Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Alvin C.H. Ma"'
Autor:
Shisan Xu, Gary Tse, Fangjing Xie, Kin Fung Wong, Li Tian, Kazi Md Mahmudul Hasan, Shuk Han Cheng, Lei Sun, Alvin C.H. Ma, Yingying Lu, Jianbo Yue, Sinai H. C. Manno
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism of its action is not well understood. Here, we used an adult zebrafish model of heart cryoin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6980aa8dfd6c9d91bcf6da40c41c39c7
https://doaj.org/article/84ea43b53dcc47779a307ebbaf94cfed
https://doaj.org/article/84ea43b53dcc47779a307ebbaf94cfed
Publikováno v:
Autophagy
1-phenyl 2-thiourea (PTU) is a Tyr (tyrosinase) inhibitor that is extensively used to block pigmentation and improve optical transparency in zebrafish (Danio rerio) embryo. Here, we reported a previously undescribed effect of PTU on macroautophagy/au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc08d0940733dc5ba2caf2dcad8e1af
https://doi.org/10.1080/15548627.2020.1755119
https://doi.org/10.1080/15548627.2020.1755119
Autor:
Bai-Liang He, Alvin C.H. Ma, May P.L. Cheung, Toni K. Man, Nelson K. L. Ng, Yuhan Guo, Dandan Wang, Xiangguo Shi, Anskar Y.H. Leung, Bowie Yik Ling Cheng
Publikováno v:
Stem Cell Reports
Summary ADP-ribosylation factor-like 4aa (Arl4aa) is a member of the ADP-ribosylation factor family. It is expressed in hematopoietic tissue during embryonic development, but its function was unknown. Zebrafish arl4aa is preferentially expressed in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820c466feb1a828faaacceaba64edbdb
https://doi.org/10.1016/j.stemcr.2020.02.012
https://doi.org/10.1016/j.stemcr.2020.02.012
Autophagy is an evolutionary conserved and dynamic lysosomal degradation process for cellular homeostasis and remodelling, which is essential for the development and maintenance of different hematopoietic fates. However, the roles of autophagy in def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95ad3308d536d8ffefa73ec9582b6b38
https://doi.org/10.1101/2021.06.14.448302
https://doi.org/10.1101/2021.06.14.448302
Autor:
Gordon Tin Chun Wong, Zhen Ni Yi, Joseph Kwan, Alvin C.H. Ma, Xiang Ke Chen, Kazi Md Mahmudul Hasan, Raymond Chuen-Chung Chang
Publikováno v:
Aging Cell
Cellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b50398d2191c6a3ecbaf988470fe21
https://doi.org/10.1111/acel.13294
https://doi.org/10.1111/acel.13294
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d754710fa27fed91f040aba77ba6ede6
https://doi.org/10.1002/alz.047639
https://doi.org/10.1002/alz.047639
Autor:
Alvin C.H. Ma, Xiang Ke Chen, Gordon Tin Chun Wong, Kazi Md Mahmudul Hasan, Joseph Kwan, Zhen-Ni Yi, Raymond Chuen-Chung Chang
Background: Infiltration of macrophages into the central nervous system (CNS) is involved in many neurological disorders, such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and autism. Despite extensive studies into neuroinflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91bad4c25afcbdb0e9c0f5b6692fcfc6
https://doi.org/10.21203/rs.3.rs-96577/v1
https://doi.org/10.21203/rs.3.rs-96577/v1
Autor:
Bai-Liang He, Alvin C.H. Ma, Chun Xiao Zhang, Ho Ching Leung, Stephen S. Y. Lam, Bowie Yik Ling Cheng, Cheuk Him Man, H Kwok, Chae Yin Cher, Rakesh Sharma, Grace H W Cheng, Nelson K. L. Ng, Leo Lai Hok Kan, Anskar Y.H. Leung, Ning Yang, Michelle Lu Lu Wang, Yok-Lam Kwong, Chi Wai Eric So
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
EMBO Mol Med
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
EMBO Mol Med
EMBO Molecular Medicine
Internal tandem duplication of Fms‐like tyrosine kinase 3 (FLT3/ITD) occurs in about 30% of acute myeloid leukemia (AML) and is associated with poor response to conventional treatment and adverse outcome. Here, we reported that human FLT3/ITD expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e1919055f79762c427653b901a7bc3
https://doi.org/10.15252/emmm.201910895
https://doi.org/10.15252/emmm.201910895
Autor:
Steven Lim Cho Pei, Mullin H.C. Yu, Yiu-fai Cheung, Kit San Yeung, Xiangke Chen, Alvin C.H. Ma, Kazi Md Mahmudul Hasan, Brian H.Y. Chung, Dingge Ying, Christopher C.Y. Mak, Pak Cheong Chow
Publikováno v:
Circulation. Genomic and Precision Medicine
Supplemental Digital Content is available in the text.
Background: Human heterotaxy is a group of congenital disorders characterized by misplacement of one or more organs according to the left-right axis. The genetic causes of human heterotaxy a
Background: Human heterotaxy is a group of congenital disorders characterized by misplacement of one or more organs according to the left-right axis. The genetic causes of human heterotaxy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46333320dfca72a90cb953acb34c42f
http://europepmc.org/articles/PMC7748040
http://europepmc.org/articles/PMC7748040
Autor:
Carla M. Mann, Stephen C. Ekker, Karl J. Clark, Gabriel Martínez-Gálvez, Hirotaka Ata, Kyle J. Schaefbauer, Drena Dobbs, Thomas L. Ekstrom, Alexey V. Dvornikov, Alvin C.H. Ma
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 9, p e1007652 (2018)
PLoS Genetics, Vol 14, Iss 9, p e1007652 (2018)
One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e82dd2355f4fe02fabf290ea6daf703
http://europepmc.org/articles/PMC6152997
http://europepmc.org/articles/PMC6152997