Zobrazeno 1 - 10
of 449
pro vyhledávání: '"Alton Meister"'
Autor:
Alton Meister
Publikováno v:
Nutrition Reviews. 42:397-410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17204acbfba09d6ac81f736bf9440b0a
https://doi.org/10.1111/j.1753-4887.1984.tb02277.x
https://doi.org/10.1111/j.1753-4887.1984.tb02277.x
Autor:
Alton Meister
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1271:35-42
Glutathione deficiency produced by giving buthionine sulfoximine (an inhibitor of gamma-glutamylcysteine synthetase) to animals, leads to biphasic decline in cellular glutathione levels associated with sequestration of glutathione in mitochondria. Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccf4aac7cf117a1ed32c88393013f3d
https://doi.org/10.1016/0925-4439(95)00007-q
https://doi.org/10.1016/0925-4439(95)00007-q
Publikováno v:
Journal of Biological Chemistry. 270:12471-12475
Mutant human γ-glutamyl transpeptidases with amino acid substitutions on the light subunit at the Asp residues conserved among several species, and at the unique cysteine residue (Cys-454), were prepared and expressed in a baculovirus insect cell sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88c254b9c8462e6c01de9b1207b7b525
https://doi.org/10.1074/jbc.270.21.12471
https://doi.org/10.1074/jbc.270.21.12471
Autor:
Terry K. Smith, Alton Meister
Publikováno v:
Journal of Biological Chemistry. 270:12476-12480
γ-Glutamyl transpeptidase, an enzyme of central significance in glutathione metabolism, is inactivated by iodoacetamide, which esterifies an active site carboxyl group identified here as that of Asp-422. Treatment of the inactivated enzyme with hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f48fb952eab354527195d294cfbc02ea
https://doi.org/10.1074/jbc.270.21.12476
https://doi.org/10.1074/jbc.270.21.12476
Publikováno v:
Proceedings of the National Academy of Sciences. 92:2360-2364
Acivicin is a potent inhibitor of gamma-glutamyl transpeptidase (EC 2.3.2.2), an enzyme of importance in glutathione metabolism. Acivicin inhibition and binding are prevented by gamma-glutamyl substrates and analogs (e.g., serine plus borate), consis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097d028336155b5a6467845cd9cea1b7
https://doi.org/10.1073/pnas.92.6.2360
https://doi.org/10.1073/pnas.92.6.2360
Publikováno v:
Proceedings of the National Academy of Sciences. 92:1232-1236
Glutathione (GSH) synthetase [gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming), EC 6.3.2.3], an enzyme present in almost all cells, catalyzes the ATP-dependent synthesis of GSH from gamma-L-glutamyl-L-cysteine and glycine. Highly purified pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef689c10b1048272c7fc9eae3cef742
https://doi.org/10.1073/pnas.92.4.1232
https://doi.org/10.1073/pnas.92.4.1232
Publikováno v:
Proceedings of the National Academy of Sciences. 92:126-130
A mutant of human gamma-glutamyl transpeptidase (EC 2.3.2.2, a membrane-bound enzyme of importance in glutathione metabolism) that differs from the wild type by deletion of the putative signal peptide/anchor domain (amino acid residues 1-27) was expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a255605992d75b1ef85d3e49fa973b
https://doi.org/10.1073/pnas.92.1.126
https://doi.org/10.1073/pnas.92.1.126
Publikováno v:
Journal of Biological Chemistry. 269:21435-21439
Inactivation of gamma-glutamyl transpeptidase by acivicin (L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazole acetic acid) is rapid, thought to be irreversible, and associated with binding of close to 1 mol of inhibitor/mol of enzyme. Previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed88f580070efda938ee64681c8cce3a
https://doi.org/10.1016/s0021-9258(17)31822-7
https://doi.org/10.1016/s0021-9258(17)31822-7
Autor:
Alton Meister
Publikováno v:
Journal of Biological Chemistry. 269:9397-9400
strong evolutionary link between GSH and eukaryotic aerobic metabolism that is reflected in the function of GSH in protection against oxygen toxicity (2). GSH is not required in the diet of animals but is synthesized in virtually all animal cells' by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bb10df4141cc4575dde3f52c474bff
https://doi.org/10.1016/s0021-9258(17)36891-6
https://doi.org/10.1016/s0021-9258(17)36891-6
Publikováno v:
Circulation Research. 74:115-120
Results from in vitro experiments suggest that development of nitrate tolerance is due to a depletion of vascular thiol compounds (ie, cysteine and glutathione [GSH]) necessary for the bioconversion of organic nitrates. However, it is unknown whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe95346ed60ce87d95479bcd51206e76
https://doi.org/10.1161/01.res.74.1.115
https://doi.org/10.1161/01.res.74.1.115