Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Alvaro Rada-Iglesias"'
Autor:
Thais Ealo, Victor Sanchez-Gaya, Patricia Respuela, María Muñoz-San Martín, Elva Martin-Batista, Endika Haro, Alvaro Rada-Iglesias
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The specificity of gene expression during development requires the insulation of regulatory domains to avoid inappropriate enhancer-gene interactions. In vertebrates, this insulator function is mostly attributed to clusters of CTCF sites loc
Externí odkaz:
https://doaj.org/article/7c35716ba98249bc94a35aa49faec8e9
Autor:
Daniela Michelatti, Sven Beyes, Chiara Bernardis, Maria Luce Negri, Leonardo Morelli, Naiara Garcia Bediaga, Vittoria Poli, Luca Fagnocchi, Sara Lago, Sarah D’Annunzio, Nicole Cona, Ilaria Gaspardo, Aurora Bianchi, Jovana Jovetic, Matteo Gianesello, Alice Turdo, Caterina D’Accardo, Miriam Gaggianesi, Martina Dori, Mattia Forcato, Giuliano Crispatzu, Alvaro Rada-Iglesias, Maria Soledad Sosa, H. T. Marc Timmers, Silvio Bicciato, Matilde Todaro, Luca Tiberi, Alessio Zippo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Metastasis arises from disseminated tumour cells (DTCs) that are characterized by intrinsic phenotypic plasticity and the capability of seeding to secondary organs. DTCs can remain latent for years before giving rise to symptomatic overt met
Externí odkaz:
https://doaj.org/article/f053b57e57204e48bf78051e5364cb8f
Autor:
Ruiyuan Zheng, Kyle Moynahan, Theodoros Georgomanolis, Egor Pavlenko, Simon Geissen, Athanasia Mizi, Simon Grimm, Harshal Nemade, Rizwan Rehimi, Jil Bastigkeit, Jan-Wilm Lackmann, Matti Adam, Alvaro Rada-Iglesias, Peter Nuernberg, Anna Klinke, Simon Poepsel, Stephan Baldus, Argyris Papantonis, Yulia Kargapolova
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108898- (2024)
Summary: Myeloperoxidase (MPO) is an enzyme that functions in host defense. MPO is released into the vascular lumen by neutrophils during inflammation and may adhere and subsequently penetrate endothelial cells (ECs) coating vascular walls. We show t
Externí odkaz:
https://doaj.org/article/dfe17e008a34428ea148dfda83063921
Autor:
Sureshkumar Perumal Srinivasan, Harshal Nemade, Anna Cherianidou, Luying Peng, Sara Cruz-Molina, Alvaro Rada-Iglesias, Agapios Sachinidis
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Significant evidence points to Strip2 being a key regulator of the differentiation processes of pluripotent embryonic stem cells. However, Strip2 mediated epigenetic regulation of embryonic differentiation and development is quite unknown. H
Externí odkaz:
https://doaj.org/article/315833faca3e4cbe99743caac93a8564
Autor:
Nina Ishorst, Leonie Henschel, Frederic Thieme, Dmitriy Drichel, Sugirthan Sivalingam, Sarah L. Mehrem, Ariane C. Fechtner, Julia Fazaal, Julia Welzenbach, André Heimbach, Carlo Maj, Oleg Borisov, Jonas Hausen, Ruth Raff, Alexander Hoischen, Michael Dixon, Alvaro Rada‐Iglesias, Michaela Bartusel, Augusto Rojas‐Martinez, Khalid Aldhorae, Bert Braumann, Teresa Kruse, Christian Kirschneck, Gerrit Spanier, Heiko Reutter, Stefanie Nowak, Lina Gölz, Michael Knapp, Andreas Buness, Peter Krawitz, Markus M. Nöthen, Michael Nothnagel, Tim Becker, Kerstin U. Ludwig, Elisabeth Mangold
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Background Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome‐wide significant risk loci, which explain less than 40% of nsCL/P heritability
Externí odkaz:
https://doaj.org/article/205be1f83d914d678ac7257527a61a58
Autor:
Tomas Pachano, Alvaro Rada-Iglesias
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101492- (2022)
Summary: cis-regulatory elements (CREs) orchestrate the spatiotemporal control of gene expression. The regulatory activity of CREs is typically assessed by reporter assays, in which CREs are studied outside their endogenous context. To circumvent thi
Externí odkaz:
https://doaj.org/article/ec1d6decff0446118ae1952afbbd00fe
Autor:
Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao, Esther Mahabir, Hisham Bazzi, Alvaro Rada-Iglesias
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Poised enhancers (PEs) in embryonic stem cells have accessible chromatin, are bound by repressive Polycomb Group proteins, and interact with their targets prior to activation. However, whether this is recapitulated in vivo is unknown. Here the author
Externí odkaz:
https://doaj.org/article/63558f435dcb4a0498df455068ac08d2
Autor:
Yulia Kargapolova, Rizwan Rehimi, Hülya Kayserili, Joanna Brühl, Konstantinos Sofiadis, Anne Zirkel, Spiros Palikyras, Athanasia Mizi, Yun Li, Gökhan Yigit, Alexander Hoischen, Stefan Frank, Nicole Russ, Jonathan Trautwein, Bregje van Bon, Christian Gilissen, Magdalena Laugsch, Eduardo Gade Gusmao, Natasa Josipovic, Janine Altmüller, Peter Nürnberg, Gernot Längst, Frank J. Kaiser, Erwan Watrin, Han Brunner, Alvaro Rada-Iglesias, Leo Kurian, Bernd Wollnik, Karim Bouazoune, Argyris Papantonis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a cl
Externí odkaz:
https://doaj.org/article/3a21a85edc97413aa5f192b307a93267
Autor:
Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken, Hilde Van Esch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Circumferential skin creases (CSC-KT) is a rare polymalformative syndrome characterised by intellectual disability associated with skin creases on the limbs, and very characteristic craniofacial malformations. Previously, heterozygous and ho
Externí odkaz:
https://doaj.org/article/21a523c5582d4005ad24a2cf349d7f1b
Autor:
Julia Welzenbach, Nigel L. Hammond, Miloš Nikolić, Frederic Thieme, Nina Ishorst, Elizabeth J. Leslie, Seth M. Weinberg, Terri H. Beaty, Mary L. Marazita, Elisabeth Mangold, Michael Knapp, Justin Cotney, Alvaro Rada-Iglesias, Michael J. Dixon, Kerstin U. Ludwig
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100038- (2021)
Summary: Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common congenital facial malformation with a multifactorial etiology. Genome-wide association studies (GWASs) have identified multiple genetic risk loci. However, functional
Externí odkaz:
https://doaj.org/article/0c7e6a95d02a4a9283abd9285a586203