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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.

Autor: Alverez C; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Bulfer SL; Department of Pharmaceutical Chemistry, Small Molecule Discovery Center, University of California , San Francisco, California 94158, United States., Chakrasali R; Department of Medicinal Chemistry, and the Institute for Therapeutics Discovery and Development, University of Minnesota , Minneapolis, Minnesota 55414, United States., Chimenti MS; Department of Pharmaceutical Chemistry, Small Molecule Discovery Center, University of California , San Francisco, California 94158, United States., Deshaies RJ; Division of Biology and Biological Engineering, California Institute of Technology and Howard Hughes Medical Institute , Pasadena, California 91007, United States., Green N; Leidos Biomedical Research, Inc. , Frederick, Maryland 21702, United States., Kelly M; Department of Pharmaceutical Chemistry, Small Molecule Discovery Center, University of California , San Francisco, California 94158, United States., LaPorte MG; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States., Lewis TS; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States., Liang M; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Moore WJ; Leidos Biomedical Research, Inc. , Frederick, Maryland 21702, United States., Neitz RJ; Department of Pharmaceutical Chemistry, Small Molecule Discovery Center, University of California , San Francisco, California 94158, United States., Peshkov VA; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States., Walters MA; Department of Medicinal Chemistry, and the Institute for Therapeutics Discovery and Development, University of Minnesota , Minneapolis, Minnesota 55414, United States., Zhang F; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States., Arkin MR; Department of Pharmaceutical Chemistry, Small Molecule Discovery Center, University of California , San Francisco, California 94158, United States., Wipf P; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Huryn DM; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States; University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Dec 22; Vol. 7 (2), pp. 182-7. Date of Electronic Publication: 2015 Dec 22 (Print Publication: 2016).