Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alvin J L, Chia"'
Autor:
John Farrell, Sophie L. Regan, Dominic P. Williams, Neil R. Kitteringham, Alvin J. L. Chia, Laura E. Randle, Abhishek Srivastava, Christopher E. Goldring, Andrew V. Stachulski, Dean J. Naisbitt, Daniel J. Antoine, Thomas A. Baillie, Martin S. Lennard, J. Luis Castrejon, Hayley Callan, B. Kevin Park, Deepak Dalvie, R. Scott Obach
Publikováno v:
Medicinal Research Reviews. 33:985-1080
The decline in approval of new drugs during the past decade has led to a close analysis of the drug discovery process. One of the main reasons for attrition is preclinical toxicity, frequently attributed to the generation of protein-reactive drug met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1217e6dd82cee0f0556c3901275f778b
https://doi.org/10.1002/med.21273
https://doi.org/10.1002/med.21273
Autor:
Alvin J. L. Chia, Paul Morgan, B. Kevin Park, Neil R. Kitteringham, Christopher E. Goldring, Shi Quan Wong
Publikováno v:
Biochemical Pharmacology
Graphical abstract CRMs activate Nrf2, but inhibit NF-κB, and GSH depletion without covalent modification activates both Nrf2 and NF-κB. This leads to cellular protection against the potentially harmful effects of redox perturbation.
Liver inj
Liver inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0c007e61f8620064254a1c22931848
https://doi.org/10.1016/j.bcp.2010.04.004
https://doi.org/10.1016/j.bcp.2010.04.004
Autor:
Andrew V, Stachulski, Thomas A, Baillie, B Kevin, Park, R Scott, Obach, Deepak K, Dalvie, Dominic P, Williams, Abhishek, Srivastava, Sophie L, Regan, Daniel J, Antoine, Christopher E P, Goldring, Alvin J L, Chia, Neil R, Kitteringham, Laura E, Randle, Hayley, Callan, J Luis, Castrejon, John, Farrell, Dean J, Naisbitt, Martin S, Lennard
Publikováno v:
Medicinal research reviews. 33(5)
The decline in approval of new drugs during the past decade has led to a close analysis of the drug discovery process. One of the main reasons for attrition is preclinical toxicity, frequently attributed to the generation of protein-reactive drug met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d88108b8bcf52152a08943373b43a994
https://pubmed.ncbi.nlm.nih.gov/23090860
https://pubmed.ncbi.nlm.nih.gov/23090860
Autor:
Alvin J. L. Chia, John D. Hayes, B. Kevin Park, Christopher E. Goldring, Neil R. Kitteringham, Rosalind E. Jenkins, Laura E. Randle, Ian M. Copple
Publikováno v:
Hepatology (Baltimore, Md.). 48(4)
The transcription factor Nrf2 regulates the expression of numerous cytoprotective genes in mammalian cells. We have demonstrated previously that acetaminophen activates Nrf2 in mouse liver following administration of non-hepatotoxic and hepatotoxic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1ed30d3c459e9591744cb5703b4f37
https://pubmed.ncbi.nlm.nih.gov/18785192
https://pubmed.ncbi.nlm.nih.gov/18785192