Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Alvaro Molina-Cruz"'
Autor:
Ines Martin-Martin, Bianca Burini Kojin, Azadeh Aryan, Adeline E. Williams, Alvaro Molina-Cruz, Paola Carolina Valenzuela-Leon, Gaurav Shrivastava, Karina Botello, Mahnaz Minai, Zach N. Adelman, Eric Calvo
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTMosquito saliva facilitates blood meal acquisition through pharmacologically active compounds that prevent host hemostasis and immune responses. Here, we generated two knockout (KO) mosquito lines by CRISPR/Cas9 to functionally characterize D
Externí odkaz:
https://doaj.org/article/3cccb39e9ce743b2811975d69e58eeef
Autor:
Thiago Luiz Alves e Silva, Gaspar E. Canepa, Brendan Sweeney, Patricia Hessab Alvarenga, Ming Zhao, Joel Vega-Rodríguez, Alvaro Molina-Cruz, Carolina Barillas-Mury
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT The mosquito immune system limits Plasmodium infection and malaria transmission. Plasmodium falciparum evades the mosquito defense response by expressing the surface protein P. falciparum P47 (Pfs47) that inhibits midgut epithelial nitration
Externí odkaz:
https://doaj.org/article/acb2ff8e37f34b22b18a8247e0f4331b
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010939 (2022)
Externí odkaz:
https://doaj.org/article/9bcae91a09d34bd88ebfce5de604f23b
Autor:
Alvaro Molina-Cruz, Nadia Raytselis, Roxanne Withers, Ankit Dwivedi, Peter D. Crompton, Boubacar Traore, Giovanna Carpi, Joana C. Silva, Carolina Barillas-Mury
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Molina-Cruz et al. analyzed 4,971 sequences of the Plasmodium falciparum Pfs47 gene and identified a combination of two SNP haplotypes highly correlated with geographic origin and transmission potential by mosquito vectors. A simple High-Resolution M
Externí odkaz:
https://doaj.org/article/fc42e52755fa4bd685f6c6320aeedb3b
Autor:
Bianca B. Kojin, Ines Martin-Martin, Helena R. C. Araújo, Brian Bonilla, Alvaro Molina-Cruz, Eric Calvo, Margareth L. Capurro, Zach N. Adelman
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-15 (2021)
Abstract Background The invasion of the mosquito salivary glands by Plasmodium sporozoites is a critical step that defines the success of malaria transmission and a detailed understanding of the molecules responsible for salivary gland invasion could
Externí odkaz:
https://doaj.org/article/86f778f4fc9c4099a700856a80cd99ff
Autor:
Lawrence T Wang, Lais S Pereira, Patience K Kiyuka, Arne Schön, Neville K Kisalu, Rachel Vistein, Marlon Dillon, Brian G Bonilla, Alvaro Molina-Cruz, Carolina Barillas-Mury, Joshua Tan, Azza H Idris, Joseph R Francica, Robert A Seder
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010133 (2021)
Combinations of monoclonal antibodies (mAbs) against different epitopes on the same antigen synergistically neutralize many viruses. However, there are limited studies assessing whether combining human mAbs against distinct regions of the Plasmodium
Externí odkaz:
https://doaj.org/article/d385b3ce72a7496ba9242f6f5b20828b
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Drug development efforts have focused mostly on the asexual blood stages of the malaria parasite Plasmodium falciparum. Except for primaquine, which has its own limitations, there are no available drugs that target the transmission of the pa
Externí odkaz:
https://doaj.org/article/89de155c15524a2398e01559fe8041c3
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 5, Pp 662-667 (2014)
Plasmodium falciparum originated in Africa, dispersed around the world as a result of human migration and had to adapt to several different indigenous anopheline mosquitoes. Anophelines from the New World are evolutionary distant form African ones an
Externí odkaz:
https://doaj.org/article/3c8f1d572dfe40d6a12ccadf578798b1
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168279 (2016)
Malaria is a life-threatening disease caused by Plasmodium falciparum parasites that is transmitted through the bites of infected anopheline mosquitoes. P. falciparum dispersal from Africa, as a result of human migration, required adaptation of the p
Externí odkaz:
https://doaj.org/article/b47e4ad2036343e6aeb0984a040c558b
Autor:
Alessandra S Orfano, Ana Paula M Duarte, Alvaro Molina-Cruz, Paulo F Pimenta, Carolina Barillas-Mury
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167178 (2016)
Malaria is endemic in the American continent and the Amazonian rainforest is the region with the highest risk of transmission. However, the lack of suitable experimental models to infect malaria vectors from the Americas has limited the progress to u
Externí odkaz:
https://doaj.org/article/310cbc101fb14288b0dbbecad6450d8f