Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alvin Szeto"'
Publikováno v:
Powers, K T, Szeto, A & Berger-Schaffitzel, C H 2020, ' New insights into no-go, non-stop and nonsense-mediated mRNA decay complexes ', Current Opinion in Structural Biology, vol. 65, pp. 110-118 . https://doi.org/10.1016/j.sbi.2020.06.011
Eukaryotes possess a variety of translational control mechanisms which function in the surveillance of mRNAs, discriminating between normal and aberrant translation elongation and termination, triggering mRNA decay. The three major evolutionarily con
Autor:
Alvin Szeto, Peter A. Greer, Abdi Ghaffari, Graham P. Côté, Bruce E. Elliott, Victoria Hoskin
Publikováno v:
Molecular Biology of the Cell
Ezrin regulates proper focal adhesion and invadopodia turnover by regulating calpain-1, in part by directing its proteolytic activity toward key substrates talin, FAK, and cortactin. Ezrin-deficient tumor cells show reduced lung seeding and colonizat
Publikováno v:
Radiation Oncology (London, England)
A 67-year old man with a history of papillary thyroid cancer (PTC) presented with metastatic disease to the left colon in the form of a 6.1x1.0 cm bleeding, ulcerated mass. Radiopaque surgical clips were used as fiducial markers to localize the gross
Publikováno v:
Molecular Cancer Research. 11:A091-A091
The membrane cytoskeleton cross-linker ezrin, is frequently up-regulated in many aggressive cancer types including breast, and is linked to metastatic progression. However, the underlying molecular mechanisms that delineate how ezrin may be involved
Autor:
Kanji Nakatsu, Bruce E. Elliott, Abdi Ghaffari, Alvin Szeto, Maaike Hum, Navid Liaghati, Victoria Hoskin
Publikováno v:
Cancer Research. 73:3940-3940
Src kinase plays a critical intrinsic role in metastasis through disruption of cell-cell junctions and focal adhesions, and extrinsically by upregulation of paracrine pro-angiogenic factors such as VEGF. Ezrin, a Src substrate and membrane cytoskelet
Publikováno v:
BMC Proceedings
Background Deregulation of focal adhesion (FA) dynamics has been found to contribute to tumour progression by promoting cancer cell migration and invasion. Both focal adhesion kinase (FAK) and Src are involved in FA formation, and both interact with
Autor:
Kanji Nakatsu, Abdi Ghaffari, Maaike Hum, Navid Liaghati, Yolanda Madarnas, Victoria Hoskin, Alvin Szeto, Sandip SenGupta, Bruce E. Elliott, David P. LeBrun
Publikováno v:
Breast Cancer Research : BCR
Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced lymphangiogenesis remain poorly understo
Autor:
Bruce E. Elliott, Victoria Hoskin, Sandip SenGupta, Maaike Hum, Alvin Szeto, Navid Liaghati, Abdi Ghaffari, Kanji Nakatsu, Yolanda Madarnas
Publikováno v:
Breast Cancer Research : BCR
Introduction Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced lymphangiogenesis remain po