Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alvin Jogasuria"'
Autor:
Won Jin Ho, Julianne N P Smith, Young Soo Park, Matthew Hadiono, Kelsey Christo, Alvin Jogasuria, Yongyou Zhang, Alyssia V Broncano, Lakshmi Kasturi, Dawn M Dawson, Stanton L Gerson, Sanford D Markowitz, Amar B Desai
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268787 (2022)
Emerging evidence implicates the eicosanoid molecule prostaglandin E2 (PGE2) in conferring a regenerative phenotype to multiple organ systems following tissue injury. As aging is in part characterized by loss of tissue stem cells' regenerative capaci
Externí odkaz:
https://doaj.org/article/1d5311542b3a499489eef5c722b323e2
Autor:
Yanqiao Zhang, Yoon Kwang Lee, Alvin Jogasuria, Prabodh Sadana, Kwangwon Lee, Min You, Jiashin Wu
Publikováno v:
Current Molecular Pharmacology. 10:226-236
Lipin-1, a mammalian phosphatidic acid phosphatase (PAP), is a bi-functional molecule involved in various signaling pathways via its function as a PAP enzyme in the triglyceride synthesis pathway and in the nucleus as a transcriptional co-regulator.
Autor:
Zhou Zhou, Michael J. Daniels, Ting Jie Ye, Alvin Jogasuria, Noah Kainrad, Min You, Gregory Bonavita
Publikováno v:
Hepatology Communications
Lipin-1 is a Mg2+-dependent phosphatidic acid phosphohydrolase involved in the generation of diacylglycerol during synthesis of phospholipids and triglycerides. Ethanol-mediated inhibitory effects on adipose-specific lipin-1 expression were associate
Autor:
Hong Shen, Min You, Chunki Kim, Yoonhee Han, Xudong Hu, Jiashin Wu, Alvin Jogasuria, Jiayou Wang
Publikováno v:
Journal of Biological Chemistry. 291:22482-22495
MitoNEET (mNT) (CDGSH iron-sulfur domain-containing protein 1 or CISD1) is an outer mitochondrial membrane protein that donates 2Fe-2S clusters to apo-acceptor proteins. In the present study, using a global mNT knock-out (mNTKO) mouse model, we inves
Autor:
Alvin Jogasuria, Jiayou Wang, Kwangwon Lee, Jiashin Wu, Hu-Quan Yin, Xudong Hu, Yan Cai, Min You, Mingjiang Xu, Bin Gao, Chunki Kim
Publikováno v:
The American Journal of Pathology. 186:2417-2428
We have previously shown that the ethanol-mediated elevation of lipocaline-2 (LCN2) is closely associated with the development of alcoholic fatty liver disease (AFLD) in mice. Herein, we aimed to understand the functional significance of LCN2 inducti
Publikováno v:
Gene expression. 18(2)
Alcoholic liver disease (ALD) is the most prevalent form of liver disease, encompassing a spectrum of progressive pathological changes from steatosis to steatohepatitis to fibrosis/cirrhosis and hepatocellular carcinoma. Alcoholic steatosis/steatohep
Autor:
Alvin Jogasuria, Roman Chrast, Jiayou Wang, Brian N. Finck, Xudong Hu, Min You, Hong Shen, Jiashin Wu, Chunki Kim, Yoonhee Han
Publikováno v:
Scientific Reports
Lipin-1 is a phosphatidate phosphohydrolase (PAP) required for the generation of diacylglycerol during glycerolipid synthesis, and exhibits dual functions in the regulation of lipid metabolism. Lipin-1 has been implicated in the pathogenesis of alcoh
Autor:
Alvin Jogasuria, Min You, Jiashin Wu, Altaf S. Darvesh, Werner J. Geldenhuys, Prabodh Sadana, Jamie R Burke
Publikováno v:
The FASEB Journal. 29
Elevated triglycerides (TGs) are an independent risk factor for cardiovascular disease (CVD). Lipoprotein lipase (LPL) found along the capillary endothelium catalyzes the hydrolysis of TG rich lipo...
Publikováno v:
Alcohol. 60:238
Publikováno v:
The American journal of pathology. 185(5)
Ethanol-mediated injury, combined with gut-derived lipopolysaccharide (LPS), provokes generation of proinflammatory cytokines in Kupffer cells, causing hepatic inflammation. Among the mediators of these effects, miR-217 aggravates ethanol-induced ste