Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Alvaro A, Ordonez"'
Autor:
Leon L. Hsieh, Monika Looney, Alexis Figueroa, Guido Massaccesi, Georgia Stavrakis, Eduardo U. Anaya, Franco R. D'Alessio, Alvaro A. Ordonez, Andrew S. Pekosz, Victor R. DeFilippis, Petros C. Karakousis, Andrew H. Karaba, Andrea L. Cox
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The pathogenesis of COVID-19 is associated with a hyperinflammatory immune response. Monocytes and macrophages play a central role in this hyperinflammatory response to SARS-CoV-2. NLRP3 inflammasome activation has been observed in monocytes
Externí odkaz:
https://doaj.org/article/aa0e19b78c824561aa71c9c28ac4ee3b
Autor:
Alok K. Singh, Rulin Wang, Kara A. Lombardo, Monali Praharaj, C. Korin Bullen, Peter Um, Manish Gupta, Geetha Srikrishna, Stephanie Davis, Oliver Komm, Peter B. Illei, Alvaro A. Ordonez, Melissa Bahr, Joy Huang, Anuj Gupta, Kevin J. Psoter, Patrick S. Creisher, Maggie Li, Andrew Pekosz, Sabra L. Klein, Sanjay K. Jain, Trinity J. Bivalacqua, Srinivasan Yegnasubramanian, William R. Bishai
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107733- (2023)
Summary: Bacillus Calmette-Guérin (BCG) confers heterologous immune protection against viral infections and has been proposed as vaccine against SARS-CoV-2 (SCV2). Here, we tested intravenous BCG vaccination against COVID-19 using the golden Syrian
Externí odkaz:
https://doaj.org/article/9d718645d1e94cacb1bf9abf39d16432
Autor:
Filipa Mota, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Daniel P. Holt, Patricia De Jesus, Martin A. Lodge, Clara Erice, Xueyi Chen, Melissa Bahr, Kelly Flavahan, John Kim, Mary Katherine Brosnan, Alvaro A. Ordonez, Charles A. Peloquin, Robert F. Dannals, Sanjay K. Jain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the cent
Externí odkaz:
https://doaj.org/article/f0a782321c4e4e36aa37ab969660b2e2
Autor:
Stefanie Krug, Pankaj Prasad, Shiqi Xiao, Shichun Lun, Camilo A. Ruiz-Bedoya, Mariah Klunk, Alvaro A. Ordonez, Sanjay K. Jain, Geetha Srikrishna, Igor Kramnik, William R. Bishai
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Despite numerous advances in tuberculosis (TB) drug development, long treatment durations have led to the emergence of multidrug resistance, which poses a major hurdle to global TB control. Shortening treatment time therefore remains a top p
Externí odkaz:
https://doaj.org/article/9fc61409554c448b9963038eb9559826
Autor:
Alvaro A. Ordonez, C. Korin Bullen, Andres F. Villabona-Rueda, Elizabeth A. Thompson, Mitchell L. Turner, Vanessa F. Merino, Yu Yan, John Kim, Stephanie L. Davis, Oliver Komm, Jonathan D. Powell, Franco R. D’Alessio, Robert H. Yolken, Sanjay K. Jain, Lorraine Jones-Brando
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Sulforaphane, a chemical found in broccoli, has known antioxidant and antiinflammatory effects. Here, the authors show that it can inhibit SARS-CoV-2 and other coronavirus infections in mammalian cells and can decrease viral load in mice when treated
Externí odkaz:
https://doaj.org/article/a6ee1679bea84b2b98163a24fb77681b
Autor:
Brett M. Babin, Gabriela Fernandez-Cuervo, Jessica Sheng, Ori Green, Alvaro A. Ordonez, Mitchell L. Turner, Laura J. Keller, Sanjay K. Jain, Doron Shabat, Matthew Bogyo
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 803-814 (2021)
Externí odkaz:
https://doaj.org/article/a4f9610f36c44840bfaaf3df10a22e57
Autor:
Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Maria I. Reyes-Mantilla, Clara Erice, Melissa Bahr, Kelly Flavahan, Patricia de Jesus, John Kim, Catherine A. Foss, Charles A. Peloquin, Dima A. Hammoud, Alvaro A. Ordonez, Carlos A. Pardo, Sanjay K. Jain
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality. High-dose rifampin (35 mg/kg/d) is safe and improves the ba
Externí odkaz:
https://doaj.org/article/60a8e9fb510a41cda1c8b3797413d48b
Autor:
Alvaro A. Ordonez, Matthew F.L. Parker, Robert J. Miller, Donika Plyku, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Justin M. Luu, Dustin A. Dikeman, Wojciech G. Lesniak, Daniel P. Holt, Robert F. Dannals, Lloyd S. Miller, Steven P. Rowe, David M. Wilson, Sanjay K. Jain
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the
Externí odkaz:
https://doaj.org/article/5177739448e9442882f49a5d260f8ffe
Autor:
Oren Gordon, Mary Katherine Brosnan, Steve Yoon, Dawoon Jung, Kirsten Littlefield, Abhinaya Ganesan, Christopher A. Caputo, Maggie Li, William R. Morgenlander, Stephanie N. Henson, Alvaro A. Ordonez, Patricia De Jesus, Elizabeth W. Tucker, Nadine Peart Akindele, Zexu Ma, Jo Wilson, Camilo A. Ruiz-Bedoya, M. Elizabeth M. Younger, Evan M. Bloch, Shmuel Shoham, David Sullivan, Aaron A.R. Tobian, Kenneth R. Cooke, Ben Larman, Jogarao V.S. Gobburu, Arturo Casadevall, Andrew Pekosz, Howard M. Lederman, Sabra L. Klein, Sanjay K. Jain
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
BACKGROUND While most children who contract COVID-19 experience mild disease, high-risk children with underlying conditions may develop severe disease, requiring interventions. Kinetics of antibodies transferred via COVID-19 convalescent plasma early
Externí odkaz:
https://doaj.org/article/dd0c2a9ab4b14dc49bfbf39f9343ac3a
Autor:
Santosh Dhakal, Camilo A. Ruiz-Bedoya, Ruifeng Zhou, Patrick S. Creisher, Jason S. Villano, Kirsten Littlefield, Jennie Ruelas Castillo, Paula Marinho, Anne E. Jedlicka, Alvaro A. Ordonez, Melissa Bahr, Natalia Majewska, Michael J. Betenbaugh, Kelly Flavahan, Alice R. L. Mueller, Monika M. Looney, Darla Quijada, Filipa Mota, Sarah E. Beck, Jacqueline Brockhurst, Alicia M. Braxton, Natalie Castell, Mitchel Stover, Franco R. D’Alessio, Kelly A. Metcalf Pate, Petros C. Karakousis, Joseph L. Mankowski, Andrew Pekosz, Sanjay K. Jain, Sabra L. Klein
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT In the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in males than in females, including hospitalizations and deaths. Animal models
Externí odkaz:
https://doaj.org/article/c26a3303ffd040088f12495ee7b31392