Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alvaro Curiel-Garcia"'
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101899- (2022)
Summary: Orthotopic patient-derived xenograft models recapitulate the genomic complexity of the original tumor and some aspects of local microenvironment, useful for rapid development and validation of personalized treatment strategies. Here, we prec
Externí odkaz:
https://doaj.org/article/4820c73bad6d497cb562dbb9bc35ca66
Autor:
H. Carlo Maurer, Alvaro Curiel-Garcia, Sam Holmstrom, Pasquale Laise, Carmine F. Palermo, Steven A. Sastra, Anthony Andren, Zhang Li, Tessa LeLarge, Irina Sagalovskiy, Daniel R. Ross, Vilma Rosario, Kate Lu, Ethan Ferraiuolo, Nicholas Spinosa, Winston Wong, Kaitlin Shaw, John A. Chabot, Jeanine Genkinger, Hanina Hibshoosh, Gulam A. Manji, Alina Iuga, Roland M. Schmid, Michael A. Badgley, Kristen Johnson, Andrea Califano, Costas Lyssiotis, Kenneth P. Olive
Publikováno v:
bioRxiv
SummaryTo identify novel drivers of malignancy in pancreatic ductal adenocarcinoma (PDAC), we employed regulatory network analysis, which calculates the activity of transcription factors and other regulatory proteins based on the integrated expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09c8188e0f70d30874fd610f18de581
https://europepmc.org/articles/PMC10055246/
https://europepmc.org/articles/PMC10055246/
Autor:
Marie C. Hasselluhn, Amanda R. Decker-Farrell, Lukas Vlahos, Dafydd H. Thomas, Alvaro Curiel-Garcia, H. Carlo Maurer, Urszula N. Wasko, Lorenzo Tomassoni, Stephen A. Sastra, Carmine F. Palermo, Tanner C. Dalton, Alice Ma, Fangda Li, Ezequiel J. Tolosa, Hanina Hibshoosh, Martin E. Fernandez-Zapico, Alexander Muir, Andrea Califano, Kenneth P. Olive
The sparse vascularity of Pancreatic Ductal Adenocarcinoma (PDAC) presents a mystery: what prevents this aggressive malignancy from undergoing neoangiogenesis to counteract hypoxia and better support growth? An incidental finding from prior work on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f85a4a1495339be323481fceae5c3988
https://doi.org/10.1101/2023.03.02.529724
https://doi.org/10.1101/2023.03.02.529724
Autor:
Pasquale Laise, Mikko Turunen, Hans Carlo Maurer, Alvaro Curiel Garcia, Ela Elyada, Bernhard Schmierer, Lorenzo Tomassoni, Jeremy Worley, Mariano J. Alvarez, Jordan Kesner, Xiangtian Tan, Somnath Tagore, Ester Calvo Fernandez, Kelly Wong, Alexander L. E. Wang, Sabrina Ge, Alina C. Iuga, Aaron T. Griffin, Winston Wong, Gulam A. Manji, Faiyaz Notta, David A. Tuveson, Kenneth P. P. Olive, Andrea Califano
Publikováno v:
Cancer Research. 82:A007-A007
Despite extensive efforts, reproducible assessment of pancreatic ductal adenocarcinoma (PDA) heterogeneity and plasticity at the single cell level remains elusive. Systematic, network-based analysis of single cell RNA-seq profiles showed that most PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88290502e0c7c1f143c19aaa690efb76
https://doi.org/10.1158/1538-7445.panca22-a007
https://doi.org/10.1158/1538-7445.panca22-a007
Autor:
H. Carlo Maurer, Alvaro Curiel-Garcia, Pasquale Laise, Carmine F. Palermo, Stephen A. Sastra, Gulam A. Manji, Alina Iuga, Kristen Johnson, Jeanine Genkinger, Costas A. Lyssiotis, Andrea Califano, Kenneth P. Olive
Publikováno v:
Cancer Research. 82:B002-B002
We employed regulatory network analysis to identify master transcriptional regulators whose activity drives key pancreatic cancer phenotypes. Regulatory network analysis is a systems biology approach that computationally infers the activity of transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6131b19be408de905dcf579856111895
