Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alun D McCarthy"'
Autor:
Alun D. McCarthy, Ian J. Owens, Stephanie M. McTighe, Timothy J. Bussey, Lisa M. Saksida, Aruna T. Bansal
Publikováno v:
Pharmacology Biochemistry and Behavior. 98:76-80
FK962 is a member of a novel class of compounds that promote somatostatin production in the brain, and is being developed as a treatment for patients with Alzheimer's disease. As acetylcholinesterase inhibitors such as Aricept© (donepezil) are widel
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 360:1579-1588
Over the last two decades, identification of polymorphisms that influence human diseases has begun to have an impact on the provision of medical care. The promise of genetics lies in its ability to provide insights into an individual's susceptibility
Autor:
Alun D. McCarthy
Publikováno v:
Current Pharmacogenomics. 1:187-191
Autor:
Daniele Andreotti, Nigel S. Watson, Meenu Sareen, Chuen Chan, Jan Josef Scicinski, Alun D McCarthy, Panayiotis Alexandrou Procopiou, Brian Dymock, B.C. Ross, Michael A. Snowden, Keeling Suzanne Elaine, Julie L. Hutson, Brian Cox, Peter J Sharratt
Publikováno v:
Journal of Medicinal Chemistry. 39:207-216
Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-4 were prepared and evaluated for their ability to inhibit rat liver microsomal squalene synthase (SQS) in vitro. These modifications were well tolerated for com
Autor:
Alun D McCarthy, Gustav Dallner, Julie L. Hutson, Johan Ericsson, Elisabeth Peterson, Anders Thelin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1215:245-249
The effects of squalestatin 1 on rat brain and liver homogenates and on Chinese hamster ovary tissue culture cells have been investigated. This compound effectively inhibits squalene biosynthesis in a highly selective manner. Cytoplasmic farnesyl pyr
Publikováno v:
ResearcherID
Current Protocols in Protein Science
Scopus-Elsevier
Current Protocols in Protein Science
Scopus-Elsevier
Two alternative procedures are described for the purification of the major form of glutamate dehydrogenase (L-glutamate-NAD(P)+ oxidoreductase (deaminating), EC 1.4.1.3: GDH) from ox liver and brain. The first involves affinity chromatography on a co
Publikováno v:
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
The efforts over the last 20 years to identify polymorphisms that influence human diseases are beginning to have a clear impact on medical care. The promise of the “new genetics” lies in its ability to provide information on an individual's susce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed924045a7c7d96f00cb3e2a4e568a3c
https://doi.org/10.1002/047001153x.g206211
https://doi.org/10.1002/047001153x.g206211
Autor:
Barrie E. Kirk, Meenu Sareen, Panayiotis A. Procopiou, Alun D McCarthy, Michael A. Snowden, Stephen J. Spooner, Peter J Sharratt, Julia Widdowson, Brian Cox, Nigel S. Watson, Michael George Lester
Publikováno v:
Journal of medicinal chemistry. 39(7)
Squalestatin analogues modified at C3 were prepared and evaluated for their ability to inhibit rat liver microsomal squalene synthase in vitro. While the 4,6-dimethyloctenoate ester group at C6 was maintained, a number of modifications to the C3 carb
Autor:
A. M. Pastorino, Ulisse Garbin, Vincenzo Lo Cascio, Alun D McCarthy, Anna Davoli, Luciano Cominacini, M. Campagnola, Alice De Santis
Lipid hydroperoxides have been implicated in the pathogenesis of atherosclerosis. This work was therefore set up to obtain a fast and specific chemiluminescent assay for measuring hydroperoxides in native low-density lipoprotein (LDL). The apparatus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156e25b9b9d0e9586d8b11793802e99e
http://hdl.handle.net/11562/3098
http://hdl.handle.net/11562/3098
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences; Aug2005, Vol. 360 Issue 1460, p1579-1588, 10p