Proteomic analysis of serum from a MeCP2 patient reveals an arginine biosynthesis pathway affected by the p.Lys254* variant.

Autor: Gong, Xiaoqin¹ (AUTHOR), Wang, Tuanmei¹ (AUTHOR), Chen, Anji¹ (AUTHOR), Ouyang, Geng¹ (AUTHOR), Lv, Mengmei¹ (AUTHOR), Gao, Jianxin¹ (AUTHOR), Yu, Baomei¹ (AUTHOR), Wu, Min¹ (AUTHOR), Qi, Huaxue¹ (AUTHOR), Zhu, Yunsu¹ (AUTHOR), Dai, Jinjin¹ (AUTHOR), He, Jun¹ (AUTHOR), Liu, Jiyang² (AUTHOR) 41002978@qq.com, Peng, Xiangwen¹ (AUTHOR) pxw1237@163.com

Publikováno v: Clinical Case Reports. Dec2024, Vol. 12 Issue 12, p1-9. 9p.

Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.

Autor: Alvarez-Saavedra M; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile., Yan K; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., De Repentigny Y; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Hashem LE; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Chaudary N; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Sarwar S; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Yang D; Departments of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada., Ioshikhes I; Departments of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada., Kothary R; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; Departments of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Hirayama T; KOKORO-Biology Group, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.; Department of Anatomy and Developmental Neurobiology, Tokushima University Graduate School of Medical Sciences, Tokushima, Japan., Yagi T; KOKORO-Biology Group, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan., Picketts DJ; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.; Departments of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2019 Oct 17; Vol. 12, pp. 243. Date of Electronic Publication: 2019 Oct 17 (Print Publication: 2019).

Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.

Autor: Alvarez-Saavedra M; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, ON K1N 6N5, Canada; Center for Biomedical Research, Faculty of Biological Sciences, Universidad Andres Bello, Avenida República 239, Santiago, Chile. Electronic address: matias.alvarez-saavedra@nyumc.org., De Repentigny Y; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada., Yang D; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, ON K1N 6N5, Canada; Ottawa Institute of Systems Biology (OISB), University of Ottawa, ON K1N 6N5, Canada., O'Meara RW; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, ON K1N 6N5, Canada., Yan K; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada., Hashem LE; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, ON K1N 6N5, Canada., Racacho L; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, ON K1N 6N5, Canada; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1N 6N5, Canada., Ioshikhes I; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, ON K1N 6N5, Canada; Ottawa Institute of Systems Biology (OISB), University of Ottawa, ON K1N 6N5, Canada., Bulman DE; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1N 6N5, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Parks RJ; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, ON K1N 6N5, Canada., Kothary R; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, ON K1N 6N5, Canada., Picketts DJ; Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L1, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, ON K1N 6N5, Canada; Department of Biochemistry, Microbiology & Immunology, University of Ottawa, ON K1N 6N5, Canada. Electronic address: dpicketts@ohri.ca.

Publikováno v: Cell reports [Cell Rep] 2016 Oct 11; Vol. 17 (3), pp. 862-875.

When Dad's Stress Gets under Kid's Skin—Impacts of Stress on Germline Cargo and Embryonic Development.

Autor: Kretschmer, Miriam^1,2 (AUTHOR) miriam.kretschmer@hest.ethz.ch, Fischer, Vincent^1,2 (AUTHOR) vincent.fischer@hest.ethz.ch, Gapp, Katharina^1,2 (AUTHOR) katharina.gapp@hest.ethz.ch

Publikováno v: Biomolecules (2218-273X). Dec2023, Vol. 13 Issue 12, p1750. 30p.

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.

Autor: Alvarez-Saavedra M; 1] Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 [2] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., De Repentigny Y; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6., Lagali PS; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6., Raghu Ram EV; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel., Yan K; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6., Hashem E; 1] Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 [2] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Ivanochko D; 1] Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 [2] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Huh MS; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6., Yang D; 1] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5 [2] Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Mears AJ; Vision Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6., Todd MA; 1] Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 [2] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Corcoran CP; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6., Bassett EA; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Tokarew NJ; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Kokavec J; Institute of Pathologic Physiology, First Faculty of Medicine, Charles University in Prague, Prague 12853, Czech Republic., Majumder R; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA., Ioshikhes I; 1] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5 [2] Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Wallace VA; 1] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5 [2] Vision Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6., Kothary R; 1] Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 [2] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5., Meshorer E; Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel., Stopka T; Institute of Pathologic Physiology, First Faculty of Medicine, Charles University in Prague, Prague 12853, Czech Republic., Skoultchi AI; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA., Picketts DJ; 1] Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 [2] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5 [3] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5.

Publikováno v: Nature communications [Nat Commun] 2014 Jun 20; Vol. 5, pp. 4181. Date of Electronic Publication: 2014 Jun 20.