Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Alvar D. Gossert"'
Autor:
Sebastian A. G. Braus, Francesca L. Short, Stefanie Holz, Matthew J. M. Stedman, Alvar D. Gossert, Manuela K. Hospenthal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Many bacteria can take up exogenous DNA, in a process that often requires surface appendages composed of thousands of protein subunits called pilins. Here, Braus et al. show that a minor pilin binds directly to DNA and is important for DNA uptake in
Externí odkaz:
https://doaj.org/article/8f792d27c6b04ba7ba2fe5bb3559af14
Autor:
Philip Rößler, Daniel Mayer, Ching-Ju Tsai, Dmitry B. Veprintsev, Gebhard F. X. Schertler, Alvar D. Gossert
Publikováno v:
Molecules, Vol 25, Iss 24, p 5984 (2020)
In this work, we examine methyl nuclear magnetic resonance (NMR) spectra of the methionine ε-[13CH3] labelled thermostabilized β1 adrenergic receptor from turkey in association with a variety of different effectors, including mini-Gs and nanobody 6
Externí odkaz:
https://doaj.org/article/96d2b623dd234e1ba8de5ea56ecfc1d0
Autor:
Giacomo Padroni, Maria Bikaki, Mihajlo Novakovic, Antje C. Wolter, Simon H. Rüdisser, Alvar D. Gossert, Alexander Leitner, Frederic H.-T Allain
Publikováno v:
Nucleic Acids Research, 51 (9)
The pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA recognition and druggabilit
Publikováno v:
Biophys J
The conserved fold of thioredoxin (Trx)-like thiol/disulfide oxidoreductases contains an invariant cis-proline residue (P76 in Escherichia coli Trx) that is essential for Trx function and that is responsible for the folding rate-limiting step. E. col
Autor:
Johanna M Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Externí odkaz:
https://doaj.org/article/935bc8e9e098406ea024047d133a1803
Autor:
Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C. Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I. Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M. Carroll, Pablo Sánchez, Ahmed A. Zayed, Dylan R. Cronin, Silvia G. Acinas, Peer Bork, Chris Bowler, Tom O. Delmont, Josep M. Gasol, Alvar D. Gossert, André Kahles, Matthew B. Sullivan, Patrick Wincker, Georg Zeller, Serina L. Robinson, Jörn Piel, Shinichi Sunagawa
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature, 607(7917), 111-118
Nature
Nature, 607 (7917)
Nature 607 (2022) 7917
instname
Nature, 607(7917), 111-118
Nature
Nature, 607 (7917)
Nature 607 (2022) 7917
8 pages, 4 figures, supplementary information https://doi.org/10.1038/s41586-022-04862-3.-- This Article is contribution number 130 of Tara Oceans
Natural microbial communities are phylogenetically and metabolically diverse. In addition to under
Natural microbial communities are phylogenetically and metabolically diverse. In addition to under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f2f4533523bcd8b38d773d04f8c87b
http://hdl.handle.net/10261/278488
http://hdl.handle.net/10261/278488
Autor:
Francesca L. Short, Sebastian A.G. Braus, Alvar D. Gossert, Stefanie Holz, Manuela K. Hospenthal, Matthew J.M. Stedman
Publikováno v:
Nature Communications, 13 (1)
Naturally competent bacteria encode sophisticated protein machinery for the uptake and translocation of exogenous DNA into the cell. If this DNA is integrated into the bacterial genome, the bacterium is said to be naturally transformed. Most competen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de94d2e204365f58d1e3cca5f9feb63
Publikováno v:
Angewandte Chemie. 132:19492-19501
Autor:
Anna Vulpetti, Andrew Proudfoot, Andreas Lingel, Christelle Henry, Andreas O. Frank, Regis Denay, Tony Reinsperger, Alexandra Frommlet, Ulrich Hommel, Burkhard Luy, Alvar D. Gossert
Publikováno v:
Angewandte Chemie International Edition. 59:14809-14817
Fragment-based lead discovery has become a fundamental approach to identify ligands that efficiently interact with disease-relevant targets. Among the numerous screening techniques, fluorine-detected NMR has gained popularity owing to its high sensit
Publikováno v:
Journal of Biomolecular NMR. 74:579-594
Fluorine NMR has recently gained high popularity in drug discovery as it allows efficient and sensitive screening of large numbers of ligands. However, the positive hits found in screening must subsequently be ranked according to their affinity in or