Výsledky vyhledávání - "Alton, Eric WFW"

Akademický článek

Taking stock of gene therapy for cystic fibrosis

Autor: Alton Eric WFW, Geddes Duncan M, Stern Myra

Publikováno v: Respiratory Research, Vol 1, Iss 2, Pp 78-81 (2000)

Abstract The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal models in vivo has been followed by numerous clinical studies using both viral a

Externí odkaz: https://doaj.org/article/1a6a17371af74077a190be3620c8bd0c

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Periodical

Fixing lung health in the UK: accelerating respiratory research and innovation

Autor: Routley, Cheryl, Walker, Samantha, Alton, Eric WFW, Hall, Ian P

Publikováno v: Thorax; 2024, Vol. 79 Issue: 9 p809-810, 2p

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Akademický článek

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo

Publikováno v: Respiratory Research, Vol 7, Iss 1, p 26 (2006)

Abstract Background The cationic lipid Genzyme lipid (GL) 67 is the current "gold-standard" for in vivo lung gene transfer. Here, we assessed, if GL67 mediated uptake of siRNAs and asODNs into airway epithelium in vivo. Methods Anti-lacZ and ENaC (ep

Externí odkaz: https://doaj.org/article/04dfa5f2f34d4da1891b04915a9fe79f

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Akademický článek

Prospects for gene therapy in lung disease

Autor: Davies, Jane C, Geddes, Duncan M, Alton, Eric WFW

Publikováno v: In Current Opinion in Pharmacology 2001 1(3):272-278

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Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Publikováno v: Alton, E WFW, Beekman, J M, Boyd, A C, Brand, J, Carlon, M S, Connolly, M M, Chan, M, Conlon, S, Davidson, H, Davies, J C, Davies, L A, Dekkers, J F, Doherty, A, Gea-sorli, S, Gill, D R, Griesenbach, U, Hasegawa, M, Higgins, T E, Hironaka, T, Hyndman, L, McLachlan, G, Inoue, M, Hyde, S C, Innes, J A, Maher, T M, Moran, C, Meng, C, Paul-Smith, M C, Pringle, I A, Pytel, K M, Rodriguez-Martinez, A, Schmidt, A C, Stevenson, B, Sumner-Jones, S G, Toshner, R, Tsugumine, S, Wasowicz, M W & Zhu, J 2017, ' Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis ', Thorax, vol. 72, no. 2, pp. 137-147 . https://doi.org/10.1136/thoraxjnl-2016-208406
Thorax

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemaggluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f6bf734ca182ac101485c3ece68626a2
https://ora.ox.ac.uk/objects/uuid:06e16f3b-e8eb-4ccb-b37f-5e85a5a75530

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A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Alton, Eric Wfw, Armstrong, David K, Ashby, Deborah, Bayfield, Katie J, Bilton, Diana, Bloomfield, Emily V, Boyd, A Christopher, Brand, June, Buchan, Ruaridh, Calcedo, Roberto, Carvelli, Paula, Chan, Mario, Cheng, Seng H, Collie, David S, Cunningham, Steve, Davidson, Heather E, Davies, Gwyneth, Davies, Jane C, Davies, Lee A, Dewar, Maria H, Doherty, Ann, Donovan, Jackie, Dwyer, Natalie S, Elgmati, Hala I, Featherstone, Rosanna F, Gavino, Jemyr, Gea-sorli, Sabrina, Geddes, Duncan M, Gibson, James Sr, Gill, Deborah R, Greening, Andrew P, Griesenbach, Uta, Hansell, David M, Harman, Katharine, Higgins, Tracy E, Hodges, Samantha L, Hyde, Stephen C, Hyndman, Laura, Innes, J Alastair, Jacob, Joseph, Jones, Nancy, Keogh, Brian F, Limberis, Maria P, Lloyd-evans, Paul, Maclean, Alan W, Manvell, Michelle C, Mccormick, Dominique, Mcgovern, Michael, Mclachlan, Gerry, Meng, Cuixiang, Montero, M Angeles, Milligan, Hazel, Moyce, Laura J, Murray, Gordon D, Nicholson, Andrew G, Osadolor, Tina, Parra-leiton, Javier, Porteous, David J, Pringle, Ian A, Punch, Emma K, Pytel, Kamila M, Quittner, Alexandra L, Rivellini, Gina, Saunders, Clare J, Scheule, Ronald K, Sheard, Sarah, Simmonds, Nicholas J, Smith, Keith, Smith, Stephen N, Soussi, Najwa, Soussi, Samia, Spearing, Emma J, Stevenson, Barbara J, Sumner-jones, Stephanie G, Turkkila, Minna, Ureta, Rosa P, Waller, Michael D, Wasowicz, Marguerite Y, Wilson, James M, Wolstenholme-hogg, Paul

Publikováno v: Alton, E W, Armstrong, D K, Ashby, D, Bayfield, K J, Bilton, D, Bloomfield, E V, Boyd, A C, Brand, J, Buchan, R, Calcedo, R, Carvelli, P, Chan, M, Cheng, S H, Collie, D S, Cunningham, S, Davidson, H E, Davies, G, Davies, J C, Davies, L A, Dewar, M H, Doherty, A, Donovan, J, Dwyer, N S, Elgmati, H I, Featherstone, R F, Gavino, J, Gea-sorli, S, Geddes, D M, Gibson, J S, Gill, D R, Greening, A P, Griesenbach, U, Hansell, D M, Harman, K, Higgins, T E, Hodges, S L, Hyde, S C, Hyndman, L, Innes, J A, Jacob, J, Jones, N, Keogh, B F, Limberis, M P, Lloyd-evans, P, Maclean, A W, Manvell, M C, Mccormick, D, Mcgovern, M, Mclachlan, G, Meng, C, Montero, M A, Milligan, H, Moyce, L J, Murray, G D, Nicholson, A G, Osadolor, T, Parra-leiton, J, Porteous, D J, Pringle, I A, Punch, E K, Pytel, K M, Quittner, A L, Rivellini, G, Saunders, C J, Scheule, R K, Sheard, S, Simmonds, N J, Smith, K, Smith, S N, Soussi, N, Soussi, S, Spearing, E J, Stevenson, B J, Sumner-jones, S G, Turkkila, M, Ureta, R P, Waller, M D, Wasowicz, M Y, Wilson, J M & Wolstenholme-hogg, P 2016, A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis . Efficacy and Mechanism Evaluation, no. 5, vol. 3, vol. 3 . https://doi.org/10.3310/eme03050

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::652d7f6547305ca5fd120989d6732d40
https://hdl.handle.net/20.500.11820/6cbd29f1-9d74-4a71-a11a-6d87edad87e6

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