Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains.

Autor: Millan DS; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Kayser-Bricker KJ; FORMA Therapeutics Inc., 35 Northeast Industrial Road, Branford, Connecticut 06405, United States., Martin MW; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Talbot AC; FORMA Therapeutics Inc., 35 Northeast Industrial Road, Branford, Connecticut 06405, United States., Schiller SER; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Herbertz T; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Williams GL; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Luke GP; FORMA Therapeutics Inc., 35 Northeast Industrial Road, Branford, Connecticut 06405, United States., Hubbs S; FORMA Therapeutics Inc., 35 Northeast Industrial Road, Branford, Connecticut 06405, United States., Alvarez Morales MA; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Cardillo D; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Troccolo P; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., Mendes RL; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States., McKinnon C; FORMA Therapeutics Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Jul 14; Vol. 8 (8), pp. 847-852. Date of Electronic Publication: 2017 Jul 14 (Print Publication: 2017).