Immune Checkpoint Inhibitors: The Emerging Cornerstone in Cholangiocarcinoma Therapy?

Autor: María Gutiérrez-Larrañaga, Elena González-López, Adriel Roa-Bautista, Pedro M. Rodrigues, Álvaro Díaz-González, Jesus M. Banales, Marcos López-Hoyos, Alvaro Santos-Laso, Javier Crespo

Publikováno v: Liver Cancer, Pp 1-16 (2021)

Background: Cholangiocarcinoma (CCA) encompasses a heterogeneous group of malignant tumors with dismal prognosis and increasing incidence worldwide. Both late diagnosis due to the lack of early symptoms and the refractory nature of these tumors serio

Externí odkaz: https://doaj.org/article/2b37b2a9b2e24e5d9bf967a229fdd4b0

The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma

Autor: Monika Lewinska, PhD, Alvaro Santos-Laso, PhD, Enara Arretxe, PhD, Cristina Alonso, PhD, Ekaterina Zhuravleva, PhD, Raul Jimenez-Agüero, MD, PhD, Emma Eizaguirre, MD, PhD, María Jesús Pareja, MD, PhD, Manuel Romero-Gómez, MD, PhD, Marco Arrese Jimenez, MD, PhD, Malte P. Suppli, MD, PhD, Filip K. Knop, MD, PhD, Stine Karlsen Oversoe, MD, PhD, Gerda Elisabeth Villadsen, MD, PhD, Thomas Decaens, MD, PhD, Flair Jose Carrilho, MD, PhD, Claudia PMS de Oliveira, MD, PhD, Bruno Sangro, MD, PhD, Rocio I.R. Macias, MD, PhD, Jesus M. Banales, PhD, Jesper B. Andersen, PhD

Publikováno v: EBioMedicine, Vol 73, Iss , Pp 103661- (2021)

Background: Non-alcoholic fatty liver disease (NAFLD) is affecting more people globally. Indeed, NAFLD is a spectrum of metabolic dysfunctions that can progress to hepatocellular carcinoma (NAFLD-HCC). This development can occur in a non-cirrhotic li

Externí odkaz: https://doaj.org/article/a98663c5714b4b39a2da1a493b1539b3

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

Autor: Ainhoa Lapitz, Ander Arbelaiz, Colm J. O’Rourke, Jose L. Lavin, Adelaida La Casta, Cesar Ibarra, Juan P. Jimeno, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Marcin Krawczyk, Maria J. Perugorria, Raul Jimenez-Aguero, Alberto Sanchez-Campos, Ioana Riaño, Esperanza Gónzalez, Frank Lammert, Marco Marzioni, Rocio I.R. Macias, Jose J. G. Marin, Tom H. Karlsen, Luis Bujanda, Juan M. Falcón-Pérez, Jesper B. Andersen, Ana M. Aransay, Pedro M. Rodrigues, Jesus M. Banales

Publikováno v: Cells, Vol 9, Iss 3, p 721 (2020)

Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and ac

Externí odkaz: https://doaj.org/article/3b3b763b3a064cf0b5e939942071ce9a

Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma

Autor: Julen Oyarzabal, Robert Arnes-Benito, Leticia Colyn, Jose J.G. Marin, Jose M Herranz, Maite G. Fernandez-Barrena, María J. Iraburu, Maria Francesconi, Gloria Alvarez-Sola, Meritxell Huch, Leonard J Nelson, Francisco Javier Cubero, Matías A. Avila, Altaf A. Dar, Jesus M. Banales, Iker Uriarte, Mikel Ruiz de Gauna, Simone Carotti, Jesús Urman, Sergio Morini, María L. Martínez-Chantar, Chaobo Chen, Marina Bárcena-Varela, Eva Santamaría, Andrea Casadei-Gardini, Christian Trautwein, Patricia Aspichueta, Alvaro Santos-Laso, Carmen Berasain, Felipe Prosper, Bruno Sangro, John M Patino, Matteo Canale, Mehdi Nosrati, María Arechederra, M. Ujue Latasa

Publikováno v: Hepatology. 73:2380-2396

Background and aims Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81ae64ca991d1997b859d84eab9eef5
https://doi.org/10.1002/hep.31642

Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home

Autor: Javier Crespo, Lorena Cayon, Ana Álvarez-Cancelo, Víctor M. Martínez-Taboada, Emilio Fábrega, Tatiana Fernández-Lanas, Alvaro Santos-Laso, Paula Iruzubieta, Reinhard Wallmann, Jeffrey V. Lazarus, Joaquín Cabezas, Soraya Curiel-Olmo, Laura Rasines, Marcos López-Hoyos, José L. Hernández, Agustín García-Blanco

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Sci Rep . 2021 May 10;11(1):9819
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

The simplicity and low cost of rapid point-of-care tests greatly facilitate large-scale population testing, which can contribute to controlling the spread of the COVID-19 virus. We evaluated the applicability of a self-testing strategy for SARS-CoV2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d7fa7a3fa19107b34fb3f67dfbdfba
https://doaj.org/article/7b9e4027475d423480ce024e071262c0