Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Alvaro Avivar‐Valderas"'
Autor:
Alvaro Avivar-Valderas, Cristina Martín-Martín, Cristina Ramírez, Borja Del Río, Ramón Menta, Pablo Mancheño-Corvo, Maitane Ortiz-Virumbrales, Ángel Herrero-Méndez, Julián Panés, Damián García-Olmo, José Luís Castañer, Itziar Palacios, Eleuterio Lombardo, Wilfried Dalemans, Olga DelaRosa
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), lack of HLA-II expression and low expression of co-stimulatory molecules such as CD40 and CD80. The lo
Externí odkaz:
https://doaj.org/article/da603270daf8404c98bf9261db4f3fa5
Autor:
Ulrike Begley, Maria Soledad Sosa, Alvaro Avivar‐Valderas, Ashish Patil, Lauren Endres, Yeriel Estrada, Clement T.Y. Chan, Dan Su, Peter C. Dedon, Julio A. Aguirre‐Ghiso, Thomas Begley
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 3, Pp 366-383 (2013)
Abstract Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progressi
Externí odkaz:
https://doaj.org/article/b4fd80b73e0a453d8400f3b919829c05
Autor:
Ryung S Kim, Alvaro Avivar-Valderas, Yeriel Estrada, Paloma Bragado, Maria Soledad Sosa, Julio A Aguirre-Ghiso, Jeffrey E Segall
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35569 (2012)
Breast cancers can recur after removal of the primary tumor and treatment to eliminate remaining tumor cells. Recurrence may occur after long periods of time during which there are no clinical symptoms. Tumor cell dormancy may explain these prolonged
Externí odkaz:
https://doaj.org/article/555d10035ba44e6ab945c53a0164d7fe
Autor:
Paloma Bragado, Yeriel Estrada, Maria Soledad Sosa, Alvaro Avivar-Valderas, David Cannan, Eric Genden, Marita Teng, Aparna C Ranganathan, Huei-Chi Wen, Avnish Kapoor, Emily Bernstein, Julio A Aguirre-Ghiso
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29974 (2012)
Head and neck squamous carcinoma (HNSCC) tumors carry dismal long-term prognosis and the role of tumor initiating cells (TICs) in this cancer is unclear. We investigated in HNSCC xenografts whether specific tumor subpopulations contributed to tumor g
Externí odkaz:
https://doaj.org/article/cb6b171e2de346b78980e2684f13b4ab
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
The PIK3CA gene, encoding the p110α catalytic unit of PI3Kα, is one of the most frequently mutated oncogenes in human cancer. Hence, PI3Kα is a target subject to intensive efforts in identifying inhibitors and evaluating their therapeutic potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282c99e85c18ba37f3ab7df829957e4b
https://doi.org/10.1158/1535-7163.c.6538756
https://doi.org/10.1158/1535-7163.c.6538756
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Timecourse of PI3K pathway inhibition in MCF7 cells illustrating pathway reactivation over time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00456e2abd72de83084efc8b4c7deb65
https://doi.org/10.1158/1535-7163.22507708
https://doi.org/10.1158/1535-7163.22507708
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Tumor cell line panel composition and growth inhibition sensitivity (GI50) to AZD8835.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4782fd316b02ec8951d691e4f7122f
https://doi.org/10.1158/1535-7163.22507675.v1
https://doi.org/10.1158/1535-7163.22507675.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Supp Fig 1 Tumour efficacy Supp Fig 2 In vitro gene expression modulation Supp Fig 3 In vivo biomarker analysis Supp Fig 4 HCC70 In vivo FDG uptake imaging Supp Fig 5 U87MG in vivo FDG uptake imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a49696169a1bdafab82b251d9a41f65
https://doi.org/10.1158/1535-7163.22505517.v1
https://doi.org/10.1158/1535-7163.22505517.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Loss of the tumor suppressor PTEN confers a tumor cell dependency on the PI3Kβ isoform. Achieving maximal inhibition of tumor growth through PI3K pathway inhibition requires sustained inhibition of PI3K signaling; however, efficacy is often limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3a8efc07d530f0362f410fd03bbc96
https://doi.org/10.1158/1535-7163.c.6538098.v1
https://doi.org/10.1158/1535-7163.c.6538098.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Teresa Klinowska, Marie Cumberbatch, Alvaro Avivar-Valderas, Radoslaw Polanski, Carol Lenaghan, Catherine Eberlein, Catherine Trigwell, Juliana Maynard, Oona Delpuech, Ursula Hancox, Urszula M. Polanska, James T. Lynch
Supplementary Table 1: Cell lines; Supplementary Table 2: Antibodies; Supplementary Table 3: Gene lists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91db55cea79f8877939d98d6dd7b2313
https://doi.org/10.1158/1535-7163.22505511
https://doi.org/10.1158/1535-7163.22505511