Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Alvin M. Kaye"'
Autor:
S. Katzburg, Dalia Somjen, Naftali Stern, David Hendel, Israel Yoles, Alvin M. Kaye, E. Knoll
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 104:252-258
A selective estrogen receptor modulator (SERM) is defined as a substance with dissimilar effects on different tissues: agonist in some and antagonists in others. The natural compound DT56a (Femarelle) was shown to activate estrogen receptors in human
Publikováno v:
Journal of Endocrinological Investigation. 30:91-96
Vitamin D metabolites and analogs exert a variety of biological activities, such as regulation of cellular proliferation, differentiation and energy metabolism, exerted through the brain type isozyme of creatine kinase (CK) specific activity, serving
Autor:
Sara Katzburg, Batya Gayer, Dalia Somjen, Orly Sharon, Alvin M. Kaye, David Hendel, Fortune Kohen
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 99:139-146
We have reported previously, that female-derived bone cells responded to 17beta-estradiol (E(2)) and to raloxifene (Ral), whereas male-derived cells responded only to dihydrotestosterone (DHT) when the stimulation of creatine kinase specific activity
Publikováno v:
Journal of Endocrinological Investigation. 28:910-918
We have previously demonstrated that rat bone in vivo and rat bone cells in vitro, responded sex-specifically to gonadal steroids in stimulation of the specific activity of the BB isozyme of creatine kinase (CK), a marker for hormonal responsiveness.
Publikováno v:
Bone. 30:78-84
We have demonstrated the net anabolic potential of a mid-region fragment of human parathyroid hormone (hPTH), and a protease resistant mutein derived from it, to stimulate growth of skeletal-derived tissues. The fragment hPTH (28–48), lacking the N
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 77:205-212
We have reported that multiple treatments with so-called 'non-hypercalcemic' analogs of 1 alpha,25(OH)(2) vitamin D(3) (1,25(OH)(2)D(3)) stimulate the specific activity of creatine kinase BB (CK) in ROS 17/2.8 osteoblast-like cells, and that pretreat
Publikováno v:
Journal of Endocrinological Investigation. 24:166-172
We previously reported a non-enzymatic method for isolation of human bone cells in culture that display osteoblastic features and respond to 1,25 dihydroxy vitamin D (1,25) and to parathyroid hormone (PTH). The present study was undertaken to analyze
Publikováno v:
Steroids. 63:340-343
We have reported that pretreatment with 1α, 25(OH)2D3(1,25) up-regulates responsiveness and sensitivity to 17β estradiol (E2) in osteoblast-like cells, as measured by parallel stimulation of [3H]thymidine incorporation into DNA and the specific act
Autor:
Dalia Somjen, G Mor, Karen Tordjman, Y. Amir-Zaltsman, A. Waisman, Fortune Kohen, Alvin M. Kaye
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 62:401-408
We have demonstrated previously that rat adipose tissue showed sex and depot-specific responses to gonadal steroids. The epididymal fat pad in males responded exclusively to androgens by increased specific activity of the brain type isozyme of creati
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 59:389-396
We have compared the cell and tissue selective estrogenic and antiestrogenic activities of tamoxifen, raloxifene, ICI 164,384 and a permanently ionized derivative of tamoxifen — tamoxifen methiodide (TMI). This non-steroidal antiestrogen has limite