Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation

Autor: Raghu Ram Edupuganti, Arigela Harikumar, Yair Aaronson, Alva Biran, Badi Sri Sailaja, Malka Nissim-Rafinia, Gajendra Kumar Azad, Malkiel A. Cohen, Jung Eun Park, Chikdu S. Shivalila, Styliani Markoulaki, Siu Kwan Sze, Rudolf Jaenisch, Eran Meshorer

Publikováno v: Stem Cell Reports, Vol 9, Iss 4, Pp 1291-1303 (2017)

Embryonic stem cells (ESCs) are regulated by pluripotency-related transcription factors in concert with chromatin regulators. To identify additional stem cell regulators, we screened a library of endogenously labeled fluorescent fusion proteins in mo

Externí odkaz: https://doaj.org/article/5f66f7eff23844399afd3f9b383f2320

CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands

Autor: Clément Rouillon, Bruna V Eckhardt, Leonie Kollenstart, Fabian Gruss, Alexander E E Verkennis, Inge Rondeel, Peter H L Krijger, Giulia Ricci, Alva Biran, Theo van Laar, Charlotte M Delvaux de Fenffe, Georgiana Luppens, Pascal Albanese, Koichi Sato, Richard A Scheltema, Wouter de Laat, Puck Knipscheer, Nynke H Dekker, Anja Groth, Francesca Mattiroli

Publikováno v: Nucleic acids research, 51(8)

During every cell cycle, both the genome and the associated chromatin must be accurately replicated. Chromatin Assembly Factor-1 (CAF-1) is a key regulator of chromatin replication, but how CAF-1 functions in relation to the DNA replication machinery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1705dce99317902bb4251515f272380
https://doi.org/10.1093/nar/gkad171

Chromatin plasticity in pluripotent and cancer stem cells

Autor: Alva Biran, Eran Meshorer

Publikováno v: Stem Cell Epigenetics ISBN: 9780128140857

Epigenetic mechanisms, including posttranslational modifications of histones and methylation of DNA, control gene expression patterns in development and disease. Characteristically, embryonic stem cells (ESCs) have a unique “open” and hyperdynami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f7c6d2541b09d26285ba14dd8848784
https://doi.org/10.1016/b978-0-12-814085-7.00009-x

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

Autor: Eran Meshorer, Badi Sri Sailaja, Gajendra Kumar Azad, Alva Biran, David T. Brown, Takumi Takizawa, Malka Nissim-Rafinia, Kenji Ito, Yasuhiro Yamada

Publikováno v: The Journal of Cell Biology

Neuronal stimulation leads to the expression of immediate early genes (IEGs). Azad et al. show that neuronal depolarization induces replacement of the linker histone H1 by PARP1 at IEG promoters in a manner that requires H1 phosphorylation and H1 pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b70d7479c58fc32aba476ec4ef99e31

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation

Autor: Styliani Markoulaki, Raghu Ram Edupuganti, Siu Kwan Sze, Gajendra Kumar Azad, Arigela Harikumar, Malkiel A. Cohen, Jung Eun Park, Yair Aaronson, Alva Biran, Malka Nissim-Rafinia, Eran Meshorer, Rudolf Jaenisch, Chikdu S. Shivalila, Badi Sri Sailaja

Publikováno v: Stem Cell Reports
Elsevier
Stem Cell Reports, Vol 9, Iss 4, Pp 1291-1303 (2017)
Stem Cell Reports, 9, 4, pp. 1291-1303
Stem Cell Reports, 9, 1291-1303

Embryonic stem cells (ESCs) are regulated by pluripotency-related transcription factors in concert with chromatin regulators. To identify additional stem cell regulators, we screened a library of endogenously labeled fluorescent fusion proteins in mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aeb47533a8bc99132431157745017a7
https://pubmed.ncbi.nlm.nih.gov/28966118