Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Alvin C Powers"'
Autor:
John Virostko, Richard C Craddock, Jonathan M Williams, Taylor M Triolo, Melissa A Hilmes, Hakmook Kang, Liping Du, Jordan J Wright, Mara Kinney, Jeffrey H Maki, Milica Medved, Michaela Waibel, Thomas W H Kay, Helen E Thomas, Siri Atma W Greeley, Andrea K Steck, Daniel J Moore, Alvin C Powers
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256029 (2021)
Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas ima
Externí odkaz:
https://doaj.org/article/dbc9dc62256a40189372bb1641b4d5fe
Autor:
Baqiyyah N Conway, Xijing Han, Heather M Munro, Amy L Gross, Xiao-Ou Shu, Margaret K Hargreaves, Wei Zheng, Alvin C Powers, William J Blot
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190993 (2018)
BACKGROUND:Obesity is known to be a major risk factor for diabetes, but the magnitude of risk and variation between blacks and whites are less well documented in populations heavily affected by obesity. Herein we assess rates and risks of incident di
Externí odkaz:
https://doaj.org/article/b89a65d32aec42ebb8db7cd810229c66
Autor:
Nicolas Damond, Fabrizio Thorel, Julie S Moyers, Maureen J Charron, Patricia M Vuguin, Alvin C Powers, Pedro L Herrera
Publikováno v:
eLife, Vol 5 (2016)
Glucagon secretion dysregulation in diabetes fosters hyperglycemia. Recent studies report that mice lacking glucagon receptor (Gcgr-/-) do not develop diabetes following streptozotocin (STZ)-mediated ablation of insulin-producing β-cells. Here, we s
Externí odkaz:
https://doaj.org/article/b5336ac240d94ff58a8df5bdcb8a68d4
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158825 (2016)
This study harnessed the electronic medical record to assess pancreas volume in patients with type 1 diabetes (T1D) and matched controls to determine whether pancreas volume is altered in T1D and identify covariates that influence pancreas volume.Thi
Externí odkaz:
https://doaj.org/article/7f2649982eff40ae97ddcea6c4c6daf6
Autor:
Aanchal Mongia, Fatema Tuz Zohora, Noah G. Burget, Yeqiao Zhou, Diane C. Saunders, Yue J. Wang, Marcela Brissova, Alvin C. Powers, Klaus H. Kaestner, Golnaz Vahedi, Ali Naji, Gregory W. Schwartz, Robert B. Faryabi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cellular composition and anatomical organization influence normal and aberrant organ functions. Emerging spatial single-cell proteomic assays such as Image Mass Cytometry (IMC) and Co-Detection by Indexing (CODEX) have facilitated the study
Externí odkaz:
https://doaj.org/article/19cd13bfd98d4db8ba44dc36c54204c9
Autor:
Manishkumar Patel, Alexa Gleason, Stacey O'Malley, Brett Connolly, Donna Suresch, John Virostko, Neil Phillips, Shu-An Lin, Tsing-Bau Chen, Michael Klimas, Richard J Hargreaves, Cyrille Sur, David L Williams, Alvin C Powers, Bohumil Bednar
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106693 (2014)
BACKGROUND:Type 2 diabetes results from failure of the β-cells to compensate for increased insulin demand due to abnormal levels of metabolic factors. The ob/ob(lep-/-) mouse has been extensively studied as an animal model of type 2 diabetes. Previo
Externí odkaz:
https://doaj.org/article/b351acae3b4d448490f7d29ab48b6176
Autor:
Xiangni Wu, Pin-I Chen, Robert L. Whitener, Matthew S. MacDougall, Vy M. N. Coykendall, Hao Yan, Yong Bin Kim, William Harper, Shiva Pathak, Bettina P. Iliopoulou, Allison Hestor, Diane C. Saunders, Erick Spears, Jean Sévigny, David M. Maahs, Marina Basina, Seth A. Sharp, Anna L. Gloyn, Alvin C. Powers, Seung K. Kim, Kent P. Jensen, Everett H. Meyer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of Tregs is being clinically evaluated as a novel way to prevent or tr
Externí odkaz:
https://doaj.org/article/9eb5d3e2468049a48285a66700ca2b17
Autor:
John Virostko, Armandla Radhika, Greg Poffenberger, Adrienne N Dula, Daniel J Moore, Alvin C Powers
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57784 (2013)
We generated a mouse model (MIP-Luc-VU-NOD) that enables non-invasive bioluminescence imaging (BLI) of beta cell loss during the progression of autoimmune diabetes and determined the relationship between BLI and disease progression. MIP-Luc-VU-NOD mi
Externí odkaz:
https://doaj.org/article/58031ee0b9074df78da445c8b741b4ca
Autor:
Rachel B Reinert, Jeannelle Kantz, Amanda Ackermann Misfeldt, Greg Poffenberger, Maureen Gannon, Marcela Brissova, Alvin C Powers
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33529 (2012)
Tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation and lineage tracing studies in mice. Although the efficiency of inducible Cre-loxP recombination can be easily evaluated with reporter strains, the precise length
Externí odkaz:
https://doaj.org/article/b9e7bb40d84141a3b8e2577ced53c7fa
Autor:
Yulong Gong, Bingyuan Yang, Dingdong Zhang, Yue Zhang, Zihan Tang, Liu Yang, Katie C. Coate, Linlin Yin, Brittney A. Covington, Ravi S. Patel, Walter A. Siv, Katelyn Sellick, Matthew Shou, Wenhan Chang, E. Danielle Dean, Alvin C. Powers, Wenbiao Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Insufficient glucagon signalling results in hyperaminoacidemia, which drives adaptive proliferation of glucagon-producing α cells. Here the authors report that the amino acid sensitive calcium sensing receptor (CaSR) is necessary for α cell prolife
Externí odkaz:
https://doaj.org/article/654699dbaee24375b1033c131a876439