Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Alvaro, Villarroel"'
Autor:
Maider Baltasar-Marchueta, Leire Llona, Sara M-Alicante, Iratxe Barbolla, Markel Garcia Ibarluzea, Rafael Ramis, Ane Miren Salomon, Brenda Fundora, Ariane Araujo, Arantza Muguruza-Montero, Eider Nuñez, Scarlett Pérez-Olea, Christian Villanueva, Aritz Leonardo, Sonia Arrasate, Nuria Sotomayor, Alvaro Villarroel, Aitor Bergara, Esther Lete, Humberto González-Díaz
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116602- (2024)
The development of new molecules for the treatment of calmodulin related cardiovascular or neurodegenerative diseases is an interesting goal. In this work, we introduce a novel strategy with four main steps: (1) chemical synthesis of target molecules
Externí odkaz:
https://doaj.org/article/f435f416ade94dcdb41b2eaf45510160
Publikováno v:
Bio-Protocol, Vol 14, Iss 7 (2024)
The assessment of peptide–protein interactions is a pivotal aspect of studying the functionality and mechanisms of various bioactive peptides. In this context, it is essential to employ methods that meet specific criteria, including sensitivity, bi
Externí odkaz:
https://doaj.org/article/2644bd726cdb4f0b920517658c97874b
Autor:
Alba Saez-Matia, Markel G. Ibarluzea, Sara M-Alicante, Arantza Muguruza-Montero, Eider Nuñez, Rafael Ramis, Oscar R. Ballesteros, Diego Lasa-Goicuria, Carmen Fons, Mónica Gallego, Oscar Casis, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2910 (2024)
Despite the increasing availability of genomic data and enhanced data analysis procedures, predicting the severity of associated diseases remains elusive in the absence of clinical descriptors. To address this challenge, we have focused on the KV7.2
Externí odkaz:
https://doaj.org/article/af67bcd6f0b14f7a82b9731ed560a5ae
Autor:
Eider Nuñez, Frederick Jones, Arantza Muguruza-Montero, Janire Urrutia, Alejandra Aguado, Covadonga Malo, Ganeko Bernardo-Seisdedos, Carmen Domene, Oscar Millet, Nikita Gamper, Alvaro Villarroel
Publikováno v:
eLife, Vol 12 (2023)
Neuronal KV7 channels, important regulators of cell excitability, are among the most sensitive proteins to reactive oxygen species. The S2S3 linker of the voltage sensor was reported as a site-mediating redox modulation of the channels. Recent struct
Externí odkaz:
https://doaj.org/article/0bd7d7f107f1445e8d187383cd53a107
Autor:
Janire Urrutia, Alejandra Aguado, Carolina Gomis-Perez, Arantza Muguruza-Montero, Oscar R. Ballesteros, Jiaren Zhang, Eider Nuñez, Covadonga Malo, Hee Jung Chung, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. Such consideratio
Externí odkaz:
https://doaj.org/article/06cb6d34b83948ddbd9c631e4790026c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during Alzheimer’s Disease (AD) due to the imbalance in the production vs. clearance. This accumulation of amyloid β deposits triggers microglial activation. Micro
Externí odkaz:
https://doaj.org/article/103bb225c1bf4fc4bbe806a00d7df262
Autor:
Alessandro Alaimo, Marco Lorenzoni, Paolo Ambrosino, Arianna Bertossi, Alessandra Bisio, Alice Macchia, Eugenio Zoni, Sacha Genovesi, Francesco Cambuli, Veronica Foletto, Dario De Felice, Maria Virginia Soldovieri, Ilaria Mosca, Francesco Gandolfi, Matteo Brunelli, Gianluca Petris, Anna Cereseto, Alvaro Villarroel, George Thalmann, Francesco Giuseppe Carbone, Marianna Kruithof-de Julio, Mattia Barbareschi, Alessandro Romanel, Maurizio Taglialatela, Andrea Lunardi
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-17 (2020)
Abstract Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer
Externí odkaz:
https://doaj.org/article/df6bf34ea7084a21b91211d2e2dccd09
Autor:
Eider Nuñez, Frederick Jones, Arantza Muguruza-Montero, Janire Urrutia, Alejandra Aguado, Covadonga Malo, Ganeko Bernardo-Seisdedos, Carmen Domene, Oscar Millet, Nikita Gamper, Alvaro Villarroel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06641bef8d53c31797dfb3c2a401dac
https://doi.org/10.7554/elife.81961.sa2
https://doi.org/10.7554/elife.81961.sa2
Autor:
Alba Saez-Matia, Arantza Muguruza-Montero, Sara M-Alicante, Eider Núñez, Rafael Ramis, Óscar R. Ballesteros, Markel G Ibarluzea, Carmen Fons, Aritz Leonardo, Aitor Bergara, Alvaro Villarroel
Advances in DNA sequencing technologies have revolutionized rare disease diagnosis, resulting in an increasing volume of available genomic data. Despite this wealth of information and improved procedures to combine data from various sources, identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da8a1b96ac9adf55689041e86e169cd9
https://doi.org/10.1101/2022.10.20.513007
https://doi.org/10.1101/2022.10.20.513007
Autor:
Pedro A. Lazo, Juan L. García, Paulino Gómez-Puertas, Íñigo Marcos-Alcalde, Cesar Arjona, Alvaro Villarroel, Rogelio González-Sarmiento, Carmen Fons
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4447 (2020)
Complex neurodevelopmental syndromes frequently have an unknown etiology, in which genetic factors play a pathogenic role. This study utilizes whole-exome sequencing (WES) to examine four members of a family with a son presenting, since birth, with e
Externí odkaz:
https://doaj.org/article/03fc879969354257aa2b9e14a8a6a498