Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alvin Joselin"'
Autor:
Jean-Louis A. Parmasad, Konrad M. Ricke, Benjamin Nguyen, Morgan G. Stykel, Brodie Buchner-Duby, Amanda Bruce, Haley M. Geertsma, Eric Lian, Nathalie A. Lengacher, Steve M. Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Jiyan Ma, Patrik Brundin, Scott D. Ryan, Maxime W. C. Rousseaux
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow nor hal
Externí odkaz:
https://doaj.org/article/3314777d4067426182b748c43099f849
Autor:
Yasmilde Rodríguez González, Fatemeh Kamkar, Paymaan Jafar-nejad, Suzi Wang, Dianbo Qu, Leticia Sanchez Alvarez, Dina Hawari, Margaret Sonnenfeld, Ruth S. Slack, Paul R. Albert, David S. Park, Alvin Joselin
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-23 (2023)
Abstract Background PFTK1/Eip63E is a member of the cyclin-dependent kinases (CDKs) family and plays an important role in normal cell cycle progression. Eip63E expresses primarily in postnatal and adult nervous system in Drosophila melanogaster but i
Externí odkaz:
https://doaj.org/article/e34f15bb20044e1ea43c89a1c762ae7a
Autor:
Doo Soon Im, Alvin Joselin, Devon Svoboda, Tesuya Takano, Maxime W. C. Rousseaux, Steve Callaghan, Ruth S. Slack, Shin-ichi Hisanaga, Roger J. Davis, David S. Park, Dianbo Qu
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal grow
Externí odkaz:
https://doaj.org/article/96f63e0ea73a4bf79a28c2d3433be87b
Autor:
Luana Naia, Catarina M. Pinho, Giacomo Dentoni, Jianping Liu, Nuno Santos Leal, Duarte M. S. Ferreira, Bernadette Schreiner, Riccardo Filadi, Lígia Fão, Niamh M. C. Connolly, Pontus Forsell, Gunnar Nordvall, Makoto Shimozawa, Elisa Greotti, Emy Basso, Pierre Theurey, Anna Gioran, Alvin Joselin, Marie Arsenian-Henriksson, Per Nilsson, A. Cristina Rego, Jorge L. Ruas, David Park, Daniele Bano, Paola Pizzo, Jochen H. M. Prehn, Maria Ankarcrona
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-s
Externí odkaz:
https://doaj.org/article/4aff891322844c2cbd9f607edd6e7c04
Autor:
Yasmilde Rodríguez González, Fatemeh Kamkar, Paymaan Jafar-nejad, Suzi Wang, Dianbo Qu, Leticia Sanchez Alvarez, Dina Hawari, Margaret Sonnenfeld, Ruth S. Slack, Paul Albert, David S. Park, Alvin Joselin
PFTK1/Eip63E is a member of the Cyclin-dependent kinases (CDKs) family and plays an important role in normal cell cycle progression. Eip63E expresses primarily in postnatal and adult nervous system in Drosophila melanogaster but its role in CNS devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e284097becc3cb7d1e59e9337ef571
https://doi.org/10.1101/2022.01.11.475789
https://doi.org/10.1101/2022.01.11.475789
Autor:
Doo Soon Im, Alvin Joselin, Devon Svoboda, Tesuya Takano, Maxime W. C. Rousseaux, Steve Callaghan, Ruth S. Slack, Shin-ichi Hisanaga, Roger J. Davis, David S. Park, Dianbo Qu
Publikováno v:
BMC biology. 20(1)
Background Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal growth cones,
Autor:
Steve M. Callaghan, Wassamon Boonying, Lisa M. Julian, Ruth S. Slack, Yasmilde Rodriguez Gonzalez, Alvin Joselin, David S. Park, Tianwen Huang, Sally L. Dunwoodie, Farzaneh Safarpour, Doo Soon Im, Dianbo Qu, Eugene Wang, En Huang
Publikováno v:
J Biol Chem
We previously reported that the cell cycle–related cyclin-dependent kinase 4–retinoblastoma (RB) transcriptional corepressor pathway is essential for stroke-induced cell death both in vitro and in vivo. However, how this signaling pathway induces
Autor:
Theurey, Pierre, Connolly, Niamh M. C., Fortunati, Ilaria, Emy, Basso, Susette, Lauwen, Ferrante, Camilla, Catarina Moreira Pinho, Alvin, Joselin, Anna, Gioran, Daniele, Bano, Park, David S., Maria, Ankarcrona, Pizzo, Paola, Prehn, Jochen H. M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3657::97b1224121e6bda930e576bfb575edee
http://hdl.handle.net/11577/3286977
http://hdl.handle.net/11577/3286977
Autor:
Steve M. Callaghan, Ruth S. Slack, Farzaneh Safarpour, Daniel Figeys, En Huang, Wassamon Boonying, Alvin Joselin, Grace O. Iyirhiaro, Yasmilde Rodriguez Gonzalez, Dianbo Qu, David S. Park, Young-Hwa Chung
Publikováno v:
Journal of neurochemistry. 150(3)
Loss of function mutations in the PTEN-induced putative kinase 1 (Pink1) gene have been linked with an autosomal recessive familial form of early onset Parkinson's disease (PD). However, the underlying mechanism(s) responsible for degeneration remain
Autor:
Alvin Joselin, Niamh M. C. Connolly, Susette Lauwen, Ilaria Fortunati, Jochen H. M. Prehn, David S. Park, Paola Pizzo, Emy Basso, Camilla Ferrante, Catarina Moreira Pinho, Pierre Theurey, Daniele Bano, Maria Ankarcrona, Anna Gioran
Publikováno v:
Aging Cell
Aging cell 18(3), e12924 (2019). doi:10.1111/acel.12924
Aging cell 18(3), e12924 (2019). doi:10.1111/acel.12924
Mitochondrial dysfunction is implicated in most neurodegenerative diseases, including Alzheimer's disease (AD). We here combined experimental and computational approaches to investigate mitochondrial health and bioenergetic function in neurons from a