yasset Perez-Riverol
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The number of publicly available proteomics datasets is growing rapidly, but a standardized approach for describing the associated metadata is lacking. Here, the authors propose a format and a software pipeline to present and validate metadata, and i
Externí odkaz:
https://doaj.org/article/33519ff7742042fb963af4bf5ef059fa
Autor:
Andrew F. Jarnuczak, Hanna Najgebauer, Mitra Barzine, Deepti J. Kundu, Fatemeh Ghavidel, Yasset Perez-Riverol, Irene Papatheodorou, Alvis Brazma, Juan Antonio Vizcaíno
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-14 (2021)
Abstract Using 11 proteomics datasets, mostly available through the PRIDE database, we assembled a reference expression map for 191 cancer cell lines and 246 clinical tumour samples, across 13 lineages. We found unique peptides identified only in tum
Externí odkaz:
https://doaj.org/article/b91373af618f49f2b3ea1c128209c620
Autor:
Manik Garg, Dominique-Laurent Couturier, Jérémie Nsengimana, Nuno A. Fonseca, Matthew Wongchenko, Yibing Yan, Martin Lauss, Göran B. Jönsson, Julia Newton-Bishop, Christine Parkinson, Mark R. Middleton, D. Timothy Bishop, Sarah McDonald, Nikki Stefanos, John Tadross, Ismael A. Vergara, Serigne Lo, Felicity Newell, James S. Wilmott, John F. Thompson, Georgina V. Long, Richard A. Scolyer, Pippa Corrie, David J. Adams, Alvis Brazma, Roy Rabbie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The identification of prognostic biomarkers can help stratify cancer patients. Here, the authors apply deep RNA sequencing from primary melanomas coupled with long-term clinical outcome data from a prospective multicentre phase III trial, to develop
Externí odkaz:
https://doaj.org/article/c4c725539da241dab371faec795d6af6
Autor:
Natalja Kurbatova, Manik Garg, Luke Whiley, Elena Chekmeneva, Beatriz Jiménez, María Gómez-Romero, Jake Pearce, Torben Kimhofer, Ellie D’Hondt, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Dag Aarsland, Alejo Nevado-Holgado, Benjamine Liu, Stuart Snowden, Petroula Proitsi, Nicholas J. Ashton, Abdul Hye, Cristina Legido-Quigley, Matthew R. Lewis, Jeremy K. Nicholson, Elaine Holmes, Alvis Brazma, Simon Lovestone
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies to date have examined urine, the most readily available biofluid. Here we repor
Externí odkaz:
https://doaj.org/article/1bd85f619d574055ba7c1fb49956bdea
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Gliomas are the most frequent type of brain cancers and characterized by continuous proliferation, inflammation, angiogenesis, invasion and dedifferentiation, which are also among the initiator and sustaining factors of brain regeneration during rest
Externí odkaz:
https://doaj.org/article/43acdc89c30a48eba736cd1abb8e0d2c
Autor:
Yiqun Zhang, Fengju Chen, Nuno A. Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brazma, PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Chad J. Creighton, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which th
Externí odkaz:
https://doaj.org/article/cd7b2cc9b0fc4138b9abcb1d773ede39
Autor:
Xu Li, Manik Garg, Tingting Jia, Qijun Liao, Lifang Yuan, Mao Li, Zhengyu Wu, Weihua Wu, Yalan Bi, Nancy George, Irene Papatheodorou, Alvis Brazma, Huanle Luo, Shisong Fang, Zhichao Miao, Yuelong Shu
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Despite many studies on the immune characteristics of Coronavirus disease 2019 (COVID-19) patients in the progression stage, a detailed understanding of pertinent immune cells in recovered patients is lacking. We performed single-cell RNA sequencing
Externí odkaz:
https://doaj.org/article/727cbe60e5824c36a5f8870cb8df19ef