https://doi.org/10.1158/1538-7445.panca22-b002
https://doi.org/10.1158/1538-7445.panca22-b002
Autor:
Marie C. Hasselluhn, Lukas J. Vlahos, Dafydd Thomas, Alvaro Curiel Garcia, Amanda R. Decker, Tanner C. Dalton, Stephen A. Sastra, Carmine F. Palermo, Andrea Califano, Kenneth P. Olive
Publikováno v:
Cancer Research. 82:C032-C032
Immunotherapy has revolutionized clinical care for many cancers, yet these treatments fail to control disease in many patients and new strategies are needed to improve anti-tumor immunity and enhance response rates. There is great need for an increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4bc827156a15bb6aaa44b5c78f3dba7
https://doi.org/10.1158/1538-7445.panca22-c032
https://doi.org/10.1158/1538-7445.panca22-c032
Autor:
Alvaro Curiel-Garcia, Lorenzo Tomassoni, Lukas J. Vlahos, Carlo H. Maurer, Andrea Califano, Kenneth P. Olive
Publikováno v:
Cancer Research. 82:1902-1902
In recent years, rapidly decreasing sequencing costs have lead to an exponential growth in the availability of both bulk and single-cell transcriptomic data. Compilation of datasets generated from different research groups would allow for many additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57745252716a7f53bee9d90ba61208d
https://doi.org/10.1158/1538-7445.am2022-1902
https://doi.org/10.1158/1538-7445.am2022-1902
Autor:
Pasquale Laise, Mikko Turunen, Alvaro Curiel Garcia, Lorenzo Tomassoni, H. Carlo Maurer, Ela Elyada, Bernhard Schmierer, Jeremy Worley, Jordan Kesner, Xiangtian Tan, Ester Calvo Fernandez, Kelly Wong, Urszula N Wasko, Somnath Tagore, Alexander L. E. Wang, Sabrina Ge, Alina C. Iuga, Aaron Griffin, Winston Wong, Gulam A. Manji, Mariano J. Alvarez, Faiyaz Notta, David A. Tuveson, Kenneth P. Olive, Andrea Califano
Despite extensive efforts to characterize the transcriptional landscape of pancreatic ductal adenocarcinoma (PDA), reproducible assessment of subtypes with actionable dependencies remains challenging. Systematic, network-based analysis of regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3194d25904250470be5a50f1db45ef52
https://doi.org/10.1101/2020.10.27.357269
https://doi.org/10.1101/2020.10.27.357269
Autor:
Dafydd H. Thomas, Marie C. Hasselluhn, Alvaro Curiel Garcia, Amanda R. Decker, Kenneth P. Olive, Carlo Maurer
Publikováno v:
Cancer Research. 81:PR-014
Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by an extremely heterogeneous tumor microenvironment (TME) paired with a sparse and compromised vascular network. These features of the TME shape drug responses and contributes to PDAC’s dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38634df2c230436d1c9156d3f573eb13
https://doi.org/10.1158/1538-7445.panca21-pr-014
https://doi.org/10.1158/1538-7445.panca21-pr-014
Autor:
Kristen Johnson, Alvaro Curiel-Garcia, Kenneth P. Olive, Pasquale Laise, Gulam Abbas Manji, John A. Chabot, Andrea Califano, Irina Sagalovskiy, Carlo Maurer, Alina Iuga
Publikováno v:
Cancer Research. 81:PO-001
Large-scale sequencing studies have identified a limited number of genetic drivers of PDAC malignancy, with only four genes found mutated a high penetrance across human pancreatic tumors. This suggests that the cell-autonomous ability to progress, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c4bad055adabc052ea85e7647042c7
https://doi.org/10.1158/1538-7445.panca21-po-001
https://doi.org/10.1158/1538-7445.panca21-po-001