Zobrazeno 1 - 10
of 816
pro vyhledávání: '"Alun D. Hughes"'
Autor:
Constantin-Cristian Topriceanu, Mit Shah, Matthew Webber, Fiona Chan, Hunain Shiwani, Marcus Richards, Jonathan Schott, Nishi Chaturvedi, James C. Moon, Alun D. Hughes, Aroon D. Hingorani, Declan P. O’Regan, Gabriella Captur
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Although APOE ε4 allele carriage confers a risk for coronary artery disease, its persistence in humans might be explained by certain survival advantages (antagonistic pleiotropy). Methods Combining data from ~ 37,000 persons from
Externí odkaz:
https://doaj.org/article/11cdd86813114bbcb62a5c1ef1c08698
Autor:
Rayan Anbar, Siana Jones, Nish Chaturvedi, Carole Sudre, Marcus Richards, Salahaden R. Sultan, Alun D. Hughes
Publikováno v:
Atherosclerosis Plus, Vol 55, Iss , Pp 39-46 (2024)
Background: Cognitive function has an important role in determining the quality of life of older adults. Cardiovascular disease (CVD) is common in older people and may compromise cognitive performance; however, the extent to which this is related to
Externí odkaz:
https://doaj.org/article/7578fadabd074f959903c85c39333b58
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
BackgroundNear-infrared spectroscopy (NIRS) provides a non-invasive, cost-effective method for assessing skeletal muscle oxidative capacity when combined with a short exercise protocol and arterial occlusions. However, the impact of different exercis
Externí odkaz:
https://doaj.org/article/726851b1137c474d85f52296b03d34a9
Autor:
Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M. Brown, Gabriella Captur, Molly R.E.Cartlidge, David M. Cash, William Coath, Daniel Davis, John C. Dickson, James Groves, Alun D. Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E. Keuss, Josh King-Robson, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Alicja Rapala, Catherine J. Scott, Rebecca Street, Carole H. Sudre, David L. Thomas, Andrew Wong, Selina Wray, Henrik Zetterberg, Nishi Chaturvedi, Nick C. Fox, Sebastian J. Crutch, Marcus Richards, Jonathan M. Schott
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-21 (2024)
Abstract Background Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person’s risk for cognitive decline later in life. Furthermore, the pathological
Externí odkaz:
https://doaj.org/article/9fdd7c07f6e74bf4bc709c0fc60fb7cd
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)
Background Observational epidemiological studies have reported an association between childhood adiposity and altered cardiac morphology and function in later life. However, whether this is due to a direct consequence of being overweight during child
Externí odkaz:
https://doaj.org/article/7eb5f434dfea4d92a2430f011eea098d
Autor:
Michele Orini, Stefan van Duijvenboden, William J. Young, Julia Ramírez, Aled R. Jones, Alun D. Hughes, Andrew Tinker, Patricia B. Munroe, Pier D. Lambiase
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Heart rate variability (HRV) is a cardiac autonomic marker with predictive value in cardiac patients. Ultra-short HRV (usHRV) can be measured at scale using standard and wearable ECGs, but its association with cardiovascular events in the ge
Externí odkaz:
https://doaj.org/article/0eb58ed853194b709444e4763ef33c0f
Autor:
Constantin-Cristian Topriceanu, Eesha Dev, Mahmood Ahmad, Rebecca Hughes, Hunain Shiwani, Matthew Webber, Kenan Direk, Andrew Wong, Martin Ugander, James C. Moon, Alun D. Hughes, Jane Maddock, Todd T. Schlegel, Gabriella Captur
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background DNA methylation (DNAm) age acceleration (AgeAccel) and cardiac age by 12-lead advanced electrocardiography (A-ECG) are promising biomarkers of biological and cardiac aging, respectively. We aimed to explore the relationships betwe
Externí odkaz:
https://doaj.org/article/e91430dc36f344b3b9b0d182e9b29e69
Mechanisms underlying exercise intolerance in long COVID: An accumulation of multisystem dysfunction
Autor:
Alexandra Jamieson, Lamia Al Saikhan, Lamis Alghamdi, Lee Hamill Howes, Helen Purcell, Toby Hillman, Melissa Heightman, Thomas Treibel, Michele Orini, Robert Bell, Marie Scully, Mark Hamer, Nishi Chaturvedi, Hugh Montgomery, Alun D. Hughes, Ronan Astin, Siana Jones
Publikováno v:
Physiological Reports, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS‐CoV‐2 virus (“long COVID”) is not fully understood. Cases were recruited from a long COVID clinic (N = 32; 44 ± 12 years; 10
Externí odkaz:
https://doaj.org/article/8a78c62cb1444380a86a417e704a4ff0
Autor:
Constantin-Cristian Topriceanu, Massimiliano Fornasiero, Han Seo, Matthew Webber, Kathryn E. Keenan, Karl F. Stupic, Rüdiger Bruehl, Bernd Ittermann, Kirsty Price, Louise McGrath, Wenjie Pang, Alun D. Hughes, Reza Nezafat, Peter Kellman, Iain Pierce, James C. Moon, Gabriella Captur
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Introduction A long T2 relaxation time can reflect oedema, and myocardial inflammation when combined with increased plasma troponin levels. Cardiovascular magnetic resonance (CMR) T2 mapping therefore has potential to provide a key diagnosti
Externí odkaz:
https://doaj.org/article/caef70cde30d4ae6831d1421826c142d
Autor:
Amand F. Schmidt, Roshni Joshi, Maria Gordillo-Marañón, Fotios Drenos, Pimphen Charoen, Claudia Giambartolomei, Joshua C. Bis, Tom R. Gaunt, Alun D. Hughes, Deborah A. Lawlor, Andrew Wong, Jackie F. Price, Nishi Chaturvedi, Goya Wannamethee, Nora Franceschini, Mika Kivimaki, Aroon D. Hingorani, Chris Finan
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-10 (2023)
Schmidt et al. evaluate the effects of elevated circulating concentrations of cholesterol-containing lipoproteins and apolipoproteins. Effects are seen on measures of atherosclerosis, blood pressure, c-reactive protein, coronary heart disease, heart
Externí odkaz:
https://doaj.org/article/a4840a392ca142fd8b56739e6ab3255e