Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire.

Autor: Altman, Pilar X.^1,2,3 (AUTHOR), Ozorowski, Gabriel^2,3,4 (AUTHOR), Stanfield, Robyn L.⁴ (AUTHOR), Haakenson, Jeremy^5,6 (AUTHOR), Appel, Michael^3,7 (AUTHOR), Parren, Mara¹ (AUTHOR), Lee, Wen-Hsin⁴ (AUTHOR), Sang, Huldah⁸ (AUTHOR), Woehl, Jordan^3,7 (AUTHOR), Saye-Francisco, Karen¹ (AUTHOR), Sewall, Leigh M.⁴ (AUTHOR), Joyce, Collin^1,2,3 (AUTHOR), Song, Ge^1,2,3 (AUTHOR), Porter, Katelyn¹ (AUTHOR), Landais, Elise^3,7 (AUTHOR), Andrabi, Raiees^1,2,3,9 (AUTHOR), Wilson, Ian A.^2,3,4,10 (AUTHOR), Ward, Andrew B.^2,3,4 (AUTHOR), Mwangi, Waithaka⁸ (AUTHOR), Smider, Vaughn V.^5,6 (AUTHOR)

Publikováno v: PLoS Pathogens. 9/9/2024, Vol. 20 Issue 9, p1-32. 32p.

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Structural and functional analysis of cooperativity in a potent human antibody cocktail against Ebola virus

Autor: Gilchuk, Pavlo, Murin, Charles D., Milligan, Jacob C., Cross, Robert W., Mire, Chad E., Ilinykh, Philipp A., Kai Huang, Kuzmina, Natalia, Altman, Pilar X., Hui, Sean, Gunn, Bronwyn M., Bryan, Aubrey L., Davidson, Edgar, Doranz, Benjamin J., Turner, Hannah L., Alkutkar, Tanwee, Flinko, Robin, Orlandi, Chiara, Carnahan, Robert, Nargi, Rachel, Bombardi, Robin G., Vodzak, Megan E., Li, Sheng, Okoli, Adaora, Ibeawuchi, Morris, Ohiaeri, Benjamin, Lewis, George K., Alter, Galit, Bukreyev, Alexander, Saphire, Erica Ollmann, Geisbert, Thomas W., Ward, Andrew B., Crowe, James E.

Publikováno v: Web of Science

Structural principles underlying the composition of protective antiviral monoclonal antibody (mAb) cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic mAb cocktail against Ebola virus (EBOV). Systematic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec598282ccfcf1d4405536eaaa033348
https://publons.com/wos-op/publon/36353498/

Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire.

Autor: Altman PX; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Ozorowski G; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Stanfield RL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Haakenson J; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.; Applied Biomedical Science Institute, San Diego, CA, USA., Appel M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA., Parren M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Sang H; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medical, Kansas State University, Manhattan, Kansas, USA., Woehl J; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA., Saye-Francisco K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Joyce C; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Song G; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Porter K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Landais E; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA., Andrabi R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wilson IA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Mwangi W; Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medical, Kansas State University, Manhattan, Kansas, USA., Smider VV; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.; Applied Biomedical Science Institute, San Diego, CA, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, USA., Sok D; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; International AIDS Vaccine Initiative, New York, NY, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 14. Date of Electronic Publication: 2024 Feb 14.