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pro vyhledávání: '"Alvin S. Chen"'
Autor:
Deyu Li, James C. Delaney, Charlotte M. Page, Alvin S. Chen, Cintyu Wong, Catherine L. Drennan, John M. Essigmann
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage. AlkB, one of the Escherichia coli adaptive response proteins,
Externí odkaz:
https://doaj.org/article/72c0ce95c6494c019c622d58039844e0
Autor:
Pablo A. Quintero, Marwa A. Sabe, Jason A. Freed, Alvin S. Chen, Inbar Raber, Bharath G. Rathakrishnan, Varayini Pankayatselvan, Arthur R. Garan
Publikováno v:
Case Reports in Internal Medicine. 7:11
AL amyloid cardiomyopathy is an increasingly recognized condition but arises less commonly with coexistent multiple myeloma. In this case report, we present a case of restrictive cardiomyopathy caused by AL amyloidosis and multiple myeloma, identifie
Autor:
Francois Haddad, Joshua W. Knowles, Victor F. Froelicher, Alvin S Chen, Euan A. Ashley, Marco V Perez, Matthew T. Wheeler, Rachel E. Bent
Publikováno v:
Heart (British Cardiac Society). 104(22)
ObjectiveTo identify electrocardiographic findings, especially deep Q and S waves in lead III, that differentiate athletes from patients with hypertrophic cardiomyopathy (HCM).MethodsDigital ECGs of athletes and patients with HCM followed at the Stan
Autor:
Kapil Gupta, Alvin S. Chen, Bernhard Helk, Alexander M. Klibanov, Zheng Guo, Claudia Mueller, Yu Tang, Roger A. Nassar
Publikováno v:
Guo, Z, Chen, A, Nassar, R A, Helk, B, Mueller, C, Tang, Y, Gupta, K & Klibanov, A M 2012, ' Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies ', Pharmaceutical Research, vol. 29, no. 11, pp. 3102-3109 . https://doi.org/10.1007/s11095-012-0802-9
To discover, elucidate the structure-activity relationship (SAR), and explore the mechanism of action of excipients able to drastically lower the viscosities of concentrated aqueous solutions of humanized monoclonal antibodies (MAbs). Salts prepared
Autor:
Xuedong Yang, James C. Delaney, John M. Essigmann, Deyu Li, Charlotte M. Page, Alvin S. Chen, Cintyu Wong, Catherine L. Drennan
Publikováno v:
Journal of the American Chemical Society
The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidat
Autor:
Charlotte M. Page, Deyu Li, Catherine L. Drennan, Cintyu Wong, James C. Delaney, John M. Essigmann, Alvin S. Chen
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Journal of Nucleic Acids
Journal of Nucleic Acids
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage. AlkB, one of theEscherichia coliadaptive response proteins, us