Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Alvaro Valin"'
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Akademický článek
IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms
Autor: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado, José L. Pablos
Publikováno v: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target
Externí odkaz: https://doaj.org/article/d966f2637fe742f6aedba0c75a9ebd6b
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2
Akademický článek
The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation
Autor: Alvaro Valin, José L. Pablos
Publikováno v: Biomolecules, Vol 5, Iss 4, Pp 2723-2757 (2015)
Chronic inflammation is a common process connecting pathologies that vary in their etiology and pathogenesis such as cancer, autoimmune diseases, and infections. The response of the immune system to tissue damage involves a carefully choreographed se
Externí odkaz: https://doaj.org/article/9c969fb138a94a04a5f2fe532fd498b2
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3
Il6/Sil6R Regulates Tnfα-Inflammatory Response In Synovial Fibroblasts Through Modulation of Transcriptional and Post-Transcriptional Mechanisms
Autor: Marina Romero, Yolanda Ruano, José L. Pablos, Francisco J. Blanco, Alicia Usategui, Cristina Municio, Alvaro Valin, Gabriel Criado, Jesús Fernández-Felipe, Juan D. Cañete, Manuel J. Del Rey
Publikováno v: BMC Molecular and Cell Biology
RUC. Repositorio da Universidade da Coruña
instname
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-12 (2020)
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)
Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ff462129737279ed2447ac4a13bdce
https://doi.org/10.21203/rs.3.rs-32228/v1
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4
Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
Autor: María Galindo, José M. Cuezva, Carmen M. García-Herrero, Francisco J. Blanco, Manuel J. Del Rey, Juan D. Cañete, Alicia Usategui, Beatriz Bravo, María Sánchez-Aragó, José L. Pablos, Alvaro Valin, Gabriel Criado
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
RUC. Repositorio da Universidade da Coruña
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
Digital.CSIC. Repositorio Institucional del CSIC
Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29b83d767cff20bced9bbf700ac251c
https://doaj.org/article/e4ee554040b04e408dfa0f0ad44bfcfc
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5
Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
Autor: José L. Pablos, Cristina Municio, Alicia Usategui, Manuel J. Del Rey, Francisco J. Blanco, Sandra Ergueta, Gabriel Criado, Eduardo Martín, Alvaro Valin, Juan D. Cañete
Publikováno v: Immunity & Ageing : I & A
Immunity & Ageing, Vol 16, Iss 1, Pp 1-9 (2019)
RUC. Repositorio da Universidade da Coruña
instname
BackgroundAccumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence in human synovial tissues (ST), and its im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923fcdc02cf93bf315fc408777069d25
https://hdl.handle.net/2183/25148
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6
The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation
Autor: José L. Pablos, Alvaro Valin
Publikováno v: Biomolecules
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Biomolecules, Vol 5, Iss 4, Pp 2723-2757 (2015)
Chronic inflammation is a common process connecting pathologies that vary in their etiology and pathogenesis such as cancer, autoimmune diseases, and infections. The response of the immune system to tissue damage involves a carefully choreographed se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee053b90aacb89c0a83023dfb86f61d1
https://doi.org/10.3390/biom5042723
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7
Enforcing the pause: Transcription factor Sp3 limits productive elongation by RNA polymerase II
Autor: Alvaro Valin, Grace Gill
Publikováno v: Cell Cycle. 12:1828-1834
The transition of paused RNA polymerase II into productive elongation is a highly dynamic process that serves to fine-tune gene expression in response to changing cellular environments. We have recently reported that the transcription factor Sp3 inhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53f8116761d2c756078cf3a1c9a60a4
https://doi.org/10.4161/cc.24992
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8
Transcription Factor Sp3 Represses Expression of p21CIP1 via Inhibition of Productive Elongation by RNA Polymerase II
Autor: Grace Gill, Jian Ouyang, Alvaro Valin
Publikováno v: Molecular and Cellular Biology. 33:1582-1593
Like that of many protein-coding genes, expression of the p21(CIP1) cell cycle inhibitor is regulated at the level of transcription elongation. While many transcriptional activators have been shown to stimulate elongation, the mechanisms by which pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e50d49767e54e9672e7ad04156c3be
https://doi.org/10.1128/mcb.00323-12
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9
Direct Binding of CoREST1 to SUMO-2/3 Contributes to Gene-Specific Repression by the LSD1/CoREST1/HDAC Complex
Autor: Grace Gill, Yan Xuan, Jian Ouyang, Yujiang Shi, Alvaro Valin
Publikováno v: Molecular Cell. 34:145-154
Summary Posttranslational modification of transcription factors by the small ubiquitin-related modifier SUMO is associated with transcriptional repression, but the underlying mechanisms remain incompletely described. We have identified binding of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc0ac7856f360eff1b0735557545247
https://doi.org/10.1016/j.molcel.2009.03.013
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10
Regulation of the dual-function transcription factor Sp3 by SUMO
Autor: Grace Gill, Alvaro Valin
Publikováno v: Biochemical Society Transactions. 35:1393-1396
In eukaryotes, gene expression is controlled by a relatively small number of regulators. Post-translational modifications dramatically increase the functional possibilities of those regulators. Modification of many transcription factors and cofactors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c4725c94f3df4b05a418730093f8ba
https://doi.org/10.1042/bst0351393
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