Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alvaro N. A. Monteiro"'
Autor:
Thales C. Nepomuceno, Ana P. P. dos Santos, Vanessa C. Fernandes, Anna B. R. Elias, Thiago T. Gomes, Guilherme Suarez-Kurtz, Edwin S. Iversen, Fergus J. Couch, Alvaro N. A. Monteiro, Marcelo A. Carvalho
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract BRCA1 (Breast Cancer 1, early onset) is linked to breast and ovarian cancer predisposition. Still, the risks conferred by a significant portion of BRCA1 variants identified in the population remains unknown. Most of these variants of uncerta
Externí odkaz:
https://doaj.org/article/decf3abb40d44c9c8d643204604e436b
Autor:
Edwin S. Iversen, Gary Lipton, Steven N. Hart, Kun Y. Lee, Chunling Hu, Eric C. Polley, Tina Pesaran, Amal Yussuf, Holly LaDuca, Elizabeth Chao, Rachid Karam, David E. Goldgar, Fergus J. Couch, Alvaro N. A. Monteiro
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Loss-of-function variants in the BRCA1 and BRCA2 susceptibility genes predispose carriers to breast and/or ovarian cancer. The use of germline testing panels containing these genes has grown dramatically, but the interpretation of the result
Externí odkaz:
https://doaj.org/article/a9b402e69faa4cd5a657f04f06fd7feb
Autor:
Sweta Dash, Sean Yoder, Tania Mesa, Andrew Smith, Ling Cen, Steven Eschrich, Guillermo N. Armaiz-Pena, Alvaro N. A. Monteiro
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Sustained adrenergic stimulation by norepinephrine (NE) contributes to ovarian carcinoma metastasis and impairment of chemotherapy response. Although the effect of sustained NE stimulation in cancer progression is well established, less is k
Externí odkaz:
https://doaj.org/article/c1562a4c5ba547debe29c88887771d9e
Autor:
Renata B. V. Abreu, Thiago T. Gomes, Thales C. Nepomuceno, Xueli Li, Mateus Fuchshuber-Moraes, Giuliana De Gregoriis, Guilherme Suarez-Kurtz, Alvaro N. A. Monteiro, Marcelo A. Carvalho
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast
Externí odkaz:
https://doaj.org/article/7d50829b184947b5905f3922f653d4a3
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-20 (2019)
Abstract Background The maintenance of genomic integrity is the responsibility of a complex network, denominated the DNA damage response (DDR), which controls the lesion detection and DNA repair. The main repair pathways are base excision repair (BER
Externí odkaz:
https://doaj.org/article/a8472e818f0c423b9bf1a640844a423a
Autor:
Michael J. Schell, Mingli Yang, Jamie K. Teer, Fang Yin Lo, Anup Madan, Domenico Coppola, Alvaro N. A. Monteiro, Michael V. Nebozhyn, Binglin Yue, Andrey Loboda, Gabriel A. Bien-Willner, Danielle M. Greenawalt, Timothy J. Yeatman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that
Externí odkaz:
https://doaj.org/article/33d97e94867e429f930222ed4bd1a79a
Autor:
Volha A. Golubeva, Thales C. Nepomuceno, Giuliana de Gregoriis, Rafael D. Mesquita, Xueli Li, Sweta Dash, Patrícia P. Garcez, Guilherme Suarez-Kurtz, Victoria Izumi, John Koomen, Marcelo A. Carvalho, Alvaro N. A. Monteiro
Publikováno v:
Cells, Vol 9, Iss 1, p 153 (2020)
The Zika virus (ZIKV) is a mosquito-borne Flavivirus and can be transmitted through an infected mosquito bite or through human-to-human interaction by sexual activity, blood transfusion, breastfeeding, or perinatal exposure. After the 2015−2016 out
Externí odkaz:
https://doaj.org/article/296546e851564ad08d8c7f2cd021f306
Publikováno v:
Cancers, Vol 11, Iss 4, p 522 (2019)
Genetic testing allows for the identification of germline DNA variations, which are associated with a significant increase in the risk of developing breast cancer (BC) and ovarian cancer (OC). Detection of a BRCA1 or BRCA2 pathogenic variant triggers
Externí odkaz:
https://doaj.org/article/d6e497e83b4d452bb8ae3a7ed06abfde
Supplementary Figure 1 from Structure-Based Assessment of Missense Mutations in Human BRCA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12852bc4970563754ff3625d6b03915c
https://doi.org/10.1158/0008-5472.22363521.v1
https://doi.org/10.1158/0008-5472.22363521.v1
Autor:
Renata B V, Abreu, Thiago T, Gomes, Thales C, Nepomuceno, Xueli, Li, Mateus, Fuchshuber-Moraes, Giuliana, De Gregoriis, Guilherme, Suarez-Kurtz, Alvaro N A, Monteiro, Marcelo A, Carvalho
Publikováno v:
Frontiers in pharmacology. 13
BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in